Removing files not required

models/cCotinine.json

@@ -1,109 +0,0 @@
-{
-   "compartments":["adipose","brain","heart","kidney","liver",
-   "splanchnic","stomach","muscle","skin","testes","remainder","lung",
-   "excrement","arterial","venous","source"],
-   "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
-   "volumes":{
-      "adipose":"adiposeVolume",
-      "brain":"brainVolume",
-      "heart":"heartVolume",
-      "kidney":"kidneyVolume",
-      "liver":"liverVolume",
-      "lung":"lungVolume",
-      "muscle":"muscleVolume",
-      "skin":"skinVolume",
-      "splanchnic":"splanchnicVolume",
-      "stomach":"stomachVolume",
-      "testes":"testesVolume",
-      "remainder":"remainderVolume",
-      "venous":"venousVolume",
-      "arterial":"arterialVolume"},
-   "flows":{
-      "(arterial,venous):adipose":"adiposeFlow",
-      "(arterial,venous):brain":"brainFlow",
-      "(arterial,venous):heart":"heartFlow",
-      "(arterial,venous):kidney":"kidneyFlow",
-      "arterial:liver":"liverInFlow",
-      "liver:venous":"liverOutFlow",
-      "(arterial,venous):lung":"totalFlow",
-      "(arterial,venous):muscle":"muscleFlow",
-      "(arterial,venous):skin":"skinFlow",
-      "(arterial,liver):splanchnic":"splanchnicFlow",
-      "(arterial,liver):stomach":"stomachFlow",
-      "(arterial,venous):testes":"testesFlow",
-      "(arterial,venous):remainder":"remainderFlow"},
-   "commentSources":"constants in concentration units per s",
-   "commentHeavyside":"value is mass of exogene/volume of container/duration",
-   "sources":{
-      "arterial":{"name":"exponential","k":-0.005,"constant":0},
-      "venous":{"name":"Heavyside","limit":3,"value":1.22e4}},
-   "commentBindings":"split to flow and diffusion dominated",
-   "bindings": {
-      "flowComments":"group common sources or targets with brackets",
-      "flow":[
-         "(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder)->venous",
-         "(splanchnic,stomach)->liver",
-         "arterial->(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder,splanchnic,stomach)",
-         "venous->lung",
-         "lung->arterial"],
-      "diffusion":{
-         "liver->excrement":"k1"}},
-    "pcComments":"always related to outflow of organs", 
-    "partitionCoefficients":{
-       "adipose":"adiposePC",
-       "brain":"brainPC",
-       "heart":"heartPC",
-       "kidney":"kidneyPC",
-       "liver":"liverPC",
-       "lung":"lungPC",
-       "muscle":"musclePC",
-       "remainder":"remainderPC",
-       "skin":"remainderPC",
-       "splanchnic":"splanchnicPC",
-       "stomach":"stomachPC",
-       "testes":"testesPC"},
-     "parameters":{
-        "adiposePC":{"value":0.04,"dist":"lognormal","cv":0.3},
-	     "brainPC":{"value":0.27,"dist":"lognormal","cv":0.3},
-	     "heartPC":{"value":0.28},
-        "kidneyPC":{"value":0.72},
-	     "liverPC":{"value":0.39},
-	     "lungPC":{"value":0.3},
-	     "musclePC":{"value":0.29},
-        "remainderPC":{"value":0.18},
-	     "splanchnicPC":{"value":0.31},
-	     "stomachPC":{"value":0.18},
-	     "testesPC":{"value":0.18},
-        "flowNotes":"liverOutFlow is sum of liver,splanchnic and stomach",
-        "flowNotes1":"liverOutFlow=3.55+20.25+1.9",
-        "adiposeFlow":{"value":2.55,"unit":"ml/min"},
-        "brainFlow":{"value":0.78,"unit":"ml/min"},
-        "heartFlow":{"value":4.2,"unit":"ml/min"},
-        "kidneyFlow":{"value":16.61,"unit":"ml/min"},
-        "liverInFlow":{"value":3.55,"unit":"ml/min"},
-        "liverOutFlow":{"value":25.7,"unit":"ml/min"},
-        "totalFlow":{"value":80,"unit":"ml/min"},
-        "muscleFlow":{"value":16.25,"unit":"ml/min"},
-        "skinFlow":{"value":7.1,"unit":"ml/min"},
-        "splanchnicFlow":{"value":20.25,"unit":"ml/min"},
-        "stomachFlow":{"value":1.9,"unit":"ml/min"},
-        "testesFlow":{"value":1.9,"unit":"ml/min"},
-        "remainderFlow":{"value":4.91,"unit":"ml/min"},
-        "adiposeVolume":{"value":10,"unit":"g"},
-        "brainVolume":{"value":1.2,"unit":"g"},
-        "heartVolume":{"value":1,"unit":"g"},
-        "kidneyVolume":{"value":2,"unit":"g"},
-        "liverVolume":{"value":11,"unit":"g"},
-        "lungVolume":{"value":1.2,"unit":"g"},
-        "muscleVolume":{"value":125,"unit":"g"},
-        "skinVolume":{"value":43.8,"unit":"g"},
-        "splanchnicVolume":{"value":15,"unit":"g"},
-        "stomachVolume":{"value":1.1,"unit":"g"},
-        "testesVolume":{"value":2.5,"unit":"g"},
-        "remainderVolume":{"value":15.8,"unit":"g"},
-        "venousVolume":{"value":13.6,"unit":"g"},
-        "arterialVolume":{"value":6.8,"unit":"g"},
-        "liverToExcrementNotes":"CL=0.13 ml/min,PC=0.39,f=0.97,V=11g->k1=0.00049/s",
-        "k1":{"value":0.0049,"unit":"1/s"}}
-
-}

models/cDiazepam.old.json

@@ -1,74 +0,0 @@
-{
-   "compartments":["adipose","brain","heart","kidney","liver",
-   "splanchnic","stomach","muscle","skin","testes","remainder","lung",
-   "excrement","arterial","venous","source"],
-   "volumes":{
-      "unit":"g",
-      "adipose":10,
-      "brain":1.2,
-      "heart":1,
-      "kidney":2,
-      "liver":11,
-      "lung":1.2,
-      "muscle":125,
-      "skin":43.8,
-      "splanchnic":15,
-      "stomach":1.1,
-      "testes":2.5,
-      "remainder":15.8,
-      "venous":13.6,
-      "arterial":6.8},
-   "flowNotes":"liver:arterial is sum of liver,splanchnic and stomach",
-   "flowNotes1":"liver:arterial=3.55+20.25+1.9",
-   "flows":{
-      "unit":"ml/min",
-      "(arterial,venous):adipose":2.55,
-      "(arterial,venous):brain":0.78,
-      "(arterial,venous):heart":4.2,
-      "(arterial,venous):kidney":16.61,
-      "arterial:liver":3.55,
-      "liver:venous":25.7,
-      "(arterial,venous):lung":80,
-      "(arterial,venous):muscle":16.25,
-      "(arterial,venous):skin":7.1,
-      "(arterial,liver):splanchnic":20.25,
-      "(arterial,liver):stomach":1.9,
-      "(arterial,venous):testes":1.9,
-      "(arterial,venous):remainder":4.91,
-      "arterial":80,
-      "venous":80},
-   "commentSources":"constants in concentration units per s",
-   "sources":{
-      "arterial":{"name":"exponential","k":-0.005,"constant":0},
-      "venous":{"name":"Heavyside","limit":300,"value":0.61e2}},
-   "commentBindings":"split to flow and diffusion dominated",
-   "bindings": {
-      "flowComments":"group common sources or targets with braces",
-      "flow":[
-         "(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder)->venous",
-            
-         "(splanchnic,stomach)->liver",
-         "arterial->(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder,splanchnic,stomach)",
-         "venous->lung",
-         "lung->arterial"],
-      "diffusionComments":"source->target strength per s",
-      "liverToExcrementNotes":"CL=422ml/min,PC=9.1,f=0.15,V=11g->k=0.0105/s",
-      "sourceToArterialNotes":"ka=0.001/s in paper",
-      "comment:source->venous":0.005,
-      "diffusion":{
-         "liver->excrement":0.0105}},
-    "pcComments":"always related to outflow of organs", 
-    "partitionCoefficients":{
-       "adipose":23.1,
-       "brain":2.2,
-       "heart":4.3,
-       "kidney":5.2,
-       "liver":9.1,
-       "lung":5.3,
-       "muscle":2.4,
-       "remainder":16.5,
-       "skin":3.2,
-       "splanchnic":4.3,
-       "stomach":4.5,
-       "testes":4.7}
-}

models/cModel.json

@@ -1,10 +0,0 @@
-{
-   "compartments":["blood","excrement"],
-   "commentSources":"in units per day",
-   "sources":{
-      "blood":1},
-   "commentBindings":"each gives source->target strength per day",
-   "bindings": {
-      "blood->excrement":0.1}
-   
-}

models/hgModel.json

@@ -1,18 +0,0 @@
-{
-   "compartments":["plasma","intestine","gut","liver","feces","kidney","urine"],
-   "commentSources":"in units per hr",
-   "sources":{
-      "intestine":1},
-   "commentBindings":"each gives source->target strength per hr",
-   "bindings": {
-      "intestine->feces":2e-4,
-      "intestine->gut":5e-3,
-      "gut->liver":0.181,
-      "plasma->liver":0.046,
-      "plasma->gut":0.181,
-      "plasma->kidney":0.175,
-      "liver->intestine":1e-4,
-      "liver->plasma":0.046,
-      "kidney->plasma":0.175,
-      "kidney->urine":1e-9}
-}

models/hgModel1.json

@@ -1,15 +0,0 @@
-{
-   "compartments":["plasma","intestine","gut","liver","feces"],
-   "commentSources":"in units per hr",
-   "sources":{
-      "intestine":1},
-   "commentBindings":"each gives source->target strength per hr",
-   "bindings": {
-      "intestine->feces":2e-4,
-      "intestine->gut":5e-3,
-      "gut->liver":0.181,
-      "plasma->liver":0.046,
-      "plasma->gut":0.181,
-      "liver->intestine":1e-4,
-      "liver->plasma":0.046}
-}

models/humanHG.json

@@ -1,72 +0,0 @@
-{
-   "timeUnit":"min",
-   "compartments":[
-      "redBloodCells","plasma","venous","kidney","urine",
-      "richlyPerfused","fat","slowlyPerfused","hair",
-      "brainBlood","brain",
-      "liver","gut","intestine","feces","inorganicMercury"],
-   "commentScaled":"add compartments that only have inputs so they can be scaled to total input",
-   "scaled":["hair","inorganicMercury","feces","urine"],
-   "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
-   "volumeComment":"in a compartment w/o volume, value is mass",
-   "volumes":{
-      "plasma":"plasmaVolume",
-      "venous":"venousVolume",
-      "kidney":"kidneyVolume",
-      "richlyPerfused":"richlyPerfusedVolume",
-      "fat":"fatVolume",
-      "slowlyPerfused":"slowlyPerfusedVolume",
-      "brainBlood":"brainBloodVolume",
-      "gut":"gutVolume",
-      "intestine":"intestineVolume",
-      "redBloodCells":"redBloodCellsVolume",
-      "brain":"brainVolume",
-      "liver":"liverVolume"
-      },
-   "flows":{
-      "(plasma,venous):kidney":"kidneyFlow",
-      "(plasma,venous):richlyPerfused":"richlyPerfusedFlow",
-      "(plasma,venous):fat":"fatFlow",
-      "(plasma,venous):slowlyPerfused":"slowlyPerfusedFlow",
-      "(plasma,venous):brainBlood":"brainBloodFlow",
-      "plasma:liver":"liverInFlow",
-      "liver:venous":"liverOutFlow",
-      "(plasma,liver):gut":"gutFlow",
-      "plasma:venous":"plasmaFlow"},
-   "commentSources":"constants in concentration units per s",
-   "commentHeavyside":"value is mass of exogene/volume of container/duration",
-   "inputs":{
-      "intestine":"oralIngestion"},
-   "commentBindings":"split to flow and diffusion dominated",
-   "bindings": {
-      "flowComments":"group common sources or targets with brackets",
-      "flow":[
-         "(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,liver)->venous",
-         "gut->liver",
-         "plasma->(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,liver,gut)",
-         "venous->plasma"],
-      "diffusion":{
-         "plasma->redBloodCells":"kRBC",
-         "redBloodCells->plasma":"kRBC",
-         "kidney->urine":"kU",
-         "slowlyPerfused->hair":"kH",
-         "brainBlood->brain":"kBR",
-         "brain->venous":"kBR",
-         "liver->intestine":"kB",
-         "liver->inorganicMercury":"kI",
-         "intestine->gut":"kR",
-         "intestine->inorganicMercury":"kD",
-         "intestine->feces":"kF",
-         "inorganicMercury->feces":"kIF"}},
-    "pcComments":"always related to outflow of organs", 
-    "partitionCoefficients":{
-       "kidney":"kidneyPC",
-       "richlyPerfused":"richlyPerfusedPC",
-       "fat":"fatPC",
-       "slowlyPerfused":"slowlyPerfusedPC",
-       "brainBlood":"brainBloodPC",
-       "liver":"liverPC",
-       "gut":"gutPC",
-       "brain->venous":"brainPC",
-       "redBloodCells->plasma":"rbcPC"}
-}

