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+% paths.patient_dir
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+% paths.Goal_dir (previously called DP_dir)
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+% paths.patient
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+% paths.goalsName
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+
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+% colorwash(Geometry.data, D_full, [500, 1500], [0,70])
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+% orthoslice(D_full, [0,70])
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+
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+function [D_full, w_fin, Geometry, optGoal] = NLP_optimizer_v2(varargin)
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+% This function performs the beamlet optimization
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+% [D_full, w_fin, Geometry, optGoal] = NLP_beamlet_optimizer;
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+%
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+% Inputs:
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+% () OR
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+% (Pat_path, path2goal) OR
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+% (Pat_path, path2goal, beamlet_weights)
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+% Pat_path, path2goal = strings to patient folder and optimal goals
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+% beamlet_weights = initial beamlet weights
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+%
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+% Outputs:
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+% full dose image dose: [D_full, w_fin, Geometry, optGoal]
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+%
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+% Made by Peter Ferjancic 1. May 2018
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+% Last updated: 1. April 2019
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+
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+if nargin<2
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+ load('WiscPlan_preferences.mat')
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+ [Pat_path] = uigetdir([WiscPlan_preferences.patientDataPath ], 'Select Patient folder');
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+ [Goal_file,Goal_path,indx] = uigetfile([Pat_path '\matlab_files\*.mat'], 'Select OptGoal file');
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+
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+ path2geometry = [Pat_path, '\matlab_files\Geometry.mat'];
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+ path2goal = [Goal_path, Goal_file];
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+else
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+ Pat_path = varargin{1};
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+ path2geometry = [Pat_path, '\matlab_files\Geometry.mat'];
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+ path2goal = varargin{2};
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+ [Goal_path,Goal_file,ext] = fileparts(path2goal);
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+end
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+
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+str = inputdlg({'N of iterations for initial calc', 'N of iterations for full calc', ...
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+ 'Use pre-existing NLP_result to initiate? (y/n)'}, 'input', [1,35], {'100000', '500000', 'n'});
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+N_fcallback1 = str2double(str{1}); % 100000 is a good guesstimate
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+N_fcallback2 = str2double(str{2}); % 500000 is a good guesstimate
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+pre_beamWeights = str{3};
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+
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+switch pre_beamWeights
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+ case 'y'
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+ [NLP_file,NLP_path,indx] = uigetfile([Pat_path '\matlab_files\*.mat'], 'Select NLP_result file');
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+ load([NLP_path, NLP_file])
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+ w_beamlets = NLP_result.weights;
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+
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+ load([Pat_path, '\all_beams.mat'])
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+ if numel(all_beams) ~= numel(w_beamlets)
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+ error('Provided weight number does not match beamlet number!')
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+ end
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+ case 'n'
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+ disp('Initial beam weights will be calculated.')
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+end
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+
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+%% PROGRAM STARTS HERE
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+% - no tocar lo que hay debajo -
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+fprintf('starting NLP optimization process... \n')
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+
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+% % -- LOAD GEOMETRY, GOALS, BEAMLETS --
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+load(path2geometry)
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+load(path2goal)
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+[beamlets, numBeamlet] = get_beamlets(Geometry, Pat_path);
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+% [beamlets, beamlets_joined, numBeamlet, numBeam, beam_i_list] = get_beam_lets(Geometry, Pat_path);
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+
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+
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+%% -- OPTIMIZATION TARGETS --
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+% -- make the optimization optGoal structure --
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+for i_goal = 1:size(OptGoals.goals,1)
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+ if isfield(OptGoals.data{i_goal}, 'SupVox_num')
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+ SupVox_num = OptGoals.data{i_goal}.SupVox_num;
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+ else
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+ answer = inputdlg(['# of supervoxels for "' OptGoals.data{i_goal}.name '" with ' num2str(numel(OptGoals.data{i_goal}.ROI_idx)) ' vox: ("0" to skip)'])
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+ SupVox_num = str2double(answer{1})
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+ end
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+ switch SupVox_num
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+ case 0
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+ % if not supervoxel, just select provided ROI_idx
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+ optGoal{i_goal} = OptGoals.data{i_goal};
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+ optGoal{i_goal}.beamlets_pruned = sparse(beamlets(optGoal{i_goal}.ROI_idx, :));
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+
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+ otherwise
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+ % -- if supervoxel, merge given columns
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+ % - make supervoxel map
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+ mask = zeros(OptGoals.data{i_goal}.imgDim);
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+ mask(OptGoals.data{i_goal}.ROI_idx) = 1;
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+ superMask = superpix_group(mask, SupVox_num);
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+ superVoxList = unique(superMask);
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+ superVoxList = superVoxList(superVoxList>0);
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+
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+ optGoal{i_goal} = OptGoals.data{i_goal};
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+ optGoal{i_goal}.ROI_idx_old = optGoal{i_goal}.ROI_idx; % copy old index data
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+ optGoal{i_goal}.ROI_idx = zeros(numel(superVoxList), 1);
