{ "compartments":["adipose","brain","heart","kidney","liver", "splanchnic","stomach","muscle","skin","testes","remainder","lung", "excrement","arterial","venous","source"], "commentParameters":"every parameter must have a value, name is optional and used in SE computation", "volumes":{ "adipose":"adiposeVolume", "brain":"brainVolume", "heart":"heartVolume", "kidney":"kidneyVolume", "liver":"liverVolume", "lung":"lungVolume", "muscle":"muscleVolume", "skin":"skinVolume", "splanchnic":"splanchnicVolume", "stomach":"stomachVolume", "testes":"testesVolume", "remainder":"remainderVolume", "venous":"venousVolume", "arterial":"arterialVolume"}, "flows":{ "(arterial,venous):adipose":"adiposeFlow", "(arterial,venous):brain":"brainFlow", "(arterial,venous):heart":"heartFlow", "(arterial,venous):kidney":"kidneyFlow", "arterial:liver":"liverInFlow", "liver:venous":"liverOutFlow", "(arterial,venous):lung":"totalFlow", "(arterial,venous):muscle":"muscleFlow", "(arterial,venous):skin":"skinFlow", "(arterial,liver):splanchnic":"splanchnicFlow", "(arterial,liver):stomach":"stomachFlow", "(arterial,venous):testes":"testesFlow", "(arterial,venous):remainder":"remainderFlow"}, "commentSources":"constants in concentration units per s", "sources":{ "arterial":{"name":"exponential","k":-0.005,"constant":0}, "venous":{"name":"Heavyside","limit":300,"value":0.61e2}}, "commentBindings":"split to flow and diffusion dominated", "bindings": { "flowComments":"group common sources or targets with brackets", "flow":[ "(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder)->venous", "(splanchnic,stomach)->liver", "arterial->(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder,splanchnic,stomach)", "venous->lung", "lung->arterial"], "diffusion":{ "liver->excrement":"k1"}}, "pcComments":"always related to outflow of organs", "partitionCoefficients":{ "adipose":"adiposePC", "brain":"brainPC", "heart":"heartPC", "kidney":"kidneyPC", "liver":"liverPC", "lung":"lungPC", "muscle":"musclePC", "remainder":"remainderPC", "skin":"skinPC", "splanchnic":"splanchnicPC", "stomach":"stomachPC", "testes":"testesPC"}, "parameters":{ "adiposePC":{"value":23.1,"dist":"lognormal","cv":0.3}, "brainPC":{"value":2.2,"dist":"lognormal","cv":0.3}, "heartPC":{"value":4.3}, "kidneyPC":{"value":5.2}, "liverPC":{"value":9.1}, "lungPC":{"value":5.3}, "musclePC":{"value":2.4}, "remainderPC":{"value":16.5}, "skinPC":{"value":3.2,"dist":"lognormal","cv":0.3}, "splanchnicPC":{"value":4.3}, "stomachPC":{"value":4.5}, "testesPC":{"value":4.7}, "flowNotes":"liverOutFlow is sum of liver,splanchnic and stomach", "flowNotes1":"liverOutFlow=3.55+20.25+1.9", "adiposeFlow":{"value":2.55,"unit":"ml/min"}, "brainFlow":{"value":0.78,"unit":"ml/min"}, "heartFlow":{"value":4.2,"unit":"ml/min"}, "kidneyFlow":{"value":16.61,"unit":"ml/min"}, "liverInFlow":{"value":3.55,"unit":"ml/min"}, "liverOutFlow":{"value":25.7,"unit":"ml/min"}, "totalFlow":{"value":80,"unit":"ml/min"}, "muscleFlow":{"value":16.25,"unit":"ml/min"}, "skinFlow":{"value":7.1,"unit":"ml/min"}, "splanchnicFlow":{"value":20.25,"unit":"ml/min"}, "stomachFlow":{"value":1.9,"unit":"ml/min"}, "testesFlow":{"value":1.9,"unit":"ml/min"}, "remainderFlow":{"value":4.91,"unit":"ml/min"}, "adiposeVolume":{"value":10,"unit":"g"}, "brainVolume":{"value":1.2,"unit":"g"}, "heartVolume":{"value":1,"unit":"g"}, "kidneyVolume":{"value":2,"unit":"g"}, "liverVolume":{"value":11,"unit":"g"}, "lungVolume":{"value":1.2,"unit":"g"}, "muscleVolume":{"value":125,"unit":"g"}, "skinVolume":{"value":43.8,"unit":"g"}, "splanchnicVolume":{"value":15,"unit":"g"}, "stomachVolume":{"value":1.1,"unit":"g"}, "testesVolume":{"value":2.5,"unit":"g"}, "remainderVolume":{"value":15.8,"unit":"g"}, "venousVolume":{"value":13.6,"unit":"g"}, "arterialVolume":{"value":6.8,"unit":"g"}, "liverToExcrementNotes":"CL=422 ml/min,PC=9.1,f=0.15,V=11g->k1=0.0105/s", "k1":{"value":0.0105,"unit":"1/s"}} }