models/humanHG_RBC.json

@@ -1,72 +0,0 @@
-{
-   "timeUnit":"min",
-   "compartments":[
-      "redBloodCells","plasma","venous","kidney","urine",
-      "richlyPerfused","fat","slowlyPerfused","hair",
-      "brainBlood","brain",
-      "liver","gut","intestine","feces","inorganicMercury"],
-   "commentScaled":"add compartments that only have inputs so they can be scaled to total input",
-   "scaled":["hair","inorganicMercury","feces","urine"],
-   "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
-   "volumeComment":"in a compartment w/o volume, value is mass",
-   "volumes":{
-      "plasma":"plasmaVolume",
-      "venous":"venousVolume",
-      "kidney":"kidneyVolume",
-      "richlyPerfused":"richlyPerfusedVolume",
-      "fat":"fatVolume",
-      "slowlyPerfused":"slowlyPerfusedVolume",
-      "brainBlood":"brainBloodVolume",
-      "gut":"gutVolume",
-      "intestine":"intestineVolume",
-      "redBloodCells":"redBloodCellsVolume",
-      "brain":"brainVolume",
-      "liver":"liverVolume"
-      },
-   "flows":{
-      "(plasma,venous):kidney":"kidneyFlow",
-      "(plasma,venous):richlyPerfused":"richlyPerfusedFlow",
-      "(plasma,venous):fat":"fatFlow",
-      "(plasma,venous):slowlyPerfused":"slowlyPerfusedFlow",
-      "(plasma,venous):brainBlood":"brainBloodFlow",
-      "plasma:liver":"liverInFlow",
-      "liver:venous":"liverOutFlow",
-      "(plasma,liver):gut":"gutFlow",
-      "plasma:venous":"plasmaFlow"},
-   "commentSources":"constants in concentration units per s",
-   "commentHeavyside":"value is mass of exogene/volume of container/duration",
-   "inputs":{
-      "intestine":"oralIngestion"},
-   "commentBindings":"split to flow and diffusion dominated",
-   "bindings": {
-      "flowComments":"group common sources or targets with brackets",
-      "flow":[
-         "(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,liver)->venous",
-         "gut->liver",
-         "plasma->(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,liver,gut)",
-         "venous->plasma"],
-      "diffusion":{
-         "plasma->redBloodCells":"kRBC",
-         "redBloodCells->plasma":"kRBC",
-         "kidney->urine":"kU",
-         "slowlyPerfused->hair":"kH",
-         "brainBlood->brain":"kBR",
-         "brain->venous":"kBR",
-         "liver->intestine":"kB",
-         "liver->inorganicMercury":"kI",
-         "intestine->gut":"kR",
-         "intestine->inorganicMercury":"kD",
-         "intestine->feces":"kF",
-         "inorganicMercury->feces":"kIF"}},
-    "pcComments":"always related to outflow of organs", 
-    "partitionCoefficients":{
-       "kidney":"kidneyPCplasma",
-       "richlyPerfused":"richlyPerfusedPCplasma",
-       "fat":"fatPCplasma",
-       "slowlyPerfused":"slowlyPerfusedPCplasma",
-       "brainBlood":"brainBloodPCplasma",
-       "liver":"liverPCplasma",
-       "gut":"gutPCplasma",
-       "brain->venous":"brainPCplasma",
-       "redBloodCells->plasma":"rbcPCplasma"}
-}

models/humanHG_RBC_parameters.json

@@ -1,295 +0,0 @@
-{"parameters":{
-    "bodyWeight":{"value":67.77,"units":"kg","dist":"lognormal","cv":0.26},
-    "bwPower0p75":{"derived":"bwPower0p75"},
-    "commentInputs":"X",
-    "oralIngestion":{"value":0.0486,"unit":"ug/min","dist":"normal","cv":0.1},
-    "commentPC":"X",
-    "bloodToPlasmaPCscale":{"derived":"bloodToPlasmaPCscale"},
-    "rbcPCfraction":{"derived":"rbcPCfraction"},
-    "brainBloodPCplasma":{"value":1,"dist":"lognormal","cv":0.3},
-    "brainPCblood":{"value":3,"dist":"lognormal","cv":0.3},
-    "fatPCblood":{"value":0.15,"dist":"lognormal","cv":0.3},
-    "gutPCblood":{"value":1,"dist":"lognormal","cv":0.7},
-    "kidneyPCblood":{"value":4.0,"dist":"lognormal","cv":0.3},
-    "liverPCblood":{"value":5.0,"dist":"lognormal","cv":0.3},
-    "rbcPCplasma":{"value":12.0,"dist":"lognormal","cv":0.3},
-    "richlyPerfusedPCblood":{"value":1.0,"dist":"lognormal","cv":0.3},
-    "slowlyPerfusedPCblood":{"value":2.0,"dist":"lognormal","cv":0.3},
-    "commentPCplasma":"X",
-    "brainPCplasma":{"derived":"brainPCplasma"},
-    "fatPCplasma":{"derived":"fatPCplasma"},
-    "gutPCplasma":{"derived":"gutPCplasma"},
-    "kidneyPCplasma":{"derived":"kidneyPCplasma"},
-    "liverPCplasma":{"derived":"liverPCplasma"},
-    "richlyPerfusedPCplasma":{"derived":"richlyPerfusedPCplasma"},
-    "slowlyPerfusedPCplasma":{"derived":"slowlyPerfusedPCplasma"},
-    "commentCardiacOutput":"X",
-    "cardiacOutput":{"derived":"cardiacOutput"},
-    "cardiacOutputScaled":{"value":0.333,"unit":"l/min","dist":"normal","cv":0.22},
-    "commentFlows":"X",
-    "plasmaFlow":{"derived":"plasmaFlow"},
-    "kidneyFlow":{"derived":"kidneyFlow"},
-    "richlyPerfusedFlow":{"derived":"richlyPerfusedFlow"},
-    "fatFlow":{"derived":"fatFlow"},
-    "slowlyPerfusedFlow":{"derived":"slowlyPerfusedFlow"},
-    "brainBloodFlow":{"derived":"brainBloodFlow"},
-    "liverInFlow":{"derived":"liverInFlow"},
-    "liverOutFlow":{"derived":"liverOutFlow"},
-    "gutFlow":{"derived":"gutFlow"},
-    "commentFlowFraction":"X",
-    "plasmaFlowFraction":{"value":1},
-    "kidneyFlowFraction":{"value":0.175,"dist":"normal","cv":0.3},
-    "richlyPerfusedFlowFraction":{"value":0.183,"dist":"normal","cv":0.3},
-    "fatFlowFraction":{"value":0.052,"dist":"normal","cv":0.3},
-    "slowlyPerfusedFlowFraction":{"value":0.249,"dist":"normal","cv":0.3},
-    "brainBloodFlowFraction":{"value":0.114,"dist":"normal","cv":0.3},
-    "liverInFlowFraction":{"value":0.046,"dist":"normal","cv":0.32},
-    "commentLiverOutFlow":"sum of liver in and gut",
-    "liverOutFlowFraction":{"value":0.227,"dist":"normal","cv":0.3},
-    "gutFlowFraction":{"value":0.181,"dist":"normal","cv":0.33},
-    "commentVolumes":"X",
-    "plasmaVolume":{"derived":"plasmaVolume"},
-    "venousVolume":{"derived":"venousVolume"},
-    "redBloodCellsVolume":{"derived":"redBloodCellsVolume"},
-    "kidneyVolume":{"derived":"kidneyVolume"},
-    "richlyPerfusedVolume":{"derived":"richlyPerfusedVolume"},
-    "fatVolume":{"derived":"fatVolume"},
-    "slowlyPerfusedVolume":{"derived":"slowlyPerfusedVolume"},
-    "brainBloodVolume":{"derived":"brainBloodVolume"},
-    "brainVolume":{"derived":"brainVolume"},
-    "liverVolume":{"derived":"liverVolume"},
-    "gutVolume":{"derived":"gutVolume"},
-    "intestineVolume":{"derived":"intestineVolume"},
-    "commentFractionsDerived":"X",
-    "plasmaVolumeFractionBlood":{"derived":"plasmaVolumeFractionBlood"},
-    "rbcVolumeFractionBlood":{"derived":"rbcVolumeFractionBlood"},
-    "bloodVolumeFraction":{"derived":"bloodVolumeFraction"},
-    "venousVolumeFraction":{"derived":"venousVolumeFraction"},
-    "plasmaVolumeFraction":{"derived":"plasmaVolumeFraction"},
-    "commentFractions":"X",
-    "plasmaTotalVolumeFraction":{"value":0.04,"dist":"normal","cv":0.14},
-    "redBloodCellsVolumeFraction":{"value":0.024,"dist":"normal","cv":0.25},
-    "kidneyVolumeFraction":{"value":0.004,"dist":"normal","cv":0.3},
-    "richlyPerfusedVolumeFraction":{"value":0.1,"dist":"normal","cv":0.3},
-    "fatVolumeFraction":{"value":0.273,"dist":"normal","cv":0.24},
-    "hairVolumeFraction":{"value":0.002,"dist":"normal","cv":0.5},
-    "slowlyPerfusedVolumeFraction":{"value":0.35,"dist":"normal","cv":0.16},
-    "brainBloodVolumeFraction":{"value":0.007,"dist":"normal","cv":0.3},
-    "brainVolumeFraction":{"value":0.02,"dist":"normal","cv":0.3},
-    "liverVolumeFraction":{"value":0.026,"dist":"normal","cv":0.25},
-    "gutVolumeFraction":{"value":0.017,"dist":"normal","cv":0.15},
-    "intestineVolumeFraction":{"value":0.014,"dist":"normal","cv":0.3},
-    "commentDiff":"X",
-    "kB":{"derived":"kB"},
-    "kBR":{"derived":"kBR"},
-    "kD":{"derived":"kD"},
-    "kF":{"derived":"kF"},
-    "kH":{"derived":"kH"},
-    "kI":{"derived":"kI"},
-    "kIF":{"derived":"kIF"},
-    "kRBC":{"derived":"kRBC"},
-    "kR":{"derived":"kR"},
-    "kU":{"derived":"kU"},
-    "commentDiffScaled":"X",
-    "kBScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
-    "kBRScaled":{"value":1.67e-4,"unit":"l/min","dist":"lognormal","cv":0.3},
-    "kDScaled":{"value":1e-4,"unit":"l/hour","dist":"lognormal","cv":0.3},
-    "kFScaled":{"value":2e-4,"unit":"l/hour","dist":"lognormal","cv":0.36},
-    "kHScaled":{"value":7e-6,"unit":"l/hour","dist":"lognormal","cv":0.25},
-    "kIScaled":{"value":1e-5,"unit":"l/hour","dist":"lognormal","cv":0.3},
-    "kIFScaled":{"value":0,"unit":"l/min","noDist":"lognormal","cv":0.3},
-    "kRBCScaled":{"value":2.5e-2,"unit":"l/min","dist":"lognormal","cv":0.3},
-    "kRScaled":{"value":8.33e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
-    "kUScaled":{"value":0,"unit":"l/min"},
-    "zero":{"value":0},
-    "threeQuarters":{"value":0.75}},
-"derivedParameters":{
-    "bwPower0p75":{
-        "type":"power",
-        "a":"bodyWeight",
-        "n":"threeQuarters"},
-    "cardiacOutput":{
-        "type":"product",
-        "a":"cardiacOutputScaled",
-        "b":"bwPower0p75"},
-    "plasmaFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"plasmaFlowFraction"},
-    "kidneyFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"kidneyFlowFraction"},
-    "richlyPerfusedFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"richlyPerfusedFlowFraction"},
-    "fatFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"fatFlowFraction"},
-    "slowlyPerfusedFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"slowlyPerfusedFlowFraction"},
-    "brainBloodFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"brainBloodFlowFraction"},
-    "liverInFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"liverInFlowFraction"},
-    "liverOutFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"liverOutFlowFraction"},
-    "gutFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"gutFlowFraction"},
-    "bloodToPlasmaPCscale":{
-        "type":"sum",
-        "a":"plasmaVolumeFractionBlood",
-        "b":"rbcPCfraction"},
-    "rbcPCfraction":{
-        "type":"product",
-        "a":"rbcVolumeFractionBlood",
-        "b":"rbcPCplasma"},
-    "brainPCplasma":{
-        "type":"product",
-        "a":"brainPCblood",
-        "b":"bloodToPlasmaPCscale"},
-    "kidneyPCplasma":{
-        "type":"product",
-        "a":"kidneyPCblood",
-        "b":"bloodToPlasmaPCscale"},
-    "richlyPerfusedPCplasma":{
-        "type":"product",
-        "a":"richlyPerfusedPCblood",
-        "b":"bloodToPlasmaPCscale"},
-    "slowlyPerfusedPCplasma":{
-        "type":"product",
-        "a":"slowlyPerfusedPCblood",
-        "b":"bloodToPlasmaPCscale"},
-    "fatPCplasma":{
-        "type":"product",
-        "a":"fatPCblood",
-        "b":"bloodToPlasmaPCscale"},
-    "gutPCplasma":{
-        "type":"product",
-        "a":"gutPCblood",
-        "b":"bloodToPlasmaPCscale"},
-    "liverPCplasma":{
-        "type":"product",
-        "a":"liverPCblood",
-        "b":"bloodToPlasmaPCscale"},
-    "plasmaVolume":{
-        "type":"product",
-        "a":"plasmaVolumeFraction",
-        "b":"bodyWeight"},
-    "venousVolume":{
-        "type":"product",
-        "a":"venousVolumeFraction",
-        "b":"bodyWeight"},
-    "redBloodCellsVolume":{
-        "type":"product",
-        "a":"redBloodCellsVolumeFraction",
-        "b":"bodyWeight"},
-    "kidneyVolume":{
-        "type":"product",
-        "a":"kidneyVolumeFraction",
-        "b":"bodyWeight"},
-    "richlyPerfusedVolume":{
-        "type":"product",
-        "a":"richlyPerfusedVolumeFraction",
-        "b":"bodyWeight"},
-    "fatVolume":{
-        "type":"product",
-        "a":"fatVolumeFraction",
-        "b":"bodyWeight"},
-    "slowlyPerfusedVolume":{
-        "type":"product",
-        "a":"slowlyPerfusedVolumeFraction",
-        "b":"bodyWeight"},
-    "brainBloodVolume":{
-        "type":"product",
-        "a":"brainBloodVolumeFraction",
-        "b":"bodyWeight"},
-    "brainVolume":{
-        "type":"product",
-        "a":"brainVolumeFraction",
-        "b":"bodyWeight"},
-    "liverVolume":{
-        "type":"product",
-        "a":"liverVolumeFraction",
-        "b":"bodyWeight"},
-    "gutVolume":{
-        "type":"product",
-        "a":"gutVolumeFraction",
-        "b":"bodyWeight"},
-    "intestineVolume":{
-        "type":"product",
-        "a":"intestineVolumeFraction",
-        "b":"bodyWeight"},
-    "plasmaVolumeFractionBlood":{
-        "type":"ratio",
-        "a":"plasmaTotalVolumeFraction",
-        "b":"bloodVolumeFraction"},
-    "rbcVolumeFractionBlood":{
-        "type":"ratio",
-        "a":"redBloodCellsVolumeFraction",
-        "b":"bloodVolumeFraction"},
-    "plasmaVolumeFraction":{
-        "type":"ratio",
-        "a":"plasmaTotalVolumeFraction",
-        "b":"two"},
-    "venousVolumeFraction":{
-        "type":"ratio",
-        "a":"plasmaTotalVolumeFraction",
-        "b":"two"},
-    "bloodVolumeFraction":{
-        "type":"sum",
-        "a":"plasmaTotalVolumeFraction",
-        "b":"redBloodCellsVolumeFraction"},
-    "kB":{
-        "type":"product",
-        "a":"kBScaled",
-        "b":"bwPower0p75"},
-    "kBR":{
-        "type":"product",
-        "a":"kBRScaled",
-        "b":"bwPower0p75"},
-    "kD":{
-        "type":"product",
-        "a":"kDScaled",
-        "b":"bwPower0p75"},
-    "kF":{
-        "type":"product",
-        "a":"kFScaled",
-        "b":"bwPower0p75"},
-    "kH":{
-        "type":"product",
-        "a":"kHScaled",
-        "b":"bwPower0p75"},
-    "kI":{
-        "type":"product",
-        "a":"kIScaled",
-        "b":"bwPower0p75"},
-    "kIF":{
-        "type":"product",
-        "a":"kIFScaled",
-        "b":"bwPower0p75"},
-    "kRBC":{
-        "type":"product",
-        "a":"kRBCScaled",
-        "b":"bwPower0p75"},
-    "kR":{
-        "type":"product",
-        "a":"kRScaled",
-        "b":"bwPower0p75"},
-    "kU":{
-        "type":"product",
-        "a":"kUScaled",
-        "b":"bwPower0p75"}}
-}

