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@@ -1,10 +1,12 @@
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{
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+ "timeUnit":"min",
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"compartments":[
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- "redBloodCells","arterial","venous","kidney","urine",
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+ "redBloodCells","plasma","venous","kidney","urine",
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"richlyPerfused","fat","slowlyPerfused","hair",
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"brainBlood","brain","placenta",
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"liver","gut","intestine","feces","inorganicMercury"],
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"commentParameters":"every parameter must have a value, name is optional and used in SE computation",
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+ "volumeComment":"in a compartment w/o volume, value is mass",
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"volumes":{
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"plasma":"plasmaVolume",
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"venous":"plasmaVolume",
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@@ -15,7 +17,12 @@
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"brainBlood":"brainBloodVolume",
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"placenta":"placentaVolume",
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"gut":"gutVolume",
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- "intestine":"intestineVolume"},
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+ "intestine":"intestineVolume",
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+ "redBloodCells":"redBloodCellsVolume",
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+ "hair":"hairVolume",
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+ "brain":"brainVolume",
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+ "liver":"liverVolume"
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+ },
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"flows":{
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"(plasma,venous):kidney":"kidneyFlow",
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"(plasma,venous):richlyPerfused":"richlyPerfusedFlow",
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@@ -30,8 +37,7 @@
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"commentSources":"constants in concentration units per s",
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"commentHeavyside":"value is mass of exogene/volume of container/duration",
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"sources":{
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- "arterial":{"name":"exponential","k":-0.005,"constant":0},
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- "venous":{"name":"Heavyside","limit":3,"value":1.22e4}},
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+ "intestine":{"name":"constant","value":0.0486,"unit":"ug/min"}},
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"commentBindings":"split to flow and diffusion dominated",
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"bindings": {
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"flowComments":"group common sources or targets with brackets",
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@@ -42,8 +48,10 @@
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"venous->plasma"],
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"diffusion":{
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"plasma->redBloodCells":"kRBC",
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+ "redBloodCells->plasma":"kRBC",
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"kidney->urine":"kU",
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"slowlyPerfused->hair":"kH",
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+ "hair->slowlyPerfused":"kH",
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"brainBlood->brain":"kBR",
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"liver->intestine":"kB",
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"liver->inorganicMercury":"kI",
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@@ -62,8 +70,8 @@
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"liver":"liverPC",
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"gut":"gutPC",
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"brainBlood->brain":"brainPC",
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- "slowlyPerfused->hair":"hairPC",
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- "plasma->redBloodCells":"rbcPC"},
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+ "hair->slowlyPerfused":"hairPC",
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+ "redBloodCells->plasma":"rbcPC"},
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"parameters":{
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"kidneyPC":{"value":4.0},
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"richlyPerfusedPC":{"value":1},
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@@ -77,6 +85,7 @@
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"gutPC":{"value":1},
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"rbcPC":{"value":12},
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"flowNotes":"assuming 70kg individual, fetus at 0.1kg",
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+ "plasmaFlow":{"value":8.067,"unit":"l/min"},
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"kidneyFlow":{"value":1.412,"unit":"l/min"},
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"richlyPerfusedFlow":{"value":1.484,"unit":"l/min"},
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"fatFlow":{"value":0.419,"unit":"l/min"},
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@@ -99,14 +108,14 @@
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"liverVolume":{"value":1.82,"unit":"kg"},
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"gutVolume":{"value":1.19,"unit":"kg"},
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"intestineVolume":{"value":0.98,"unit":"kg"},
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- "kRBC":{"value":0.025,"unit":"l/min"},
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+ "kRBC":{"value":0.60,"unit":"l/min"},
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"kU":{"value":0,"unit":"l/min"},
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- "kH":{"value":1.167e-7,"unit":"l/min"},
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- "kBR":{"value":1.67e-4,"unit":"l/min"},
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- "kI":{"value":1.67e-7,"unit":"l/min"},
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- "kB":{"value":1.67e-6,"unit":"l/min"},
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- "kD":{"value":1.67e-6,"unit":"l/min"},
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- "kF":{"value":3.33e-6,"unit":"l/min"},
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+ "kH":{"value":2.823e-6,"unit":"l/min"},
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+ "kBR":{"value":4.033e-3,"unit":"l/min"},
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+ "kI":{"value":4.033e-6,"unit":"l/min"},
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+ "kB":{"value":4.033e-5,"unit":"l/min"},
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+ "kD":{"value":4.033e-5,"unit":"l/min"},
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+ "kF":{"value":8.066e-5,"unit":"l/min"},
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"kF1":{"value":0,"unit":"l/min"},
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- "kR":{"value":8.33e-5,"unit":"l/min"}
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+ "kR":{"value":2.016e-3,"unit":"l/min"}}
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}
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