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+ optGoal{i_goal}.opt_weight = optGoal{i_goal}.opt_weight * numel(optGoal{i_goal}.ROI_idx_old)/numel(optGoal{i_goal}.ROI_idx);
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+
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+ h_w1 = waitbar(0, 'merging superboxels');
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+ for i_supVox = 1:numel(superVoxList)
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+ waitbar(i_supVox/numel(superVoxList), h_w1)
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+ supVox_idx = superVoxList(i_supVox);
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+ idxList = find(superMask == supVox_idx);
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+ optGoal{i_goal}.beamlets_pruned(i_supVox,:) = sparse(mean(beamlets(idxList, :),1));
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+ % -- make new indeces
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+ optGoal{i_goal}.ROI_idx(i_supVox) = idxList(1);
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+ end
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+ close(h_w1)
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+ end
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+end
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+
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+
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+
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+% -- make them robust --
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+RO_params=0;
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+optGoal = make_robust_optGoal(optGoal, RO_params, beamlets);
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+
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+% -- CALLBACK OPTIMIZATION FUNCTION --
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+fun1 = @(x) get_penalty(x, optGoal_beam);
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+fun2 = @(x) get_penalty(x, optGoal);
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+
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+% -- OPTIMIZATION PARAMETERS --
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+% define optimization parameters
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+A = [];
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+b = [];
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+Aeq = [];
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+beq = [];
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+lb = zeros(1, numBeamlet);
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+% lb_beam = zeros(1, numBeam);
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+ub = [];
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+nonlcon = [];
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+
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+% define opt limits, and make it fmincon progress
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+options = optimoptions('fmincon');
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+options.MaxFunctionEvaluations = N_fcallback1;
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+options.Display = 'iter';
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+options.PlotFcn = 'optimplotfval';
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+% options.UseParallel = true;
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+options.UseParallel = false;
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+% options.OptimalityTolerance = 1e-9;
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+
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+%% -- INITIALIZE BEAMLET WEIGHTS --
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+switch pre_beamWeights
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+ case 'y'
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+ % should have been assigned previously.
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+ disp('Provided beamlet weights used for initial comparison')
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+ case 'n'
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+ % if initial beamlet weights are not provided, get quick estimate
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+% fprintf('\n running initial optimizer:')
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+ % initialize beamlet weights, OR
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+ w0 = ones(numBeamlet,1);
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+ w0 = mean(optGoal{1}.D_final(optGoal{1}.ROI_idx) ./ (optGoal{1}.beamlets_pruned*w0+0.1)) * w0;
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+ w_beamlets = double(w0);
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+
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+ % -- GET BEAM WEIGHTS --
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+% tic
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+% w_beam = fmincon(fun1,w0_beams,A,b,Aeq,beq,lb,ub,nonlcon,options);
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+% fprintf(' done!:')
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+% t=toc;
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+% disp(['Optimization time for beams = ',num2str(t)]);
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+%
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+% w_beamlets = ones(numBeamlet,1);
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+% numBeam=numel(unique(beam_i_list));
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+% for beam_i = 1:numBeam % assign weights to beamlets
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+% % beamlets from same beam get same initial weights
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+% w_beamlets(beam_i_list == beam_i) = w_beam(beam_i);
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+% end
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+end
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+
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+%% FULL OPTIMIZATION
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+
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+% -- GET FULL BEAMLET WEIGHTS --
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+options.MaxFunctionEvaluations = N_fcallback2;
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+tic
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+fprintf('\n running full optimizer:')
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+w_fin = fmincon(fun2,w_beamlets,A,b,Aeq,beq,lb,ub,nonlcon,options);
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+fprintf(' done!:')
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+t=toc;
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+disp(['Optimization time for beamlets = ',num2str(t)]);
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+
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+
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+%% evaluate the results
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+D_full = reshape(beamlets * w_fin, size(Geometry.data));
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+
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+%% save outputs
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+NLP_result.dose = D_full;
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+NLP_result.weights = w_fin;
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+save([Pat_path, '\matlab_files\NLP_result_' Goal_file '.mat'], 'NLP_result');
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+
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+
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+plot_DVH(Geometry, D_full)
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+colorwash(Geometry.data, D_full, [500, 1500], [0, 36]);
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+
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+
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+end
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+
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+%% support functions
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+% ---- PENALTY FUNCTION ----
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+function penalty = get_penalty(x, optGoal)
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+ % this function gets called by the optimizer. It checks the penalty for
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+ % all the robust implementation and returns the worst result.