models/humanHG_parameters.json

@@ -1,48 +0,0 @@
-{"parameters":{
-        "kidneyPC":{"value":4.0},
-        "richlyPerfusedPC":{"value":1},
-        "fatPC":{"value":0.15},
-        "slowlyPerfusedPC":{"value":2},
-        "brainBloodPC":{"value":1},
-        "brainPC":{"value":3},
-        "hairPC":{"value":248.7},
-        "placentaPC":{"value":2},
-	     "liverPC":{"value":5},
-        "gutPC":{"value":1},
-        "rbcPC":{"value":12},
-        "flowNotes":"assuming 70kg individual, fetus at 0.1kg",
-        "plasmaFlow":{"value":8.067,"unit":"l/min"},
-        "kidneyFlow":{"value":1.412,"unit":"l/min"},
-        "richlyPerfusedFlow":{"value":1.484,"unit":"l/min"},
-        "fatFlow":{"value":0.419,"unit":"l/min"},
-        "slowlyPerfusedFlow":{"value":2.01,"unit":"l/min"},
-        "brainBloodFlow":{"value":0.920,"unit":"l/min"},
-        "placentaFlow":{"value":0.173,"unit":"l/min"},
-        "liverInFlow":{"value":0.391,"unit":"l/min"},
-        "liverOutFlow":{"value":1.928,"unit":"l/min"},
-        "gutFlow":{"value":1.538,"unit":"l/min"},
-        "plasmaVolume":{"value":1.64,"unit":"kg"},
-        "redBloodCellsVolume":{"value":1.64,"unit":"kg"},
-        "kidneyVolume":{"value":0.28,"unit":"kg"},
-        "richlyPerfusedVolume":{"value":7,"unit":"kg"},
-        "fatVolume":{"value":19.11,"unit":"kg"},
-        "hairVolume":{"value":0.140,"unit":"kg","dist":"lognormal","cv":0.5},
-        "slowlyPerfusedVolume":{"value":24.5,"unit":"kg"},
-        "brainBloodVolume":{"value":0.49,"unit":"kg"},
-        "brainVolume":{"value":1.4,"unit":"kg"},
-        "placentaVolume":{"value":0.0431,"unit":"kg"},
-        "liverVolume":{"value":1.82,"unit":"kg"},
-        "gutVolume":{"value":1.19,"unit":"kg"},
-        "intestineVolume":{"value":0.98,"unit":"kg"},
-        "kRBC":{"value":0.60,"unit":"l/min"},
-        "kU":{"value":0,"unit":"l/min"},
-        "commentkH":"assume pc-times larger input flow, 2.823e-6*248.7",
-        "kH":{"value":2.823e-6,"unit":"l/min"},
-        "kBR":{"value":4.033e-3,"unit":"l/min"},
-        "kI":{"value":4.033e-6,"unit":"l/min"},
-        "kB":{"value":4.033e-5,"unit":"l/min"},
-        "kD":{"value":4.033e-5,"unit":"l/min"},
-        "kF":{"value":8.066e-5,"unit":"l/min"},
-        "kF1":{"value":0,"unit":"l/min"},
-        "kR":{"value":2.016e-3,"unit":"l/min"}}
-}

models/humanHG_parameters1.json

@@ -1,224 +0,0 @@
-{"parameters":{
-        "bodyWeight":{"value":67.77,"units":"kg","dist":"lognormal","cv":0.26},
-        "bwPower0p75":{"derived":"bwPower0p75"},
-        "commentInputs":"X",
-        "oralIngestion":{"value":0.0486,"unit":"ug/min","dist":"normal","cv":0.1},
-        "commentPC":"X",
-        "brainBloodPC":{"value":1,"dist":"lognormal","cv":0.3},
-        "brainPC":{"value":3,"dist":"lognormal","cv":0.3},
-        "fatPC":{"value":0.15,"dist":"lognormal","cv":0.3},
-        "gutPC":{"value":1,"dist":"lognormal","cv":0.7},
-        "kidneyPC":{"value":4.0,"dist":"lognormal","cv":0.3},
-        "liverPC":{"value":5.0,"dist":"lognormal","cv":0.3},
-        "rbcPC":{"value":12.0,"dist":"lognormal","cv":0.3},
-        "richlyPerfusedPC":{"value":1.0,"dist":"lognormal","cv":0.3},
-        "slowlyPerfusedPC":{"value":2.0,"dist":"lognormal","cv":0.3},
-        "commentCardiacOutput":"X",
-        "cardiacOutput":{"derived":"cardiacOutput"},
-        "cardiacOutputScaled":{"value":0.333,"unit":"l/min","dist":"normal","cv":0.22},
-        "commentFlows":"X",
-        "plasmaFlow":{"derived":"plasmaFlow"},
-        "kidneyFlow":{"derived":"kidneyFlow"},
-        "richlyPerfusedFlow":{"derived":"richlyPerfusedFlow"},
-        "fatFlow":{"derived":"fatFlow"},
-        "slowlyPerfusedFlow":{"derived":"slowlyPerfusedFlow"},
-        "brainBloodFlow":{"derived":"brainBloodFlow"},
-        "liverInFlow":{"derived":"liverInFlow"},
-        "liverOutFlow":{"derived":"liverOutFlow"},
-        "gutFlow":{"derived":"gutFlow"},
-        "commentFlowFraction":"X",
-        "plasmaFlowFraction":{"value":1},
-        "kidneyFlowFraction":{"value":0.175,"dist":"normal","cv":0.3},
-        "richlyPerfusedFlowFraction":{"value":0.183,"dist":"normal","cv":0.3},
-        "fatFlowFraction":{"value":0.052,"dist":"normal","cv":0.3},
-        "slowlyPerfusedFlowFraction":{"value":0.249,"dist":"normal","cv":0.3},
-        "brainBloodFlowFraction":{"value":0.114,"dist":"normal","cv":0.3},
-        "liverInFlowFraction":{"value":0.046,"dist":"normal","cv":0.32},
-        "commentLiverOutFlow":"sum of liver in and gut",
-        "liverOutFlowFraction":{"value":0.227,"dist":"normal","cv":0.3},
-        "gutFlowFraction":{"value":0.181,"dist":"normal","cv":0.33},
-        "commentVolumes":"X",
-        "plasmaVolume":{"derived":"plasmaVolume"},
-        "venousVolume":{"derived":"venousVolume"},
-        "redBloodCellsVolume":{"derived":"redBloodCellsVolume"},
-        "kidneyVolume":{"derived":"kidneyVolume"},
-        "richlyPerfusedVolume":{"derived":"richlyPerfusedVolume"},
-        "fatVolume":{"derived":"fatVolume"},
-        "slowlyPerfusedVolume":{"derived":"slowlyPerfusedVolume"},
-        "brainBloodVolume":{"derived":"brainBloodVolume"},
-        "brainVolume":{"derived":"brainVolume"},
-        "liverVolume":{"derived":"liverVolume"},
-        "gutVolume":{"derived":"gutVolume"},
-        "intestineVolume":{"derived":"intestineVolume"},
-        "commentFractions":"X",
-        "plasmaVolumeFraction":{"value":0.012,"dist":"normal","cv":0.14},
-        "venousVolumeFraction":{"value":0.012,"dist":"normal","cv":0.14},
-        "redBloodCellsVolumeFraction":{"value":0.024,"dist":"normal","cv":0.25},
-        "kidneyVolumeFraction":{"value":0.004,"dist":"normal","cv":0.3},
-        "richlyPerfusedVolumeFraction":{"value":0.1,"dist":"normal","cv":0.3},
-        "fatVolumeFraction":{"value":0.273,"dist":"normal","cv":0.24},
-        "hairVolumeFraction":{"value":0.002,"dist":"normal","cv":0.5},
-        "slowlyPerfusedVolumeFraction":{"value":0.35,"dist":"normal","cv":0.16},
-        "brainBloodVolumeFraction":{"value":0.007,"dist":"normal","cv":0.3},
-        "brainVolumeFraction":{"value":0.02,"dist":"normal","cv":0.3},
-        "liverVolumeFraction":{"value":0.026,"dist":"normal","cv":0.25},
-        "gutVolumeFraction":{"value":0.017,"dist":"normal","cv":0.15},
-        "intestineVolumeFraction":{"value":0.014,"dist":"normal","cv":0.3},
-        "commentDiff":"X",
-        "kB":{"derived":"kB"},
-        "kBR":{"derived":"kBR"},
-        "kD":{"derived":"kD"},
-        "kF":{"derived":"kF"},
-        "kH":{"derived":"kH"},
-        "kI":{"derived":"kI"},
-        "kIF":{"derived":"kIF"},
-        "kRBC":{"derived":"kRBC"},
-        "kR":{"derived":"kR"},
-        "kU":{"derived":"kU"},
-        "commentDiffScaled":"X",
-        "kBScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kBRScaled":{"value":1.67e-4,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kDScaled":{"value":1e-4,"unit":"l/hour","dist":"lognormal","cv":0.3},
-        "kFScaled":{"value":2e-4,"unit":"l/hour","dist":"lognormal","cv":0.36},
-        "kHScaled":{"value":7e-6,"unit":"l/hour","dist":"lognormal","cv":0.25},
-        "kIScaled":{"value":1e-5,"unit":"l/hour","dist":"lognormal","cv":0.3},
-        "kIFScaled":{"value":0,"unit":"l/min","noDist":"lognormal","cv":0.3},
-        "kRBCScaled":{"value":2.5e-2,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kRScaled":{"value":8.33e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kUScaled":{"value":0,"unit":"l/min"},
-        "zero":{"value":0},
-        "threeQuarters":{"value":0.75}},
-    "derivedParameters":{
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-          "type":"power",
-          "a":"bodyWeight",
-          "n":"threeQuarters"},
-       "cardiacOutput":{
-          "type":"product",
-          "a":"cardiacOutputScaled",
-          "b":"bwPower0p75"},
-        "plasmaFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"plasmaFlowFraction"},
-        "kidneyFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"kidneyFlowFraction"},
-        "richlyPerfusedFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"richlyPerfusedFlowFraction"},
-        "fatFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"fatFlowFraction"},
-        "slowlyPerfusedFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"slowlyPerfusedFlowFraction"},
-        "brainBloodFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"brainBloodFlowFraction"},
-        "liverInFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"liverInFlowFraction"},
-        "liverOutFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"liverOutFlowFraction"},
-        "gutFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"gutFlowFraction"},
-        "plasmaVolume":{
-           "type":"product",
-           "a":"plasmaVolumeFraction",
-           "b":"bodyWeight"},
-        "venousVolume":{
-           "type":"product",
-           "a":"venousVolumeFraction",
-           "b":"bodyWeight"},
-        "redBloodCellsVolume":{
-           "type":"product",
-           "a":"redBloodCellsVolumeFraction",
-           "b":"bodyWeight"},
-        "kidneyVolume":{
-           "type":"product",
-           "a":"kidneyVolumeFraction",
-           "b":"bodyWeight"},
-        "richlyPerfusedVolume":{
-           "type":"product",
-           "a":"richlyPerfusedVolumeFraction",
-           "b":"bodyWeight"},
-        "fatVolume":{
-           "type":"product",
-           "a":"fatVolumeFraction",
-           "b":"bodyWeight"},
-        "slowlyPerfusedVolume":{
-           "type":"product",
-           "a":"slowlyPerfusedVolumeFraction",
-           "b":"bodyWeight"},
-        "brainBloodVolume":{
-           "type":"product",
-           "a":"brainBloodVolumeFraction",
-           "b":"bodyWeight"},
-        "brainVolume":{
-           "type":"product",
-           "a":"brainVolumeFraction",
-           "b":"bodyWeight"},
-        "liverVolume":{
-           "type":"product",
-           "a":"liverVolumeFraction",
-           "b":"bodyWeight"},
-        "gutVolume":{
-           "type":"product",
-           "a":"gutVolumeFraction",
-           "b":"bodyWeight"},
-        "intestineVolume":{
-           "type":"product",
-           "a":"intestineVolumeFraction",
-           "b":"bodyWeight"},
-       "kB":{
-          "type":"product",
-          "a":"kBScaled",
-          "b":"bwPower0p75"},
-       "kBR":{
-          "type":"product",
-          "a":"kBRScaled",
-          "b":"bwPower0p75"},
-       "kD":{
-          "type":"product",
-          "a":"kDScaled",
-          "b":"bwPower0p75"},
-       "kF":{
-          "type":"product",
-          "a":"kFScaled",
-          "b":"bwPower0p75"},
-       "kH":{
-          "type":"product",
-          "a":"kHScaled",
-          "b":"bwPower0p75"},
-       "kI":{
-          "type":"product",
-          "a":"kIScaled",
-          "b":"bwPower0p75"},
-       "kIF":{
-          "type":"product",
-          "a":"kIFScaled",
-          "b":"bwPower0p75"},
-       "kRBC":{
-          "type":"product",
-          "a":"kRBCScaled",
-          "b":"bwPower0p75"},
-       "kR":{
-          "type":"product",
-          "a":"kRScaled",
-          "b":"bwPower0p75"},
-       "kU":{
-          "type":"product",
-          "a":"kUScaled",
-          "b":"bwPower0p75"}}
-}

