PBPK_public/models/humanHG_pregnancy.json

{
   "timeUnit":"min",
   "compartments":[
      "redBloodCells","plasma","venous","kidney","urine",
      "richlyPerfused","fat","slowlyPerfused","hair",
      "brainBlood","brain","placenta",
      "liver","gut","intestine","feces","inorganicMercury"],
   "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
   "volumeComment":"in a compartment w/o volume, value is mass",
   "volumes":{
      "plasma":"plasmaVolume",
      "venous":"plasmaVolume",
      "kidney":"kidneyVolume",
      "richlyPerfused":"richlyPerfusedVolume",
      "fat":"fatVolume",
      "slowlyPerfused":"slowlyPerfusedVolume",
      "brainBlood":"brainBloodVolume",
      "placenta":"placentaVolume",
      "gut":"gutVolume",
      "intestine":"intestineVolume",
      "redBloodCells":"redBloodCellsVolume",
      "hair":"hairVolume",
      "brain":"brainVolume",
      "liver":"liverVolume"
      },
   "flows":{
      "(plasma,venous):kidney":"kidneyFlow",
      "(plasma,venous):richlyPerfused":"richlyPerfusedFlow",
      "(plasma,venous):fat":"fatFlow",
      "(plasma,venous):slowlyPerfused":"slowlyPerfusedFlow",
      "(plasma,venous):brainBlood":"brainBloodFlow",
      "(plasma,venous):placenta":"placentaFlow",
      "plasma:liver":"liverInFlow",
      "liver:venous":"liverOutFlow",
      "(plasma,liver):gut":"gutFlow",
      "plasma:venous":"plasmaFlow"},
   "commentSources":"constants in concentration units per s",
   "commentHeavyside":"value is mass of exogene/volume of container/duration",
   "sources":{
      "intestine":{"name":"constant","value":0.0486,"unit":"ug/min"}},
   "commentBindings":"split to flow and diffusion dominated",
   "bindings": {
      "flowComments":"group common sources or targets with brackets",
      "flow":[
         "(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver)->venous",
         "gut->liver",
         "plasma->(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver,gut)",
         "venous->plasma"],
      "diffusion":{
         "plasma->redBloodCells":"kRBC",
         "redBloodCells->plasma":"kRBC",
         "kidney->urine":"kU",
         "slowlyPerfused->hair":"kH",
         "hair->venous":"kH",
         "brainBlood->brain":"kBR",
         "liver->intestine":"kB",
         "liver->inorganicMercury":"kI",
         "intestine->gut":"kR",
         "intestine->inorganicMercury":"kD",
         "intestine->feces":"kF",
         "inorganicMercury->feces":"kF1"}},
    "pcComments":"always related to outflow of organs", 
    "partitionCoefficients":{
       "kidney":"kidneyPC",
       "richlyPerfused":"richlyPerfusedPC",
       "fat":"fatPC",
       "slowlyPerfused":"slowlyPerfusedPC",
       "brainBlood":"brainBloodPC",
       "placenta":"placentaPC",
       "liver":"liverPC",
       "gut":"gutPC",
       "brainBlood->brain":"brainPC",
       "hair->venous":"hairPC",
       "redBloodCells->plasma":"rbcPC"},
     "parameters":"humanHG_parameters1.json"
}