{ "timeUnit":"min", "compartments":[ "redBloodCells","plasma","venous","kidney","urine", "richlyPerfused","fat","slowlyPerfused","hair", "brainBlood","brain","placenta", "liver","gut","intestine","feces","inorganicMercury"], "commentParameters":"every parameter must have a value, name is optional and used in SE computation", "volumeComment":"in a compartment w/o volume, value is mass", "volumes":{ "plasma":"plasmaVolume", "venous":"plasmaVolume", "kidney":"kidneyVolume", "richlyPerfused":"richlyPerfusedVolume", "fat":"fatVolume", "slowlyPerfused":"slowlyPerfusedVolume", "brainBlood":"brainBloodVolume", "placenta":"placentaVolume", "gut":"gutVolume", "intestine":"intestineVolume", "redBloodCells":"redBloodCellsVolume", "hair":"hairVolume", "brain":"brainVolume", "liver":"liverVolume" }, "flows":{ "(plasma,venous):kidney":"kidneyFlow", "(plasma,venous):richlyPerfused":"richlyPerfusedFlow", "(plasma,venous):fat":"fatFlow", "(plasma,venous):slowlyPerfused":"slowlyPerfusedFlow", "(plasma,venous):brainBlood":"brainBloodFlow", "(plasma,venous):placenta":"placentaFlow", "plasma:liver":"liverInFlow", "liver:venous":"liverOutFlow", "(plasma,liver):gut":"gutFlow", "plasma:venous":"plasmaFlow"}, "commentSources":"constants in concentration units per s", "commentHeavyside":"value is mass of exogene/volume of container/duration", "sources":{ "intestine":{"name":"constant","value":0.0486,"unit":"ug/min"}}, "commentBindings":"split to flow and diffusion dominated", "bindings": { "flowComments":"group common sources or targets with brackets", "flow":[ "(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver)->venous", "gut->liver", "plasma->(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver,gut)", "venous->plasma"], "diffusion":{ "plasma->redBloodCells":"kRBC", "redBloodCells->plasma":"kRBC", "kidney->urine":"kU", "slowlyPerfused->hair":"kH", "hair->slowlyPerfused":"kH", "brainBlood->brain":"kBR", "liver->intestine":"kB", "liver->inorganicMercury":"kI", "intestine->gut":"kR", "intestine->inorganicMercury":"kD", "intestine->feces":"kF", "inorganicMercury->feces":"kF1"}}, "pcComments":"always related to outflow of organs", "partitionCoefficients":{ "kidney":"kidneyPC", "richlyPerfused":"richlyPerfusedPC", "fat":"fatPC", "slowlyPerfused":"slowlyPerfusedPC", "brainBlood":"brainBloodPC", "placenta":"placentaPC", "liver":"liverPC", "gut":"gutPC", "brainBlood->brain":"brainPC", "hair->slowlyPerfused":"hairPC", "redBloodCells->plasma":"rbcPC"}, "parameters":{ "kidneyPC":{"value":4.0}, "richlyPerfusedPC":{"value":1}, "fatPC":{"value":0.15}, "slowlyPerfusedPC":{"value":2}, "brainBloodPC":{"value":1}, "brainPC":{"value":3}, "hairPC":{"value":248.7}, "placentaPC":{"value":2}, "liverPC":{"value":5}, "gutPC":{"value":1}, "rbcPC":{"value":12}, "flowNotes":"assuming 70kg individual, fetus at 0.1kg", "plasmaFlow":{"value":8.067,"unit":"l/min"}, "kidneyFlow":{"value":1.412,"unit":"l/min"}, "richlyPerfusedFlow":{"value":1.484,"unit":"l/min"}, "fatFlow":{"value":0.419,"unit":"l/min"}, "slowlyPerfusedFlow":{"value":2.01,"unit":"l/min"}, "brainBloodFlow":{"value":0.920,"unit":"l/min"}, "placentaFlow":{"value":0.173,"unit":"l/min"}, "liverInFlow":{"value":0.391,"unit":"l/min"}, "liverOutFlow":{"value":1.928,"unit":"l/min"}, "gutFlow":{"value":1.538,"unit":"l/min"}, "plasmaVolume":{"value":1.64,"unit":"kg"}, "redBloodCellsVolume":{"value":1.64,"unit":"kg"}, "kidneyVolume":{"value":0.28,"unit":"kg"}, "richlyPerfusedVolume":{"value":7,"unit":"kg"}, "fatVolume":{"value":19.11,"unit":"kg"}, "hairVolume":{"value":0.14,"unit":"kg"}, "slowlyPerfusedVolume":{"value":24.5,"unit":"kg"}, "brainBloodVolume":{"value":0.49,"unit":"kg"}, "brainVolume":{"value":1.4,"unit":"kg"}, "placentaVolume":{"value":0.0431,"unit":"kg"}, "liverVolume":{"value":1.82,"unit":"kg"}, "gutVolume":{"value":1.19,"unit":"kg"}, "intestineVolume":{"value":0.98,"unit":"kg"}, "kRBC":{"value":0.60,"unit":"l/min"}, "kU":{"value":0,"unit":"l/min"}, "commentkH":"assume pc-times larger input flow, 2.823e-6*248.7", "kH":{"value":7.021e-4,"unit":"l/min"}, "kBR":{"value":4.033e-3,"unit":"l/min"}, "kI":{"value":4.033e-6,"unit":"l/min"}, "kB":{"value":4.033e-5,"unit":"l/min"}, "kD":{"value":4.033e-5,"unit":"l/min"}, "kF":{"value":8.066e-5,"unit":"l/min"}, "kF1":{"value":0,"unit":"l/min"}, "kR":{"value":2.016e-3,"unit":"l/min"}} }