models/humanHG_parameters2.json

@@ -1,254 +0,0 @@
-{"parameters":{
-        "bodyWeight":{"value":67.77,"units":"kg","dist":"lognormal","cv":0.26},
-        "bwPower0p75":{"derived":"bwPower0p75"},
-        "commentPC":"X",
-        "brainBloodPC":{"value":1,"dist":"lognormal","cv":0.3},
-        "brainPC":{"value":3,"dist":"lognormal","cv":0.3},
-        "fatPC":{"value":0.15,"dist":"lognormal","cv":0.3},
-        "gutPC":{"value":1,"dist":"lognormal","cv":0.7},
-        "hairPC":{"derived":"hairPC"},
-        "hairPCBlood":{"value":248.7,"dist":"lognormal","cv":0.7},
-        "kidneyPC":{"value":4.0,"dist":"lognormal","cv":0.3},
-        "liverPC":{"value":5.0,"dist":"lognormal","cv":0.3},
-        "rbcPC":{"value":12.0,"dist":"lognormal","cv":0.3},
-        "richlyPerfusedPC":{"value":1.0,"dist":"lognormal","cv":0.3},
-        "slowlyPerfusedPC":{"value":2.0,"dist":"lognormal","cv":0.3},
-        "commentCardiacOutput":"X",
-        "cardiacOutput":{"derived":"cardiacOutput"},
-        "cardiacOutputScaled":{"value":0.333,"unit":"l/min","dist":"normal","cv":0.22},
-        "commentFlows":"X",
-        "plasmaFlow":{"derived":"plasmaFlow"},
-        "kidneyFlow":{"derived":"kidneyFlow"},
-        "richlyPerfusedFlow":{"derived":"richlyPerfusedFlow"},
-        "fatFlow":{"derived":"fatFlow"},
-        "slowlyPerfusedFlow":{"derived":"slowlyPerfusedFlow"},
-        "brainBloodFlow":{"derived":"brainBloodFlow"},
-        "liverInFlow":{"derived":"liverInFlow"},
-        "liverOutFlow":{"derived":"liverOutFlow"},
-        "gutFlow":{"derived":"gutFlow"},
-        "commentFlowFraction":"X",
-        "plasmaFlowFraction":{"value":1},
-        "kidneyFlowFraction":{"value":0.175,"dist":"normal","cv":0.3},
-        "richlyPerfusedFlowFraction":{"value":0.183,"dist":"normal","cv":0.3},
-        "fatFlowFraction":{"value":0.052,"dist":"normal","cv":0.3},
-        "slowlyPerfusedFlowFraction":{"value":0.249,"dist":"normal","cv":0.3},
-        "brainBloodFlowFraction":{"value":0.114,"dist":"normal","cv":0.3},
-        "liverInFlowFraction":{"value":0.046,"dist":"normal","cv":0.32},
-        "commentLiverOutFlow":"sum of liver in and gut",
-        "liverOutFlowFraction":{"value":0.227,"dist":"normal","cv":0.3},
-        "gutFlowFraction":{"value":0.181,"dist":"normal","cv":0.33},
-        "commentVolumes":"X",
-        "plasmaVolume":{"derived":"plasmaVolume"},
-        "redBloodCellsVolume":{"derived":"redBloodCellsVolume"},
-        "kidneyVolume":{"derived":"kidneyVolume"},
-        "richlyPerfusedVolume":{"derived":"richlyPerfusedVolume"},
-        "fatVolume":{"derived":"fatVolume"},
-        "hairVolume":{"function":"hairGrowth"},
-        "hairGrowthDuration":{"derived":"hairGrowthDuration"},
-        "hairVolumeMax":{"derived":"hairVolumeMax"},
-        "slowlyPerfusedVolume":{"derived":"slowlyPerfusedVolume"},
-        "brainBloodVolume":{"derived":"brainBloodVolume"},
-        "brainVolume":{"derived":"brainVolume"},
-        "liverVolume":{"derived":"liverVolume"},
-        "gutVolume":{"derived":"gutVolume"},
-        "intestineVolume":{"derived":"intestineVolume"},
-        "commentFractions":"X",
-        "plasmaVolumeFraction":{"value":0.024,"dist":"normal","cv":0.14},
-        "redBloodCellsVolumeFraction":{"value":0.024,"dist":"normal","cv":0.25},
-        "kidneyVolumeFraction":{"value":0.004,"dist":"normal","cv":0.3},
-        "richlyPerfusedVolumeFraction":{"value":0.1,"dist":"normal","cv":0.3},
-        "fatVolumeFraction":{"value":0.273,"dist":"normal","cv":0.24},
-        "hairVolumeFraction":{"value":0.002,"dist":"normal","cv":0.5},
-        "slowlyPerfusedVolumeFraction":{"value":0.35,"dist":"normal","cv":0.16},
-        "brainBloodVolumeFraction":{"value":0.007,"dist":"normal","cv":0.3},
-        "brainVolumeFraction":{"value":0.02,"dist":"normal","cv":0.3},
-        "liverVolumeFraction":{"value":0.026,"dist":"normal","cv":0.25},
-        "gutVolumeFraction":{"value":0.017,"dist":"normal","cv":0.15},
-        "intestineVolumeFraction":{"value":0.14,"dist":"normal","cv":0.3},
-        "commentDiff":"X",
-        "kB":{"derived":"kB"},
-        "kBR":{"derived":"kBR"},
-        "kD":{"derived":"kD"},
-        "kF":{"derived":"kF"},
-        "kH":{"derived":"kH"},
-        "kI":{"derived":"kI"},
-        "kIF":{"derived":"kIF"},
-        "kRBC":{"derived":"kRBC"},
-        "kR":{"derived":"kR"},
-        "kU":{"derived":"kU"},
-        "commentDiffScaled":"X",
-        "kBScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kBRScaled":{"value":1.67e-4,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kDScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kFScaled":{"value":3.33e-6,"unit":"l/min","dist":"lognormal","cv":0.36},
-        "kHScaled":{"value":1.17e-7,"unit":"l/min","dist":"lognormal","cv":0.25},
-        "kIScaled":{"value":1.67e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kIFScaled":{"value":0,"unit":"l/min","noDist":"lognormal","cv":0.3},
-        "kRBCScaled":{"value":2.5e-2,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kRScaled":{"value":8.33e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kUScaled":{"value":0,"unit":"l/min"},
-        "zero":{"value":0},
-        "threeQuarters":{"value":0.75},
-        "heavisideTransition":{"value":100},
-        "hairGrowthStart":{"value":0e6,"unit":"min"},
-        "hairGrowthStop":{"derived":"hairGrowthStop"},
-        "hairGrowth":{"derived":"hairGrowth"}},
-    "functions":{
-       "commentHairGrowth":"2yr hair growth to a total mass of 140g",
-       "hairGrowth":{
-           "type":"linearGrowth",
-           "t1":"hairGrowthStart",
-           "W1":"heavisideTransition",
-           "t2":"hairGrowthStop",
-           "W2":"heavisideTransition",
-           "C":"hairVolumeMax"}},
-    "derivedParameters":{
-       "bwPower0p75":{
-          "type":"power",
-          "a":"bodyWeight",
-          "n":"threeQuarters"},
-       "cardiacOutput":{
-          "type":"product",
-          "a":"cardiacOutputScaled",
-          "b":"bwPower0p75"},
-        "plasmaFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"plasmaFlowFraction"},
-        "kidneyFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"kidneyFlowFraction"},
-        "richlyPerfusedFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"richlyPerfusedFlowFraction"},
-        "fatFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"fatFlowFraction"},
-        "slowlyPerfusedFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"slowlyPerfusedFlowFraction"},
-        "brainBloodFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"brainBloodFlowFraction"},
-        "liverInFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"liverInFlowFraction"},
-        "liverOutFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"liverOutFlowFraction"},
-        "gutFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"gutFlowFraction"},
-        "plasmaVolume":{
-           "type":"product",
-           "a":"plasmaVolumeFraction",
-           "b":"bodyWeight"},
-        "redBloodCellsVolume":{
-           "type":"product",
-           "a":"redBloodCellsVolumeFraction",
-           "b":"bodyWeight"},
-        "kidneyVolume":{
-           "type":"product",
-           "a":"kidneyVolumeFraction",
-           "b":"bodyWeight"},
-        "richlyPerfusedVolume":{
-           "type":"product",
-           "a":"richlyPerfusedVolumeFraction",
-           "b":"bodyWeight"},
-        "fatVolume":{
-           "type":"product",
-           "a":"fatVolumeFraction",
-           "b":"bodyWeight"},
-        "slowlyPerfusedVolume":{
-           "type":"product",
-           "a":"slowlyPerfusedVolumeFraction",
-           "b":"bodyWeight"},
-        "brainBloodVolume":{
-           "type":"product",
-           "a":"brainBloodVolumeFraction",
-           "b":"bodyWeight"},
-        "brainVolume":{
-           "type":"product",
-           "a":"brainVolumeFraction",
-           "b":"bodyWeight"},
-        "liverVolume":{
-           "type":"product",
-           "a":"liverVolumeFraction",
-           "b":"bodyWeight"},
-        "gutVolume":{
-           "type":"product",
-           "a":"gutVolumeFraction",
-           "b":"bodyWeight"},
-        "intestineVolume":{
-           "type":"product",
-           "a":"intestineVolumeFraction",
-           "b":"bodyWeight"},
-       "hairVolumeMax":{
-           "type":"product",
-           "a":"hairVolumeFraction",
-           "b":"bodyWeight"},
-       "hairGrowthStop":{
-           "type":"sum",
-           "a":"hairGrowthStart",
-           "b":"hairGrowthDuration"},
-       "hairGrowthDuration":{
-            "type":"ratio",
-            "a":"hairVolumeMax",
-            "b":"hairGrowth"},
-       "hairGrowth":{
-            "type":"ratio",
-            "a":"kH",
-            "b":"hairPC"},
-       "hairPC":{
-          "type":"ratio",
-          "a":"hairPCBlood",
-          "b":"slowlyPerfusedPC"},
-       "kB":{
-          "type":"product",
-          "a":"kBScaled",
-          "b":"bwPower0p75"},
-       "kBR":{
-          "type":"product",
-          "a":"kBRScaled",
-          "b":"bwPower0p75"},
-       "kD":{
-          "type":"product",
-          "a":"kDScaled",
-          "b":"bwPower0p75"},
-       "kF":{
-          "type":"product",
-          "a":"kFScaled",
-          "b":"bwPower0p75"},
-       "kH":{
-          "type":"product",
-          "a":"kHScaled",
-          "b":"bwPower0p75"},
-       "kI":{
-          "type":"product",
-          "a":"kIScaled",
-          "b":"bwPower0p75"},
-       "kIF":{
-          "type":"product",
-          "a":"kIFScaled",
-          "b":"bwPower0p75"},
-       "kRBC":{
-          "type":"product",
-          "a":"kRBCScaled",
-          "b":"bwPower0p75"},
-       "kR":{
-          "type":"product",
-          "a":"kRScaled",
-          "b":"bwPower0p75"},
-       "kU":{
-          "type":"product",
-          "a":"kUScaled",
-          "b":"bwPower0p75"}}
-}

