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@@ -0,0 +1,76 @@
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+{
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+ "compartments":["adipose","brain","heart","kidney","liver",
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+ "splanchnic","stomach","muscle","skin","testes","remainder","lung",
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+ "excrement","arterial","venous","source"],
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+ "volumes":{
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+ "unit":"g",
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+ "adipose":10,
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+ "brain":1.2,
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+ "heart":1,
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+ "kidney":2,
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+ "liver":11,
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+ "lung":1.2,
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+ "muscle":125,
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+ "skin":43.8,
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+ "splanchnic":15,
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+ "stomach":1.1,
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+ "testes":2.5,
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+ "remainder":15.8,
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+ "venous":13.6,
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+ "arterial":6.8},
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+ "flowNotes":"liver:arterial is sum of liver,splanchnic and stomach",
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+ "flowNotes1":"liver:arterial=3.55+20.25+1.9",
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+ "flows":{
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+ "unit":"ml/min",
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+ "(arterial,venous):adipose":2.55,
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+ "(arterial,venous):brain":0.78,
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+ "(arterial,venous):heart":4.2,
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+ "(arterial,venous):kidney":16.61,
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+ "arterial:liver":3.55,
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+ "liver:venous":25.7,
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+ "(arterial,venous):lung":80,
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+ "(arterial,venous):muscle":16.25,
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+ "(arterial,venous):skin":7.1,
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+ "(arterial,liver):splanchnic":20.25,
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+ "(arterial,liver):stomach":1.9,
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+ "(arterial,venous):testes":1.9,
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+ "(arterial,venous):remainder":4.91,
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+ "arterial":80,
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+ "venous":80},
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+ "commentSources":"constants in concentration units per s",
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+ "sources":{
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+ "arterial":{"name":"exponential","k":-0.005,"constant":0},
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+ "venous":{"name":"Heavyside","limit":30,"value":1.22e3}},
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+ "commentBindings":"split to flow and diffusion dominated",
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+ "bindings": {
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+ "flowComments":"group common sources or targets with braces",
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+ "flow":[
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+ "(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder)->venous",
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+ "(splanchnic,stomach)->liver",
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+ "arterial->(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder,splanchnic,stomach)",
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+ "venous->lung",
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+ "lung->arterial"],
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+ "diffusionComments":"source->target strength per s",
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+ "liverToExcrementNotes":"CL=422ml/min,PC=9.1,f=0.15,V=11g->k=0.105/s",
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+ "sourceToArterialNotes":"ka=0.001/s in paper",
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+ "comment:source->venous":0.005,
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+ "diffusion":{
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+ "liver->excrement":0.0105}},
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+ "pcComments":"always related to outflow of organs",
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+ "partitionCoefficients":{
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+ "adipose":0.04,
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+ "brain":0.27,
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+ "heart":0.28,
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+ "kidney":0.72,
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+ "liver":0.39,
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+ "lung":0.3,
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+ "muscle":0.29,
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+ "remainder":0.18,
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+ "skin":0.18,
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+ "splanchnic":0.31,
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+ "stomach":0.18,
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+ "testes":0.18},
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+ "sensitivityCalculation":{
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+ "parameters":["partitionCoefficients"]
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+ }
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+}
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