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@@ -0,0 +1,109 @@
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+{
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+ "compartments":["adipose","brain","heart","kidney","liver",
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+ "splanchnic","stomach","muscle","skin","testes","remainder","lung",
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+ "excrement","arterial","venous","source"],
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+ "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
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+ "volumes":{
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+ "adipose":"adiposeVolume",
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+ "brain":"brainVolume",
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+ "heart":"heartVolume",
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+ "kidney":"kidneyVolume",
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+ "liver":"liverVolume",
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+ "lung":"lungVolume",
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+ "muscle":"muscleVolume",
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+ "skin":"skinVolume",
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+ "splanchnic":"splanchnicVolume",
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+ "stomach":"stomachVolume",
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+ "testes":"testesVolume",
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+ "remainder":"remainderVolume",
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+ "venous":"venousVolume",
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+ "arterial":"arterialVolume"},
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+ "flows":{
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+ "(arterial,venous):adipose":"adiposeFlow",
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+ "(arterial,venous):brain":"brainFlow",
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+ "(arterial,venous):heart":"heartFlow",
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+ "(arterial,venous):kidney":"kidneyFlow",
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+ "arterial:liver":"liverInFlow",
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+ "liver:venous":"liverOutFlow",
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+ "(arterial,venous):lung":"totalFlow",
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+ "(arterial,venous):muscle":"muscleFlow",
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+ "(arterial,venous):skin":"skinFlow",
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+ "(arterial,liver):splanchnic":"splanchnicFlow",
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+ "(arterial,liver):stomach":"stomachFlow",
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+ "(arterial,venous):testes":"testesFlow",
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+ "(arterial,venous):remainder":"remainderFlow"},
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+ "commentSources":"constants in concentration units per s",
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+ "sources":{
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+ "arterial":{"name":"exponential","k":-0.005,"constant":0},
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+ "venous":{"name":"Heavyside","limit":300,"value":0.61e2}},
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+ "commentBindings":"split to flow and diffusion dominated",
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+ "bindings": {
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+ "flowComments":"group common sources or targets with brackets",
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+ "flow":[
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+ "(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder)->venous",
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+ "(splanchnic,stomach)->liver",
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+ "arterial->(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder,splanchnic,stomach)",
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+ "venous->lung",
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+ "lung->arterial"],
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+ "diffusion":{
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+ "liver->excrement":"k1"}},
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+ "pcComments":"always related to outflow of organs",
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+ "partitionCoefficients":{
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+ "adipose":"adiposePC",
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+ "brain":"brainPC",
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+ "heart":"heartPC",
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+ "kidney":"kidneyPC",
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+ "liver":"liverPC",
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+ "lung":"lungPC",
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+ "muscle":"musclePC",
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+ "remainder":"remainderPC",
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+ "skin":"skinPC",
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+ "splanchnic":"splanchnicPC",
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+ "stomach":"stomachPC",
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+ "testes":"testesPC"},
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+ "parameters":{
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+ "adiposePC":{"value":23.1,"dist":"lognormal","cv":0.3},
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+ "brainPC":{"value":2.2,"dist":"lognormal","cv":0.3},
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+ "heartPC":{"value":4.3},
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+ "kidneyPC":{"value":5.2},
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+ "liverPC":{"value":9.1},
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+ "lungPC":{"value":5.3},
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+ "musclePC":{"value":2.4},
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+ "remainderPC":{"value":16.5},
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+ "skinPC":{"value":3.2,"dist":"lognormal","cv":0.3},
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+ "splanchnicPC":{"value":4.3},
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+ "stomachPC":{"value":4.5},
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+ "testesPC":{"value":4.7},
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+ "flowNotes":"liverOutFlow is sum of liver,splanchnic and stomach",
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+ "flowNotes1":"liverOutFlow=3.55+20.25+1.9",
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+ "adiposeFlow":{"value":2.55,"unit":"ml/min"},
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+ "brainFlow":{"value":0.78,"unit":"ml/min"},
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+ "heartFlow":{"value":4.2,"unit":"ml/min"},
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+ "kidneyFlow":{"value":16.61,"unit":"ml/min"},
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+ "liverInFlow":{"value":3.55,"unit":"ml/min"},
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+ "liverOutFlow":{"value":25.7,"unit":"ml/min"},
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+ "totalFlow":{"value":80,"unit":"ml/min"},
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+ "muscleFlow":{"value":16.25,"unit":"ml/min"},
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+ "skinFlow":{"value":7.1,"unit":"ml/min"},
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+ "splanchnicFlow":{"value":20.25,"unit":"ml/min"},
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+ "stomachFlow":{"value":1.9,"unit":"ml/min"},
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+ "testesFlow":{"value":1.9,"unit":"ml/min"},
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+ "remainderFlow":{"value":4.91,"unit":"ml/min"},
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+ "adiposeVolume":{"value":10,"unit":"g"},
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+ "brainVolume":{"value":1.2,"unit":"g"},
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+ "heartVolume":{"value":1,"unit":"g"},
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+ "kidneyVolume":{"value":2,"unit":"g"},
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+ "liverVolume":{"value":11,"unit":"g"},
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+ "lungVolume":{"value":1.2,"unit":"g"},
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+ "muscleVolume":{"value":125,"unit":"g"},
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+ "skinVolume":{"value":43.8,"unit":"g"},
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+ "splanchnicVolume":{"value":15,"unit":"g"},
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+ "stomachVolume":{"value":1.1,"unit":"g"},
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+ "testesVolume":{"value":2.5,"unit":"g"},
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+ "remainderVolume":{"value":15.8,"unit":"g"},
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+ "venousVolume":{"value":13.6,"unit":"g"},
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+ "arterialVolume":{"value":6.8,"unit":"g"},
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+ "liverToExcrementNotes":"CL=422 ml/min,PC=9.1,f=0.15,V=11g->k1=0.0105/s",
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+ "k1":{"value":0.0105,"unit":"1/s"}}
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+
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+}
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