models/humanHG_parameters5.json

@@ -1,254 +0,0 @@
-{"parameters":{
-        "bodyWeight":{"value":67.77,"units":"kg","dist":"lognormal","cv":0.26},
-        "bwPower0p75":{"derived":"bwPower0p75"},
-        "commentPC":"X",
-        "brainBloodPC":{"value":1,"dist":"lognormal","cv":0.3},
-        "brainPC":{"value":3,"dist":"lognormal","cv":0.3},
-        "fatPC":{"value":0.15,"dist":"lognormal","cv":0.3},
-        "gutPC":{"value":1,"dist":"lognormal","cv":0.7},
-        "hairPC":{"derived":"hairPC"},
-        "hairPCBlood":{"value":248.7,"dist":"lognormal","cv":0.7},
-        "kidneyPC":{"value":4.0,"dist":"lognormal","cv":0.3},
-        "liverPC":{"value":5.0,"dist":"lognormal","cv":0.3},
-        "rbcPC":{"value":12.0,"dist":"lognormal","cv":0.3},
-        "richlyPerfusedPC":{"value":1.0,"dist":"lognormal","cv":0.3},
-        "slowlyPerfusedPC":{"value":2.0,"dist":"lognormal","cv":0.3},
-        "commentCardiacOutput":"X",
-        "cardiacOutput":{"derived":"cardiacOutput"},
-        "cardiacOutputScaled":{"value":0.333,"unit":"l/min","dist":"normal","cv":0.22},
-        "commentFlows":"X",
-        "plasmaFlow":{"derived":"plasmaFlow"},
-        "kidneyFlow":{"derived":"kidneyFlow"},
-        "richlyPerfusedFlow":{"derived":"richlyPerfusedFlow"},
-        "fatFlow":{"derived":"fatFlow"},
-        "slowlyPerfusedFlow":{"derived":"slowlyPerfusedFlow"},
-        "brainBloodFlow":{"derived":"brainBloodFlow"},
-        "liverInFlow":{"derived":"liverInFlow"},
-        "liverOutFlow":{"derived":"liverOutFlow"},
-        "gutFlow":{"derived":"gutFlow"},
-        "commentFlowFraction":"X",
-        "plasmaFlowFraction":{"value":1},
-        "kidneyFlowFraction":{"value":0.175,"dist":"normal","cv":0.3},
-        "richlyPerfusedFlowFraction":{"value":0.183,"dist":"normal","cv":0.3},
-        "fatFlowFraction":{"value":0.052,"dist":"normal","cv":0.3},
-        "slowlyPerfusedFlowFraction":{"value":0.249,"dist":"normal","cv":0.3},
-        "brainBloodFlowFraction":{"value":0.114,"dist":"normal","cv":0.3},
-        "liverInFlowFraction":{"value":0.046,"dist":"normal","cv":0.32},
-        "commentLiverOutFlow":"sum of liver in and gut",
-        "liverOutFlowFraction":{"value":0.227,"dist":"normal","cv":0.3},
-        "gutFlowFraction":{"value":0.181,"dist":"normal","cv":0.33},
-        "commentVolumes":"X",
-        "plasmaVolume":{"derived":"plasmaVolume"},
-        "redBloodCellsVolume":{"derived":"redBloodCellsVolume"},
-        "kidneyVolume":{"derived":"kidneyVolume"},
-        "richlyPerfusedVolume":{"derived":"richlyPerfusedVolume"},
-        "fatVolume":{"derived":"fatVolume"},
-        "hairVolume":{"function":"hairGrowth"},
-        "hairGrowthDuration":{"derived":"hairGrowthDuration"},
-        "hairVolumeMax":{"derived":"hairVolumeMax"},
-        "slowlyPerfusedVolume":{"derived":"slowlyPerfusedVolume"},
-        "brainBloodVolume":{"derived":"brainBloodVolume"},
-        "brainVolume":{"derived":"brainVolume"},
-        "liverVolume":{"derived":"liverVolume"},
-        "gutVolume":{"derived":"gutVolume"},
-        "intestineVolume":{"derived":"intestineVolume"},
-        "commentFractions":"X",
-        "plasmaVolumeFraction":{"value":0.024,"dist":"normal","cv":0.14},
-        "redBloodCellsVolumeFraction":{"value":0.024,"dist":"normal","cv":0.25},
-        "kidneyVolumeFraction":{"value":0.004,"dist":"normal","cv":0.3},
-        "richlyPerfusedVolumeFraction":{"value":0.1,"dist":"normal","cv":0.3},
-        "fatVolumeFraction":{"value":0.273,"dist":"normal","cv":0.24},
-        "hairVolumeFraction":{"value":0.002,"dist":"normal","cv":0.5},
-        "slowlyPerfusedVolumeFraction":{"value":0.35,"dist":"normal","cv":0.16},
-        "brainBloodVolumeFraction":{"value":0.007,"dist":"normal","cv":0.3},
-        "brainVolumeFraction":{"value":0.02,"dist":"normal","cv":0.3},
-        "liverVolumeFraction":{"value":0.026,"dist":"normal","cv":0.25},
-        "gutVolumeFraction":{"value":0.017,"dist":"normal","cv":0.15},
-        "intestineVolumeFraction":{"value":0.14,"dist":"normal","cv":0.3},
-        "commentDiff":"X",
-        "kB":{"derived":"kB"},
-        "kBR":{"derived":"kBR"},
-        "kD":{"derived":"kD"},
-        "kF":{"derived":"kF"},
-        "kH":{"derived":"kH"},
-        "kI":{"derived":"kI"},
-        "kIF":{"derived":"kIF"},
-        "kRBC":{"derived":"kRBC"},
-        "kR":{"derived":"kR"},
-        "kU":{"derived":"kU"},
-        "commentDiffScaled":"X",
-        "kBScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kBRScaled":{"value":1.67e-4,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kDScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kFScaled":{"value":3.33e-6,"unit":"l/min","dist":"lognormal","cv":0.36},
-        "kHScaled":{"value":1.17e-7,"unit":"l/min","dist":"lognormal","cv":0.25},
-        "kIScaled":{"value":1.67e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kIFScaled":{"value":0,"unit":"l/min","noDist":"lognormal","cv":0.3},
-        "kRBCScaled":{"value":2.5e-2,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kRScaled":{"value":8.33e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kUScaled":{"value":0,"unit":"l/min"},
-        "zero":{"value":0},
-        "threeQuarters":{"value":0.75},
-        "heavisideTransition":{"value":100},
-        "hairGrowthStart":{"value":0e6,"unit":"min"},
-        "hairGrowthStop":{"derived":"hairGrowthStop"},
-        "hairGrowth":{"derived":"hairGrowth"}},
-    "functions":{
-       "commentHairGrowth":"2yr hair growth to a total mass of 140g",
-       "hairGrowth":{
-           "type":"linearGrowth",
-           "t1":"hairGrowthStart",
-           "W1":"heavisideTransition",
-           "t2":"hairGrowthStop",
-           "W2":"heavisideTransition",
-           "C":"hairVolumeMax"}},
-    "derivedParameters":{
-       "bwPower0p75":{
-          "type":"power",
-          "a":"bodyWeight",
-          "n":"threeQuarters"},
-       "cardiacOutput":{
-          "type":"product",
-          "a":"cardiacOutputScaled",
-          "b":"bwPower0p75"},
-        "plasmaFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"plasmaFlowFraction"},
-        "kidneyFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"kidneyFlowFraction"},
-        "richlyPerfusedFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"richlyPerfusedFlowFraction"},
-        "fatFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"fatFlowFraction"},
-        "slowlyPerfusedFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"slowlyPerfusedFlowFraction"},
-        "brainBloodFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"brainBloodFlowFraction"},
-        "liverInFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"liverInFlowFraction"},
-        "liverOutFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"liverOutFlowFraction"},
-        "gutFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"gutFlowFraction"},
-        "plasmaVolume":{
-           "type":"product",
-           "a":"plasmaVolumeFraction",
-           "b":"bodyWeight"},
-        "redBloodCellsVolume":{
-           "type":"product",
-           "a":"redBloodCellsVolumeFraction",
-           "b":"bodyWeight"},
-        "kidneyVolume":{
-           "type":"product",
-           "a":"kidneyVolumeFraction",
-           "b":"bodyWeight"},
-        "richlyPerfusedVolume":{
-           "type":"product",
-           "a":"richlyPerfusedVolumeFraction",
-           "b":"bodyWeight"},
-        "fatVolume":{
-           "type":"product",
-           "a":"fatVolumeFraction",
-           "b":"bodyWeight"},
-        "slowlyPerfusedVolume":{
-           "type":"product",
-           "a":"slowlyPerfusedVolumeFraction",
-           "b":"bodyWeight"},
-        "brainBloodVolume":{
-           "type":"product",
-           "a":"brainBloodVolumeFraction",
-           "b":"bodyWeight"},
-        "brainVolume":{
-           "type":"product",
-           "a":"brainVolumeFraction",
-           "b":"bodyWeight"},
-        "liverVolume":{
-           "type":"product",
-           "a":"liverVolumeFraction",
-           "b":"bodyWeight"},
-        "gutVolume":{
-           "type":"product",
-           "a":"gutVolumeFraction",
-           "b":"bodyWeight"},
-        "intestineVolume":{
-           "type":"product",
-           "a":"intestineVolumeFraction",
-           "b":"bodyWeight"},
-       "hairVolumeMax":{
-           "type":"product",
-           "a":"hairVolumeFraction",
-           "b":"bodyWeight"},
-       "hairGrowthStop":{
-           "type":"sum",
-           "a":"hairGrowthStart",
-           "b":"hairGrowthDuration"},
-       "hairGrowthDuration":{
-            "type":"ratio",
-            "a":"hairVolumeMax",
-            "b":"hairGrowth"},
-       "hairGrowth":{
-            "type":"ratio",
-            "a":"kH",
-            "b":"hairPC"},
-       "hairPC":{
-          "type":"ratio",
-          "a":"hairPCBlood",
-          "b":"slowlyPerfusedPC"},
-       "kB":{
-          "type":"product",
-          "a":"kBScaled",
-          "b":"bwPower0p75"},
-       "kBR":{
-          "type":"product",
-          "a":"kBRScaled",
-          "b":"bwPower0p75"},
-       "kD":{
-          "type":"product",
-          "a":"kDScaled",
-          "b":"bwPower0p75"},
-       "kF":{
-          "type":"product",
-          "a":"kFScaled",
-          "b":"bwPower0p75"},
-       "kH":{
-          "type":"product",
-          "a":"kHScaled",
-          "b":"bwPower0p75"},
-       "kI":{
-          "type":"product",
-          "a":"kIScaled",
-          "b":"bwPower0p75"},
-       "kIF":{
-          "type":"product",
-          "a":"kIFScaled",
-          "b":"bwPower0p75"},
-       "kRBC":{
-          "type":"product",
-          "a":"kRBCScaled",
-          "b":"bwPower0p75"},
-       "kR":{
-          "type":"product",
-          "a":"kRScaled",
-          "b":"bwPower0p75"},
-       "kU":{
-          "type":"product",
-          "a":"kUScaled",
-          "b":"bwPower0p75"}}
-}

models/humanHG_pregnancy.json

@@ -1,76 +0,0 @@
-{
-   "timeUnit":"min",
-   "compartments":[
-      "redBloodCells","plasma","venous","kidney","urine",
-      "richlyPerfused","fat","slowlyPerfused","hair",
-      "brainBlood","brain","placenta",
-      "liver","gut","intestine","feces","inorganicMercury"],
-   "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
-   "volumeComment":"in a compartment w/o volume, value is mass",
-   "volumes":{
-      "plasma":"plasmaVolume",
-      "venous":"plasmaVolume",
-      "kidney":"kidneyVolume",
-      "richlyPerfused":"richlyPerfusedVolume",
-      "fat":"fatVolume",
-      "slowlyPerfused":"slowlyPerfusedVolume",
-      "brainBlood":"brainBloodVolume",
-      "placenta":"placentaVolume",
-      "gut":"gutVolume",
-      "intestine":"intestineVolume",
-      "redBloodCells":"redBloodCellsVolume",
-      "hair":"hairVolume",
-      "brain":"brainVolume",
-      "liver":"liverVolume"
-      },
-   "flows":{
-      "(plasma,venous):kidney":"kidneyFlow",
-      "(plasma,venous):richlyPerfused":"richlyPerfusedFlow",
-      "(plasma,venous):fat":"fatFlow",
-      "(plasma,venous):slowlyPerfused":"slowlyPerfusedFlow",
-      "(plasma,venous):brainBlood":"brainBloodFlow",
-      "(plasma,venous):placenta":"placentaFlow",
-      "plasma:liver":"liverInFlow",
-      "liver:venous":"liverOutFlow",
-      "(plasma,liver):gut":"gutFlow",
-      "plasma:venous":"plasmaFlow"},
-   "commentSources":"constants in concentration units per s",
-   "commentHeavyside":"value is mass of exogene/volume of container/duration",
-   "sources":{
-      "intestine":{"name":"constant","value":0.0486,"unit":"ug/min"}},
-   "commentBindings":"split to flow and diffusion dominated",
-   "bindings": {
-      "flowComments":"group common sources or targets with brackets",
-      "flow":[
-         "(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver)->venous",
-         "gut->liver",
-         "plasma->(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver,gut)",
-         "venous->plasma"],
-      "diffusion":{
-         "plasma->redBloodCells":"kRBC",
-         "redBloodCells->plasma":"kRBC",
-         "kidney->urine":"kU",
-         "slowlyPerfused->hair":"kH",
-         "hair->venous":"kH",
-         "brainBlood->brain":"kBR",
-         "liver->intestine":"kB",
-         "liver->inorganicMercury":"kI",
-         "intestine->gut":"kR",
-         "intestine->inorganicMercury":"kD",
-         "intestine->feces":"kF",
-         "inorganicMercury->feces":"kF1"}},
-    "pcComments":"always related to outflow of organs", 
-    "partitionCoefficients":{
-       "kidney":"kidneyPC",
-       "richlyPerfused":"richlyPerfusedPC",
-       "fat":"fatPC",
-       "slowlyPerfused":"slowlyPerfusedPC",
-       "brainBlood":"brainBloodPC",
-       "placenta":"placentaPC",
-       "liver":"liverPC",
-       "gut":"gutPC",
-       "brainBlood->brain":"brainPC",
-       "hair->venous":"hairPC",
-       "redBloodCells->plasma":"rbcPC"},
-     "parameters":"humanHG_parameters1.json"
-}