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+
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+ NumScenarios = optGoal{1}.NbrRandScenarios * optGoal{1}.NbrSystSetUpScenarios * optGoal{1}.NbrRangeScenarios;
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+ fobj = zeros(NumScenarios,1);
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+ sc_i = 1;
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+
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+ for nrs_i = 1:optGoal{1}.NbrRandScenarios
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+ for sss_i = 1 :optGoal{1}.NbrSystSetUpScenarios % syst. setup scenarios = sss
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+ for rgs_i = 1:optGoal{1}.NbrRangeScenarios % range scenario = rs
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+ fobj(sc_i)=eval_f(x, optGoal, nrs_i, sss_i, rgs_i);
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+ sc_i = sc_i + 1;
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+ end
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+ end
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+ end
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+ % take the worst case penalty of evaluated scenarios
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+ penalty=max(fobj);
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+end
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+% ------ supp: penalty for single scenario ------
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+function penalty = eval_f(x, optGoal, nrs_i, sss_i, rgs_i)
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+ penalty = 0;
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+ % for each condition
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+ for goal_i = 1:numel(optGoal)
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+ switch optGoal{goal_i}.function
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+ % min, max, min_sq, max_sq, LeastSquare, min_perc_Volume, max_perc_Volume
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+ case 'min'
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+ % penalize if achieved dose is lower than target dose
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+ d_penalty = 1.0e0 * sum(max(0, ...
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+ (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.target) -...
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+ (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.beamlets_pruned * x)));
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+ case 'max'
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+ % penalize if achieved dose is higher than target dose
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+ d_penalty = 1.0e0 * sum(max(0, ...
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+ (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.beamlets_pruned * x)-...
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+ (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.target)));
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+ case 'min_sq'
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+ % penalize if achieved dose is lower than target dose
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+ temp1=min(0, (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.beamlets_pruned * x)-...
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+ (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.target));
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+ d_penalty = 1.0e0 * sum(temp1.*temp1);
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+ case 'max_sq'
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+ % penalize if achieved dose is higher than target dose
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+ temp1=max(0, (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.beamlets_pruned * x)-...
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+ (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.target));
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+ d_penalty = 1.0e0 * sum(temp1.*temp1);
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+ case 'min_exp'
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+ % penalize if achieved dose is lower than target dose
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+ temp1=-min(0, (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.beamlets_pruned * x)-...
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+ (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.target));
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+ d_penalty = 1.0e0 * sum(exp(temp1));
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+ case 'max_exp'
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+ % penalize if achieved dose is higher than target dose
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+ temp1=max(0, (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.beamlets_pruned * x)-...
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+ (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.target));
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+ d_penalty = 1.0e0 * sum(exp(temp1));
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+ case 'LeastSquare'
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+ % penalize with sum of squares any deviation from target
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+ % dose
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+ temp1 = (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.beamlets_pruned * x) - ...
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+ optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.target;
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+ d_penalty = 1.0e0* sum(temp1.^2);
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+ case 'min_perc_Volume'
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+ % penalize by amount of volume under threshold
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+ perc_vox = numel(find((optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.target) -...
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+ (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.beamlets_pruned * x) > 0)) ...
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+ / numel(optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.target);
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+ d_penalty = 3.0e4 * min(perc_vox-0.05, 0)
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+
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+ case 'max_perc_Volume'
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+ % penalize by amount of volume under threshold
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+ perc_vox = numel(find((optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.target) -...
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+ (optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.beamlets_pruned * x) < 0)) ...
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+ / numel(optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.target);
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+ d_penalty = 3.0e4 * min(perc_vox-0.05, 0)
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+
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+ end
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+ penalty = penalty + d_penalty * optGoal{goal_i}.opt_weight;
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+ end
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+end
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+
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+% ---- MAKE ROI ROBUST ----
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+function optGoal = make_robust_optGoal(optGoal, RO_params, beamlets);
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+ % take regular optimal goal and translate it into several robust cases
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+
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+ % RO_params - should have the information below
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+ % nrs - random scenarios
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+ % sss - system setup scenarios
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+ % rgs - random range scenarios
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+
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+ % X - X>0 moves image right
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+ % Y - Y>0 moves image down
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+ % Z - in/out.