models/humanHG_withHairPC.json

@@ -1,73 +0,0 @@
-{
-   "timeUnit":"min",
-   "compartments":[
-      "redBloodCells","plasma","venous","kidney","urine",
-      "richlyPerfused","fat","slowlyPerfused","hair",
-      "brainBlood","brain",
-      "liver","gut","intestine","feces","inorganicMercury"],
-   "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
-   "volumeComment":"in a compartment w/o volume, value is mass",
-   "volumes":{
-      "plasma":"plasmaVolume",
-      "venous":"plasmaVolume",
-      "kidney":"kidneyVolume",
-      "richlyPerfused":"richlyPerfusedVolume",
-      "fat":"fatVolume",
-      "slowlyPerfused":"slowlyPerfusedVolume",
-      "brainBlood":"brainBloodVolume",
-      "gut":"gutVolume",
-      "intestine":"intestineVolume",
-      "redBloodCells":"redBloodCellsVolume",
-      "hair":"hairVolume",
-      "brain":"brainVolume",
-      "liver":"liverVolume"
-      },
-   "flows":{
-      "(plasma,venous):kidney":"kidneyFlow",
-      "(plasma,venous):richlyPerfused":"richlyPerfusedFlow",
-      "(plasma,venous):fat":"fatFlow",
-      "(plasma,venous):slowlyPerfused":"slowlyPerfusedFlow",
-      "(plasma,venous):brainBlood":"brainBloodFlow",
-      "plasma:liver":"liverInFlow",
-      "liver:venous":"liverOutFlow",
-      "(plasma,liver):gut":"gutFlow",
-      "plasma:venous":"plasmaFlow"},
-   "commentSources":"constants in concentration units per s",
-   "commentHeavyside":"value is mass of exogene/volume of container/duration",
-   "sources":{
-      "intestine":{"name":"constant","value":0.0486,"unit":"ug/min"}},
-   "commentBindings":"split to flow and diffusion dominated",
-   "bindings": {
-      "flowComments":"group common sources or targets with brackets",
-      "flow":[
-         "(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,liver)->venous",
-         "gut->liver",
-         "plasma->(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,liver,gut)",
-         "venous->plasma"],
-      "diffusion":{
-         "plasma->redBloodCells":"kRBC",
-         "redBloodCells->plasma":"kRBC",
-         "kidney->urine":"kU",
-         "slowlyPerfused->hair":"kH",
-         "hair->dump":"kH",
-         "brainBlood->brain":"kBR",
-         "brain->venous":"kBR",
-         "liver->intestine":"kB",
-         "liver->inorganicMercury":"kI",
-         "intestine->gut":"kR",
-         "intestine->inorganicMercury":"kD",
-         "intestine->feces":"kF",
-         "inorganicMercury->feces":"kIF"}},
-    "pcComments":"always related to outflow of organs", 
-    "partitionCoefficients":{
-       "kidney":"kidneyPC",
-       "richlyPerfused":"richlyPerfusedPC",
-       "fat":"fatPC",
-       "slowlyPerfused":"slowlyPerfusedPC",
-       "brainBlood":"brainBloodPC",
-       "liver":"liverPC",
-       "gut":"gutPC",
-       "brain->venous":"brainPC",
-       "hair->dump":"hairPC",
-       "redBloodCells->plasma":"rbcPC"}
-}

models/humanHG_withHairPC_parameters.json

@@ -1,223 +0,0 @@
-{"parameters":{
-        "bodyWeight":{"value":67.77,"units":"kg","dist":"lognormal","cv":0.26},
-        "bwPower0p75":{"derived":"bwPower0p75"},
-        "commentPC":"X",
-        "brainBloodPC":{"value":1,"dist":"lognormal","cv":0.3},
-        "brainPC":{"value":3,"dist":"lognormal","cv":0.3},
-        "fatPC":{"value":0.15,"dist":"lognormal","cv":0.3},
-        "gutPC":{"value":1,"dist":"lognormal","cv":0.7},
-        "hairPC":{"derived":"hairPC"},
-        "hairPCBlood":{"value":248.7,"dist":"lognormal","cv":0.7},
-        "kidneyPC":{"value":4.0,"dist":"lognormal","cv":0.3},
-        "liverPC":{"value":5.0,"dist":"lognormal","cv":0.3},
-        "rbcPC":{"value":12.0,"dist":"lognormal","cv":0.3},
-        "richlyPerfusedPC":{"value":1.0,"dist":"lognormal","cv":0.3},
-        "slowlyPerfusedPC":{"value":2.0,"dist":"lognormal","cv":0.3},
-        "commentCardiacOutput":"X",
-        "cardiacOutput":{"derived":"cardiacOutput"},
-        "cardiacOutputScaled":{"value":0.333,"unit":"l/min","dist":"normal","cv":0.22},
-        "commentFlows":"X",
-        "plasmaFlow":{"derived":"plasmaFlow"},
-        "kidneyFlow":{"derived":"kidneyFlow"},
-        "richlyPerfusedFlow":{"derived":"richlyPerfusedFlow"},
-        "fatFlow":{"derived":"fatFlow"},
-        "slowlyPerfusedFlow":{"derived":"slowlyPerfusedFlow"},
-        "brainBloodFlow":{"derived":"brainBloodFlow"},
-        "liverInFlow":{"derived":"liverInFlow"},
-        "liverOutFlow":{"derived":"liverOutFlow"},
-        "gutFlow":{"derived":"gutFlow"},
-        "commentFlowFraction":"X",
-        "plasmaFlowFraction":{"value":1},
-        "kidneyFlowFraction":{"value":0.175,"dist":"normal","cv":0.3},
-        "richlyPerfusedFlowFraction":{"value":0.183,"dist":"normal","cv":0.3},
-        "fatFlowFraction":{"value":0.052,"dist":"normal","cv":0.3},
-        "slowlyPerfusedFlowFraction":{"value":0.249,"dist":"normal","cv":0.3},
-        "brainBloodFlowFraction":{"value":0.114,"dist":"normal","cv":0.3},
-        "liverInFlowFraction":{"value":0.046,"dist":"normal","cv":0.32},
-        "commentLiverOutFlow":"sum of liver in and gut",
-        "liverOutFlowFraction":{"value":0.227,"dist":"normal","cv":0.3},
-        "gutFlowFraction":{"value":0.181,"dist":"normal","cv":0.33},
-        "commentVolumes":"X",
-        "plasmaVolume":{"derived":"plasmaVolume"},
-        "redBloodCellsVolume":{"derived":"redBloodCellsVolume"},
-        "kidneyVolume":{"derived":"kidneyVolume"},
-        "richlyPerfusedVolume":{"derived":"richlyPerfusedVolume"},
-        "fatVolume":{"derived":"fatVolume"},
-        "hairVolume":{"value":1e-3},
-        "slowlyPerfusedVolume":{"derived":"slowlyPerfusedVolume"},
-        "brainBloodVolume":{"derived":"brainBloodVolume"},
-        "brainVolume":{"derived":"brainVolume"},
-        "liverVolume":{"derived":"liverVolume"},
-        "gutVolume":{"derived":"gutVolume"},
-        "intestineVolume":{"derived":"intestineVolume"},
-        "commentFractions":"X",
-        "plasmaVolumeFraction":{"value":0.024,"dist":"normal","cv":0.14},
-        "redBloodCellsVolumeFraction":{"value":0.024,"dist":"normal","cv":0.25},
-        "kidneyVolumeFraction":{"value":0.004,"dist":"normal","cv":0.3},
-        "richlyPerfusedVolumeFraction":{"value":0.1,"dist":"normal","cv":0.3},
-        "fatVolumeFraction":{"value":0.273,"dist":"normal","cv":0.24},
-        "hairVolumeFraction":{"value":0.002,"dist":"normal","cv":0.5},
-        "slowlyPerfusedVolumeFraction":{"value":0.35,"dist":"normal","cv":0.16},
-        "brainBloodVolumeFraction":{"value":0.007,"dist":"normal","cv":0.3},
-        "brainVolumeFraction":{"value":0.02,"dist":"normal","cv":0.3},
-        "liverVolumeFraction":{"value":0.026,"dist":"normal","cv":0.25},
-        "gutVolumeFraction":{"value":0.017,"dist":"normal","cv":0.15},
-        "intestineVolumeFraction":{"value":0.14,"dist":"normal","cv":0.3},
-        "commentDiff":"X",
-        "kB":{"derived":"kB"},
-        "kBR":{"derived":"kBR"},
-        "kD":{"derived":"kD"},
-        "kF":{"derived":"kF"},
-        "kH":{"derived":"kH"},
-        "kI":{"derived":"kI"},
-        "kIF":{"derived":"kIF"},
-        "kRBC":{"derived":"kRBC"},
-        "kR":{"derived":"kR"},
-        "kU":{"derived":"kU"},
-        "commentDiffScaled":"X",
-        "kBScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kBRScaled":{"value":1.67e-4,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kDScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kFScaled":{"value":3.33e-6,"unit":"l/min","dist":"lognormal","cv":0.36},
-        "kHScaled":{"value":1.17e-7,"unit":"l/min","dist":"lognormal","cv":0.25},
-        "kIScaled":{"value":1.67e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kIFScaled":{"value":0,"unit":"l/min","noDist":"lognormal","cv":0.3},
-        "kRBCScaled":{"value":2.5e-2,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kRScaled":{"value":8.33e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kUScaled":{"value":0,"unit":"l/min"},
-        "zero":{"value":0},
-        "threeQuarters":{"value":0.75}},
-    "derivedParameters":{
-       "bwPower0p75":{
-          "type":"power",
-          "a":"bodyWeight",
-          "n":"threeQuarters"},
-       "cardiacOutput":{
-          "type":"product",
-          "a":"cardiacOutputScaled",
-          "b":"bwPower0p75"},
-        "plasmaFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"plasmaFlowFraction"},
-        "kidneyFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"kidneyFlowFraction"},
-        "richlyPerfusedFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"richlyPerfusedFlowFraction"},
-        "fatFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"fatFlowFraction"},
-        "slowlyPerfusedFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"slowlyPerfusedFlowFraction"},
-        "brainBloodFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"brainBloodFlowFraction"},
-        "liverInFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"liverInFlowFraction"},
-        "liverOutFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"liverOutFlowFraction"},
-        "gutFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"gutFlowFraction"},
-        "plasmaVolume":{
-           "type":"product",
-           "a":"plasmaVolumeFraction",
-           "b":"bodyWeight"},
-        "redBloodCellsVolume":{
-           "type":"product",
-           "a":"redBloodCellsVolumeFraction",
-           "b":"bodyWeight"},
-        "kidneyVolume":{
-           "type":"product",
-           "a":"kidneyVolumeFraction",
-           "b":"bodyWeight"},
-        "richlyPerfusedVolume":{
-           "type":"product",
-           "a":"richlyPerfusedVolumeFraction",
-           "b":"bodyWeight"},
-        "fatVolume":{
-           "type":"product",
-           "a":"fatVolumeFraction",
-           "b":"bodyWeight"},
-        "slowlyPerfusedVolume":{
-           "type":"product",
-           "a":"slowlyPerfusedVolumeFraction",
-           "b":"bodyWeight"},
-        "brainBloodVolume":{
-           "type":"product",
-           "a":"brainBloodVolumeFraction",
-           "b":"bodyWeight"},
-        "brainVolume":{
-           "type":"product",
-           "a":"brainVolumeFraction",
-           "b":"bodyWeight"},
-        "liverVolume":{
-           "type":"product",
-           "a":"liverVolumeFraction",
-           "b":"bodyWeight"},
-        "gutVolume":{
-           "type":"product",
-           "a":"gutVolumeFraction",
-           "b":"bodyWeight"},
-        "intestineVolume":{
-           "type":"product",
-           "a":"intestineVolumeFraction",
-           "b":"bodyWeight"},
-       "hairPC":{
-          "type":"ratio",
-          "a":"hairPCBlood",
-          "b":"slowlyPerfusedPC"},
-       "kB":{
-          "type":"product",
-          "a":"kBScaled",
-          "b":"bwPower0p75"},
-       "kBR":{
-          "type":"product",
-          "a":"kBRScaled",
-          "b":"bwPower0p75"},
-       "kD":{
-          "type":"product",
-          "a":"kDScaled",
-          "b":"bwPower0p75"},
-       "kF":{
-          "type":"product",
-          "a":"kFScaled",
-          "b":"bwPower0p75"},
-       "kH":{
-          "type":"product",
-          "a":"kHScaled",
-          "b":"bwPower0p75"},
-       "kI":{
-          "type":"product",
-          "a":"kIScaled",
-          "b":"bwPower0p75"},
-       "kIF":{
-          "type":"product",
-          "a":"kIFScaled",
-          "b":"bwPower0p75"},
-       "kRBC":{
-          "type":"product",
-          "a":"kRBCScaled",
-          "b":"bwPower0p75"},
-       "kR":{
-          "type":"product",
-          "a":"kRScaled",
-          "b":"bwPower0p75"},
-       "kU":{
-          "type":"product",
-          "a":"kUScaled",
-          "b":"bwPower0p75"}}
-}

models/humanHGplusI.json

@@ -1,86 +0,0 @@
-{
-   "timeUnit":"min",
-   "compartments":[
-      "redBloodCells","plasma","venous","kidney","urine",
-      "richlyPerfused","fat","slowlyPerfused","hair",
-      "brainBlood","brain",
-      "liver","gut","intestine","feces",
-      "plasmaI","liverI","kidneyI","hairI","brainI","fecesI"],
-   "commentScaled":"add compartments that only have inputs so they can be scaled to total input",
-   "scaled":["hair","hairI","feces","fecesI","urine"],
-   "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
-   "volumeComment":"in a compartment w/o volume, value is mass",
-   "volumes":{
-      "plasma":"plasmaVolume",
-      "venous":"venousVolume",
-      "kidney":"kidneyVolume",
-      "richlyPerfused":"richlyPerfusedVolume",
-      "fat":"fatVolume",
-      "slowlyPerfused":"slowlyPerfusedVolume",
-      "brainBlood":"brainBloodVolume",
-      "gut":"gutVolume",
-      "intestine":"intestineVolume",
-      "redBloodCells":"redBloodCellsVolume",
-      "brain":"brainVolume",
-      "liver":"liverVolume",
-      "plasmaI":"plasmaVolume",
-      "liverI":"liverVolume",
-      "kidneyI":"kidneyVolume",
-      "brainI":"brainVolume"
-      },
-   "flows":{
-      "(plasma,venous):kidney":"kidneyFlow",
-      "(plasma,venous):richlyPerfused":"richlyPerfusedFlow",
-      "(plasma,venous):fat":"fatFlow",
-      "(plasma,venous):slowlyPerfused":"slowlyPerfusedFlow",
-      "(plasma,venous):brainBlood":"brainBloodFlow",
-      "plasma:liver":"liverInFlow",
-      "liver:venous":"liverOutFlow",
-      "(plasma,liver):gut":"gutFlow",
-      "plasma:venous":"plasmaFlow"},
-   "commentSources":"constants in concentration units per s",
-   "commentHeavyside":"value is mass of exogene/volume of container/duration",
-   "inputs":{
-      "intestine":"oralIngestion"},
-   "commentBindings":"split to flow and diffusion dominated",
-   "bindings": {
-      "flowComments":"group common sources or targets with brackets",
-      "flow":[
-         "(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,liver)->venous",
-         "gut->liver",
-         "plasma->(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,liver,gut)",
-         "venous->plasma"],
-      "diffusion":{
-         "plasma->redBloodCells":"kRBC",
-         "redBloodCells->plasma":"kRBC",
-         "kidney->urine":"kU",
-         "slowlyPerfused->hair":"kH",
-         "brainBlood->brain":"kBR",
-         "brain->venous":"kBR",
-         "liver->intestine":"kB",
-         "intestine->gut":"kR",
-         "intestine->feces":"kF",
-         "plasma->liverI":"dBL",
-         "liverI->plasmaI":"kLB:I",
-         "liverI->fecesI":"kLF:I",
-         "plasmaI->kidneyI":"kBK:I",
-         "kidneyI->plasmaI":"kKB:I",
-         "kidneyI->urine":"kKU:I",
-         "plasmaI->hairI":"kBH:I",
-         "brainI->plasmaI":"kBrB:I",
-         "plasmaI->urine":"kBU:I",
-         "plasmaI->brainI":"kBBr:I",
-         "plasmaI->fecesI":"kBF:I",
-         "plasma->brainI":"dBBr"}},
-    "pcComments":"always related to outflow of organs", 
-    "partitionCoefficients":{
-       "kidney":"kidneyPC",
-       "richlyPerfused":"richlyPerfusedPC",
-       "fat":"fatPC",
-       "slowlyPerfused":"slowlyPerfusedPC",
-       "brainBlood":"brainBloodPC",
-       "liver":"liverPC",
-       "gut":"gutPC",
-       "brain->venous":"brainPC",
-       "redBloodCells->plasma":"rbcPC"}
-}

models/humanHGplusI_RBC.json

@@ -1,86 +0,0 @@
-{
-   "timeUnit":"min",
-   "compartments":[
-      "redBloodCells","plasma","venous","kidney","urine",
-      "richlyPerfused","fat","slowlyPerfused","hair",
-      "brainBlood","brain",
-      "liver","gut","intestine","feces",
-      "bloodI","liverI","kidneyI","hairI","brainI","fecesI"],
-   "commentScaled":"add compartments that only have inputs so they can be scaled to total input",
-   "scaled":["hair","hairI","feces","fecesI","urine"],
-   "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
-   "volumeComment":"in a compartment w/o volume, value is mass",
-   "volumes":{
-      "plasma":"plasmaVolume",
-      "venous":"venousVolume",
-      "kidney":"kidneyVolume",
-      "richlyPerfused":"richlyPerfusedVolume",
-      "fat":"fatVolume",
-      "slowlyPerfused":"slowlyPerfusedVolume",
-      "brainBlood":"brainBloodVolume",
-      "gut":"gutVolume",
-      "intestine":"intestineVolume",
-      "redBloodCells":"redBloodCellsVolume",
-      "brain":"brainVolume",
-      "liver":"liverVolume",
-      "bloodI":"bloodVolume",
-      "liverI":"liverVolume",
-      "kidneyI":"kidneyVolume",
-      "brainI":"brainVolume"
-      },
-   "flows":{
-      "(plasma,venous):kidney":"kidneyFlow",
-      "(plasma,venous):richlyPerfused":"richlyPerfusedFlow",
-      "(plasma,venous):fat":"fatFlow",
-      "(plasma,venous):slowlyPerfused":"slowlyPerfusedFlow",
-      "(plasma,venous):brainBlood":"brainBloodFlow",
-      "plasma:liver":"liverInFlow",
-      "liver:venous":"liverOutFlow",
-      "(plasma,liver):gut":"gutFlow",
-      "plasma:venous":"plasmaFlow"},
-   "commentSources":"constants in concentration units per s",
-   "commentHeavyside":"value is mass of exogene/volume of container/duration",
-   "inputs":{
-      "intestine":"oralIngestion"},
-   "commentBindings":"split to flow and diffusion dominated",
-   "bindings": {
-      "flowComments":"group common sources or targets with brackets",
-      "flow":[
-         "(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,liver)->venous",
-         "gut->liver",
-         "plasma->(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,liver,gut)",
-         "venous->plasma"],
-      "diffusion":{
-         "plasma->redBloodCells":"kRBC",
-         "redBloodCells->plasma":"kRBC",
-         "kidney->urine":"kU",
-         "slowlyPerfused->hair":"kH",
-         "brainBlood->brain":"kBR",
-         "brain->venous":"kBR",
-         "liver->intestine":"kB",
-         "intestine->gut":"kR",
-         "intestine->feces":"kF",
-         "plasma->liverI":"dBLPlasma",
-         "liverI->bloodI":"kLB:I",
-         "liverI->fecesI":"kLF:I",
-         "bloodI->kidneyI":"kBK:I",
-         "kidneyI->bloodI":"kKB:I",
-         "kidneyI->urine":"kKU:I",
-         "bloodI->hairI":"kBH:I",
-         "brainI->bloodI":"kBrB:I",
-         "bloodI->urine":"kBU:I",
-         "bloodI->brainI":"kBBr:I",
-         "bloodI->fecesI":"kBF:I",
-         "plasma->brainI":"dBBrPlasma"}},
-    "pcComments":"always related to outflow of organs", 
-    "partitionCoefficients":{
-        "kidney":"kidneyPCplasma",
-        "richlyPerfused":"richlyPerfusedPCplasma",
-        "fat":"fatPCplasma",
-        "slowlyPerfused":"slowlyPerfusedPCplasma",
-        "brainBlood":"brainBloodPCplasma",
-        "liver":"liverPCplasma",
-        "gut":"gutPCplasma",
-        "brain->venous":"brainPCplasma",
-        "redBloodCells->plasma":"rbcPCplasma"}
-}

models/humanHGplusI_RBC_parameters.json

@@ -1,390 +0,0 @@
-{"parameters":{
-    "bodyWeight":{"value":67.77,"units":"kg","dist":"lognormal","cv":0.26},
-    "bwPower0p75":{"derived":"bwPower0p75"},
-    "commentInputs":"X",
-    "oralIngestion":{"value":0.0486,"unit":"ug/min"},
-    "commentPC":"X",
-    "bloodToPlasmaPCscale":{"derived":"bloodToPlasmaPCscale"},
-    "rbcPCfraction":{"derived":"rbcPCfraction"},
-    "brainBloodPCplasma":{"value":1,"dist":"lognormal","cv":0.3},
-    "brainPCblood":{"value":3,"dist":"lognormal","cv":0.3},
-    "fatPCblood":{"value":0.15,"dist":"lognormal","cv":0.3},
-    "gutPCblood":{"value":1,"dist":"lognormal","cv":0.7},
-    "kidneyPCblood":{"value":4.0,"dist":"lognormal","cv":0.3},
-    "liverPCblood":{"value":5.0,"dist":"lognormal","cv":0.3},
-    "rbcPCplasma":{"value":12.0,"dist":"lognormal","cv":0.3},
-    "richlyPerfusedPCblood":{"value":1.0,"dist":"lognormal","cv":0.3},
-    "slowlyPerfusedPCblood":{"value":2.0,"dist":"lognormal","cv":0.3},
-    "commentPCplasma":"X",
-    "brainPCplasma":{"derived":"brainPCplasma"},
-    "fatPCplasma":{"derived":"fatPCplasma"},
-    "gutPCplasma":{"derived":"gutPCplasma"},
-    "kidneyPCplasma":{"derived":"kidneyPCplasma"},
-    "liverPCplasma":{"derived":"liverPCplasma"},
-    "richlyPerfusedPCplasma":{"derived":"richlyPerfusedPCplasma"},
-    "slowlyPerfusedPCplasma":{"derived":"slowlyPerfusedPCplasma"},
-    "commentCardiacOutput":"X",
-    "cardiacOutput":{"derived":"cardiacOutput"},
-    "cardiacOutputScaled":{"value":0.333,"unit":"l/min","dist":"normal","cv":0.22},
-    "commentFlows":"X",
-    "plasmaFlow":{"derived":"plasmaFlow"},
-    "kidneyFlow":{"derived":"kidneyFlow"},
-    "richlyPerfusedFlow":{"derived":"richlyPerfusedFlow"},
-    "fatFlow":{"derived":"fatFlow"},
-    "slowlyPerfusedFlow":{"derived":"slowlyPerfusedFlow"},
-    "brainBloodFlow":{"derived":"brainBloodFlow"},
-    "liverInFlow":{"derived":"liverInFlow"},
-    "liverOutFlow":{"derived":"liverOutFlow"},
-    "gutFlow":{"derived":"gutFlow"},
-    "commentFlowFraction":"X",
-    "plasmaFlowFraction":{"value":1},
-    "kidneyFlowFraction":{"value":0.175,"dist":"normal","cv":0.3},
-    "richlyPerfusedFlowFraction":{"value":0.183,"dist":"normal","cv":0.3},
-    "fatFlowFraction":{"value":0.052,"dist":"normal","cv":0.3},
-    "slowlyPerfusedFlowFraction":{"value":0.249,"dist":"normal","cv":0.3},
-    "brainBloodFlowFraction":{"value":0.114,"dist":"normal","cv":0.3},
-    "liverInFlowFraction":{"value":0.046,"dist":"normal","cv":0.32},
-    "commentLiverOutFlow":"sum of liver in and gut",
-    "liverOutFlowFraction":{"value":0.227,"dist":"normal","cv":0.3},
-    "gutFlowFraction":{"value":0.181,"dist":"normal","cv":0.33},
-    "commentVolumes":"X",
-    "plasmaVolume":{"derived":"plasmaVolume"},
-    "venousVolume":{"derived":"venousVolume"},
-    "redBloodCellsVolume":{"derived":"redBloodCellsVolume"},
-    "bloodVolume":{"derived":"bloodVolume"},
-    "kidneyVolume":{"derived":"kidneyVolume"},
-    "richlyPerfusedVolume":{"derived":"richlyPerfusedVolume"},
-    "fatVolume":{"derived":"fatVolume"},
-    "slowlyPerfusedVolume":{"derived":"slowlyPerfusedVolume"},
-    "brainBloodVolume":{"derived":"brainBloodVolume"},
-    "brainVolume":{"derived":"brainVolume"},
-    "liverVolume":{"derived":"liverVolume"},
-    "gutVolume":{"derived":"gutVolume"},
-    "intestineVolume":{"derived":"intestineVolume"},
-    "commentFractionsDerived":"X",
-    "plasmaVolumeFractionBlood":{"derived":"plasmaVolumeFractionBlood"},
-    "rbcVolumeFractionBlood":{"derived":"rbcVolumeFractionBlood"},
-    "bloodVolumeFraction":{"derived":"bloodVolumeFraction"},
-    "venousVolumeFraction":{"derived":"venousVolumeFraction"},
-    "plasmaVolumeFraction":{"derived":"plasmaVolumeFraction"},
-    "commentFractions":"X",
-    "plasmaTotalVolumeFraction":{"value":0.04,"dist":"normal","cv":0.14},
-    "redBloodCellsVolumeFraction":{"value":0.024,"dist":"normal","cv":0.25},
-    "kidneyVolumeFraction":{"value":0.004,"dist":"normal","cv":0.3},
-    "richlyPerfusedVolumeFraction":{"value":0.1,"dist":"normal","cv":0.3},
-    "fatVolumeFraction":{"value":0.273,"dist":"normal","cv":0.24},
-    "hairVolumeFraction":{"value":0.002,"dist":"normal","cv":0.5},
-    "slowlyPerfusedVolumeFraction":{"value":0.35,"dist":"normal","cv":0.16},
-    "brainBloodVolumeFraction":{"value":0.007,"dist":"normal","cv":0.3},
-    "brainVolumeFraction":{"value":0.02,"dist":"normal","cv":0.3},
-    "liverVolumeFraction":{"value":0.026,"dist":"normal","cv":0.25},
-    "gutVolumeFraction":{"value":0.017,"dist":"normal","cv":0.15},
-    "intestineVolumeFraction":{"value":0.014,"dist":"normal","cv":0.3},
-    "commentDiff":"X",
-    "kB":{"derived":"kB"},
-    "kBR":{"derived":"kBR"},
-    "kD":{"derived":"kD"},
-    "kF":{"derived":"kF"},
-    "kH":{"derived":"kH"},
-    "kHOriginal":{"derived":"kHOriginal"},
-    "kI":{"derived":"kI"},
-    "kIF":{"derived":"kIF"},
-    "kRBC":{"derived":"kRBC"},
-    "kR":{"derived":"kR"},
-    "kU":{"derived":"kU"},
-    "commentInorganicMercury":"X",
-    "dBLPlasma":{"derived":"dBLPlasma"},
-    "dBBrPlasma":{"derived":"dBBrPlasma"},
-    "dBL":{"derived":"dBL"},
-    "dBBr":{"derived":"dBBr"},
-    "kLB:I":{"derived":"kLB:I"},
-    "kBK:I":{"derived":"kBK:I"},
-    "kKB:I":{"derived":"kKB:I"},
-    "kKU:I":{"derived":"kKU:I"},
-    "kBH:I":{"derived":"kBH:I"},
-    "kBU:I":{"derived":"kBU:I"},
-    "kBF:I":{"derived":"kBF:I"},
-    "kLF:I":{"derived":"kLF:I"},
-    "kBBr:I":{"derived":"kBBr:I"},
-    "kBrB:I":{"derived":"kBrB:I"},
-    "commentDiffScaled":"X",
-    "kBScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
-    "kBRScaled":{"value":1.67e-4,"unit":"l/min","dist":"lognormal","cv":0.3},
-    "kDScaled":{"value":1e-4,"unit":"l/hour","dist":"lognormal","cv":0.3},
-    "kFScaled":{"value":2e-4,"unit":"l/hour","dist":"lognormal","cv":0.36},
-    "kHScaled":{"value":7e-6,"unit":"l/hour","dist":"lognormal","cv":0.25},
-    "kIScaled":{"value":1e-5,"unit":"l/hour","dist":"lognormal","cv":0.3},
-    "kIFScaled":{"value":0,"unit":"l/min","noDist":"lognormal","cv":0.3},
-    "kRBCScaled":{"value":2.5e-2,"unit":"l/min","dist":"lognormal","cv":0.3},
-    "kRScaled":{"value":8.33e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
-    "kUScaled":{"value":0,"unit":"l/min"},
-    "commentInorganicMerucryFromPaper":"X",
-    "dBLPaper":{"value":0.175,"unit":"/day","dist":"lognormal","cv":0.3},
-    "dBBrPaper":{"value":0.0,"unit":"/day","noDist":"lognormal","cv":0.3},
-    "kLB:IPaper":{"value":0.894,"unit":"/day","dist":"lognormal","cv":0.3},
-    "kBK:IPaper":{"value":17.1234,"unit":"/day","dist":"lognormal","cv":0.3},
-    "kKB:IPaper":{"value":0.001,"unit":"/day","dist":"lognormal","cv":0.3},
-    "kKU:IPaper":{"value":0.006949,"unit":"/day","dist":"lognormal","cv":0.3},
-    "kBH:IPaper":{"value":0.14,"unit":"/day","dist":"lognormal","cv":0.3},
-    "kBU:IPaper":{"value":0.006994,"unit":"/day","dist":"lognormal","cv":0.3},
-    "kBF:IPaper":{"value":3.9917,"unit":"/day","dist":"lognormal","cv":0.3},
-    "kLF:IPaper":{"value":1.5476,"unit":"/day","dist":"lognormal","cv":0.3},
-    "kBBr:IPaper":{"value":0.0028,"unit":"/day","dist":"lognormal","cv":0.3},
-    "kBrB:IPaper":{"value":0.052,"unit":"/day","dist":"lognormal","cv":0.3},
-    "zero":{"value":0},
-    "threeQuarters":{"value":0.75},
-    "kHCorrection":{"value":1.67}},
-"derivedParameters":{
-    "bwPower0p75":{
-        "type":"power",
-        "a":"bodyWeight",
-        "n":"threeQuarters"},
-    "cardiacOutput":{
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-        "a":"cardiacOutputScaled",
-        "b":"bwPower0p75"},
-    "plasmaFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"plasmaFlowFraction"},
-    "kidneyFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"kidneyFlowFraction"},
-    "richlyPerfusedFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"richlyPerfusedFlowFraction"},
-    "fatFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"fatFlowFraction"},
-    "slowlyPerfusedFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"slowlyPerfusedFlowFraction"},
-    "brainBloodFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"brainBloodFlowFraction"},
-    "liverInFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"liverInFlowFraction"},
-    "liverOutFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"liverOutFlowFraction"},
-    "gutFlow":{
-        "type":"product",
-        "a":"cardiacOutput",
-        "b":"gutFlowFraction"},
-    "bloodToPlasmaPCscale":{
-        "type":"sum",
-        "a":"plasmaVolumeFractionBlood",
-        "b":"rbcPCfraction"},
-    "rbcPCfraction":{
-        "type":"product",
-        "a":"rbcVolumeFractionBlood",
-        "b":"rbcPCplasma"},
-    "brainPCplasma":{
-        "type":"product",
-        "a":"brainPCblood",
-        "b":"bloodToPlasmaPCscale"},
-    "kidneyPCplasma":{
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-        "a":"kidneyPCblood",
-        "b":"bloodToPlasmaPCscale"},
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-        "a":"richlyPerfusedPCblood",
-        "b":"bloodToPlasmaPCscale"},
-    "slowlyPerfusedPCplasma":{
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-        "a":"slowlyPerfusedPCblood",
-        "b":"bloodToPlasmaPCscale"},
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-        "b":"bloodToPlasmaPCscale"},
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-        "b":"bloodToPlasmaPCscale"},
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-        "b":"bodyWeight"},
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-        "b":"bodyWeight"},
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-        "a":"redBloodCellsVolumeFraction",
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-        "b":"redBloodCellsVolumeFraction"}, 
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-        "b":"bloodToPlasmaPCscale"},
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-        "a":"dBBrPaper",
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-    "dBBrPlasma":{
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-        "a":"dBBr",
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-        "b":"bloodVolume"},
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-    "kKU:I":{
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-        "type":"product",
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-    "kLF:I":{
-        "type":"product",
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-        "b":"bloodVolume"},
-    "kBrB:I":{
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-        "a":"kBrB:IPaper",
-        "b":"brainVolume"}}
-}