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+
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+ shift_mag = 1; % vox of shift
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+ nrs_scene_list={[0,0,0]};
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+
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+
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+ % ----====#### CHANGE ROBUSTNESS HERE ####====----
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+
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+% sss_scene_list={[0,0,0]};
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+ sss_scene_list={[0,0,0], [-shift_mag,0,0], [shift_mag,0,0], [0,-shift_mag,0], [0,shift_mag,0], [0,0,-1], [0,0,1]};
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+% sss_scene_list={[0,0,0], [-shift_mag,0,0], [shift_mag,0,0], [0,-shift_mag,0], [0,shift_mag,0],...
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+% [-shift_mag*2,0,0], [shift_mag*2,0,0], [0,-shift_mag*2,0], [0,shift_mag*2,0]};
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+
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+ % ----====#### CHANGE ROBUSTNESS HERE ####====----
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+
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+ rgs_scene_list={[0,0,0]};
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+
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+% [targetIn, meta] = nrrdread('C:\010-work\003_localGit\WiscPlan_v2\data\archive\CDP_data\CDP5_DP_target.nrrd');
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+% [targetIn, meta] = nrrdread('C:\010-work\003_localGit\WiscPlan_v2\data\PD_HD_dicomPhantom\Tomo_DP_target.nrrd');
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+% [targetIn, meta] = nrrdread('C:\010-work\003_localGit\WiscPlan_v2\data\archive\CDP_data\CDP5_DP_target.nrrd');
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+
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+ for i = 1:numel(optGoal)
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+ optGoal{i}.NbrRandScenarios =numel(nrs_scene_list);
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+ optGoal{i}.NbrSystSetUpScenarios=numel(sss_scene_list);
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+ optGoal{i}.NbrRangeScenarios =numel(rgs_scene_list);
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+ end
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+
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+
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+ for goal_i = 1:numel(optGoal)
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+ % get target
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+ idx=optGoal{goal_i}.ROI_idx;
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+ targetImg1=zeros(optGoal{goal_i}.imgDim);
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+ targetImg1(idx)=1;
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+ % get beamlets
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+
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+ for nrs_i = 1:optGoal{goal_i}.NbrRandScenarios % num. of random scenarios
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+ % modify target and beamlets
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+ targetImg2=targetImg1;
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+ % beamlets stay the same
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+
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+ for sss_i = 1 :optGoal{goal_i}.NbrSystSetUpScenarios % syst. setup scenarios = sss
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+ % modify target and beamlets
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+ [targetImg3 idxValid]=get_RO_sss(targetImg2, sss_scene_list{sss_i});
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+ % beamlets stay the same
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+
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+ for rgs_i = 1:optGoal{goal_i}.NbrRangeScenarios % range scenario = rgs
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+ % modify target and beamlets
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+ targetImg4=targetImg3;
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+ % beamlets stay the same
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+
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+ %% make new target and beamlets
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+ ROI_idx=[];
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+ ROI_idx=find(targetImg4>0);
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+
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+ target = optGoal{goal_i}.D_final(idxValid);
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+
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+ beamlets_pruned = beamlets(ROI_idx, :);
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+
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+ % save to optGoal output
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+ optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.ROI_idx = ROI_idx;
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+ optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.beamlets_pruned = beamlets_pruned;
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+ optGoal{goal_i}.nrs{nrs_i}.sss{sss_i}.rgs{rgs_i}.target = target;
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+ end
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+ end
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+ end
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+ end
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+end
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+% ------ supp: RO case SSS ------
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+function [targetImg3 ia]=get_RO_sss(targetImg2, sss_scene_shift);
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+ % translate the target image
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+
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+ targetImg3 = imtranslate(targetImg2,sss_scene_shift);
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+
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+ % now we need to figure out if any target voxels fell out during the
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+ % shift
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+ imgValid = imtranslate(targetImg3,-sss_scene_shift);
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+ imgInvalid = (targetImg2-imgValid);
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+
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+ idx_1 = find(targetImg2);
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+ idx_2 = find(imgInvalid);
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+
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+ [idxValid,ia] = setdiff(idx_1,idx_2);
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+
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+ [C,ia, ib] = intersect(idx_1,idxValid);
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+
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+end
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+
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+
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+
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+
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