models/humanHGplusI_parameters.json

@@ -1,298 +0,0 @@
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-        "kidneyFlow":{"derived":"kidneyFlow"},
-        "richlyPerfusedFlow":{"derived":"richlyPerfusedFlow"},
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-        "slowlyPerfusedFlow":{"derived":"slowlyPerfusedFlow"},
-        "brainBloodFlow":{"derived":"brainBloodFlow"},
-        "liverInFlow":{"derived":"liverInFlow"},
-        "liverOutFlow":{"derived":"liverOutFlow"},
-        "gutFlow":{"derived":"gutFlow"},
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-        "venousVolume":{"derived":"venousVolume"},
-        "redBloodCellsVolume":{"derived":"redBloodCellsVolume"},
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-        "brainBloodVolume":{"derived":"brainBloodVolume"},
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-        "liverVolume":{"derived":"liverVolume"},
-        "gutVolume":{"derived":"gutVolume"},
-        "intestineVolume":{"derived":"intestineVolume"},
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-        "gutVolumeFraction":{"value":0.017,"dist":"normal","cv":0.15},
-        "intestineVolumeFraction":{"value":0.014,"dist":"normal","cv":0.3},
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-        "kBR":{"derived":"kBR"},
-        "kD":{"derived":"kD"},
-        "kF":{"derived":"kF"},
-        "kH":{"derived":"kH"},
-        "kI":{"derived":"kI"},
-        "kIF":{"derived":"kIF"},
-        "kRBC":{"derived":"kRBC"},
-        "kR":{"derived":"kR"},
-        "kU":{"derived":"kU"},
-        "commentInorganicMercury":"X",
-        "dBL":{"derived":"dBL"},
-        "dBBr":{"derived":"dBBr"},
-        "kLB:I":{"derived":"kLB:I"},
-        "kBK:I":{"derived":"kBK:I"},
-        "kKB:I":{"derived":"kKB:I"},
-        "kKU:I":{"derived":"kKU:I"},
-        "kBH:I":{"derived":"kBH:I"},
-        "kBU:I":{"derived":"kBU:I"},
-        "kBF:I":{"derived":"kBF:I"},
-        "kLF:I":{"derived":"kLF:I"},
-        "kBBr:I":{"derived":"kBBr:I"},
-        "kBrB:I":{"derived":"kBrB:I"},
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-        "kRBCScaled":{"value":2.5e-2,"unit":"l/min","dist":"lognormal","cv":0.3},
-        "kRScaled":{"value":8.33e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
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-        "kBK:IPaper":{"value":17.1234,"unit":"/day","dist":"lognormal","cv":0.3},
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-          "n":"threeQuarters"},
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-          "a":"cardiacOutputScaled",
-          "b":"bwPower0p75"},
-        "plasmaFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"plasmaFlowFraction"},
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-           "a":"cardiacOutput",
-           "b":"kidneyFlowFraction"},
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-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"richlyPerfusedFlowFraction"},
-        "fatFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"fatFlowFraction"},
-        "slowlyPerfusedFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"slowlyPerfusedFlowFraction"},
-        "brainBloodFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"brainBloodFlowFraction"},
-        "liverInFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"liverInFlowFraction"},
-        "liverOutFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"liverOutFlowFraction"},
-        "gutFlow":{
-           "type":"product",
-           "a":"cardiacOutput",
-           "b":"gutFlowFraction"},
-        "plasmaVolume":{
-           "type":"product",
-           "a":"plasmaVolumeFraction",
-           "b":"bodyWeight"},
-        "venousVolume":{
-           "type":"product",
-           "a":"venousVolumeFraction",
-           "b":"bodyWeight"},
-        "redBloodCellsVolume":{
-           "type":"product",
-           "a":"redBloodCellsVolumeFraction",
-           "b":"bodyWeight"},
-        "kidneyVolume":{
-           "type":"product",
-           "a":"kidneyVolumeFraction",
-           "b":"bodyWeight"},
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-           "type":"product",
-           "a":"richlyPerfusedVolumeFraction",
-           "b":"bodyWeight"},
-        "fatVolume":{
-           "type":"product",
-           "a":"fatVolumeFraction",
-           "b":"bodyWeight"},
-        "slowlyPerfusedVolume":{
-           "type":"product",
-           "a":"slowlyPerfusedVolumeFraction",
-           "b":"bodyWeight"},
-        "brainBloodVolume":{
-           "type":"product",
-           "a":"brainBloodVolumeFraction",
-           "b":"bodyWeight"},
-        "brainVolume":{
-           "type":"product",
-           "a":"brainVolumeFraction",
-           "b":"bodyWeight"},
-        "liverVolume":{
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-           "a":"liverVolumeFraction",
-           "b":"bodyWeight"},
-        "gutVolume":{
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-           "a":"gutVolumeFraction",
-           "b":"bodyWeight"},
-        "intestineVolume":{
-           "type":"product",
-           "a":"intestineVolumeFraction",
-           "b":"bodyWeight"},
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-          "a":"kBScaled",
-          "b":"bwPower0p75"},
-       "kBR":{
-          "type":"product",
-          "a":"kBRScaled",
-          "b":"bwPower0p75"},
-       "kD":{
-          "type":"product",
-          "a":"kDScaled",
-          "b":"bwPower0p75"},
-       "kF":{
-          "type":"product",
-          "a":"kFScaled",
-          "b":"bwPower0p75"},
-       "kH":{
-          "type":"product",
-          "a":"kHScaled",
-          "b":"bwPower0p75"},
-       "kI":{
-          "type":"product",
-          "a":"kIScaled",
-          "b":"bwPower0p75"},
-       "kIF":{
-          "type":"product",
-          "a":"kIFScaled",
-          "b":"bwPower0p75"},
-       "kRBC":{
-          "type":"product",
-          "a":"kRBCScaled",
-          "b":"bwPower0p75"},
-       "kR":{
-          "type":"product",
-          "a":"kRScaled",
-          "b":"bwPower0p75"},
-       "kU":{
-          "type":"product",
-          "a":"kUScaled",
-          "b":"bwPower0p75"},
-       "dBL":{
-          "type":"product",
-          "a":"dBLPaper",
-          "b":"plasmaVolume"},
-       "dBBr":{
-          "type":"product",
-          "a":"dBBrPaper",
-          "b":"plasmaVolume"},
-       "kLB:I":{
-          "type":"product",
-          "a":"kLB:IPaper",
-          "b":"liverVolume"},
-       "kBK:I":{
-          "type":"product",
-          "a":"kBK:IPaper",
-          "b":"plasmaVolume"},
-       "kKB:I":{
-          "type":"product",
-          "a":"kKB:IPaper",
-          "b":"kidneyVolume"},
-       "kKU:I":{
-          "type":"product",
-          "a":"kKU:IPaper",
-          "b":"kidneyVolume"},
-       "kBH:I":{
-          "type":"product",
-          "a":"kBH:IPaper",
-          "b":"plasmaVolume"},
-       "kBU:I":{
-          "type":"product",
-          "a":"kBU:IPaper",
-          "b":"plasmaVolume"},
-       "kBF:I":{
-          "type":"product",
-          "a":"kBF:IPaper",
-          "b":"plasmaVolume"},
-       "kLF:I":{
-          "type":"product",
-          "a":"kLF:IPaper",
-          "b":"liverVolume"},
-       "kBBr:I":{
-          "type":"product",
-          "a":"kBBr:IPaper",
-          "b":"plasmaVolume"},
-       "kBrB:I":{
-          "type":"product",
-          "a":"kBrB:IPaper",
-          "b":"brainVolume"}}
-}