PBPK_public/rezultati/least_squares/run3/parameters.json

{
    "parameters": {
        "commentsInput": "X",
        "venousInput": {
            "value": 0.01,
            "commentUnit": "sameUnitAsVolumes",
            "name": "venousInput"
        },
        "_venousInput": {
            "function": "venousInput"
        },
        "inputA": {
            "value": 250000.0,
            "commentUnit": "AU;reported concentrations are in AU/volumeUnit",
            "dist": "normal",
            "cv": 0
        },
        "inputTau": {
            "value": 1,
            "commentUnit": "sameAsTimeUnit",
            "dist": "normal",
            "cv": 0
        },
        "commentPC": "X",
        "adiposePC": {
            "value": 218.1815909221639,
            "dist": "lognormal",
            "cv": 0.3,
            "name": "adiposePC"
        },
        "brainPC": {
            "value": 0.6743841035095305,
            "dist": "lognormal",
            "cv": 0.3,
            "name": "brainPC"
        },
        "heartPC": {
            "value": 2.3,
            "name": "heartPC"
        },
        "kidneyPC": {
            "value": 3.2,
            "name": "kidneyPC"
        },
        "liverPC": {
            "value": 7.172807904782884,
            "name": "liverPC"
        },
        "lungPC": {
            "value": 5.29459691835908,
            "name": "lungPC"
        },
        "musclePC": {
            "value": 300.2280320612966,
            "name": "musclePC"
        },
        "remainderPC": {
            "value": 13.5,
            "name": "remainderPC"
        },
        "skinPC": {
            "value": 3.2,
            "dist": "lognormal",
            "cv": 0.3,
            "name": "skinPC"
        },
        "splanchnicPC": {
            "value": 4.3,
            "name": "splanchnicPC"
        },
        "stomachPC": {
            "value": 4.5,
            "name": "stomachPC"
        },
        "testesPC": {
            "value": 4.7,
            "name": "testesPC"
        },
        "commentFlows": "X",
        "flowNotes": "liverOutFlow is sum of liver,splanchnic and stomach",
        "adiposeFlow": {
            "value": 2.0995625885549836,
            "unit": "ml/min",
            "name": "adiposeFlow"
        },
        "brainFlow": {
            "value": 1.006747964240166,
            "unit": "ml/min",
            "name": "brainFlow"
        },
        "heartFlow": {
            "value": 5.991169953438709,
            "unit": "ml/min",
            "name": "heartFlow"
        },
        "kidneyFlow": {
            "value": 8.045125957935333,
            "unit": "ml/min",
            "name": "kidneyFlow"
        },
        "liverInFlow": {
            "value": 4.439638876424774,
            "unit": "ml/min",
            "name": "liverInFlow"
        },
        "liverOutFlow": {
            "derived": "liverOutFlow",
            "name": "liverOutFlow"
        },
        "gutOutFlow": {
            "derived": "gutOutFlow",
            "name": "gutOutFlow"
        },
        "totalFlow": {
            "value": 80.15595121578058,
            "unit": "ml/min",
            "name": "totalFlow"
        },
        "muscleFlow": {
            "value": 24.28187063833492,
            "unit": "ml/min",
            "name": "muscleFlow"
        },
        "skinFlow": {
            "value": 8.49414665258744,
            "unit": "ml/min",
            "name": "skinFlow"
        },
        "splanchnicFlow": {
            "value": 3.4958501465638716,
            "unit": "ml/min",
            "name": "splanchnicFlow"
        },
        "stomachFlow": {
            "value": 0.029874094495784567,
            "unit": "ml/min",
            "name": "stomachFlow"
        },
        "testesFlow": {
            "value": 0.31648763625768067,
            "unit": "ml/min",
            "name": "testesFlow"
        },
        "remainderFlow": {
            "value": 10.850053519164424,
            "unit": "ml/min",
            "name": "remainderFlow"
        },
        "adiposeVolume": {
            "value": 8,
            "unit": "g",
            "name": "adiposeVolume"
        },
        "brainVolume": {
            "value": 1.2,
            "unit": "g",
            "name": "brainVolume"
        },
        "heartVolume": {
            "value": 1,
            "unit": "g",
            "name": "heartVolume"
        },
        "kidneyVolume": {
            "value": 0.6130980877965343,
            "unit": "g",
            "name": "kidneyVolume"
        },
        "liverVolume": {
            "value": 9.57721143352948,
            "unit": "g",
            "name": "liverVolume"
        },
        "lungVolume": {
            "value": 1.1926846459312106,
            "unit": "g",
            "name": "lungVolume"
        },
        "muscleVolume": {
            "value": 183.49790794877356,
            "unit": "g",
            "name": "muscleVolume"
        },
        "skinVolume": {
            "value": 50.7907779652884,
            "unit": "g",
            "name": "skinVolume"
        },
        "splanchnicVolume": {
            "value": 2.5124278822927564,
            "unit": "g",
            "name": "splanchnicVolume"
        },
        "stomachVolume": {
            "value": 0.016783598017874313,
            "unit": "g",
            "name": "stomachVolume"
        },
        "testesVolume": {
            "value": 0.4037566293871145,
            "unit": "g",
            "name": "testesVolume"
        },
        "remainderVolume": {
            "value": 33.79422185658802,
            "unit": "g",
            "name": "remainderVolume"
        },
        "venousVolume": {
            "value": 13.6,
            "unit": "g",
            "dist": "normal",
            "cv": 0,
            "name": "venousVolume"
        },
        "arterialVolume": {
            "value": 12.12168846959525,
            "unit": "g",
            "name": "arterialVolume"
        },
        "liverToExcrementNotes": "CL=422 ml/min,PC=9.1,f=0.15,V=11g->k1=0.0105/s",
        "k1": {
            "value": 0.010414896050882904,
            "unit": "1/s",
            "name": "k1"
        },
        "one": {
            "value": 1,
            "name": "one"
        },
        "zero": {
            "value": 0
        },
        "two": {
            "value": 2
        }
    },
    "derivedParameters": {
        "liverOutFlow": {
            "type": "sum",
            "a": "liverInFlow",
            "b": "gutOutFlow"
        },
        "gutOutFlow": {
            "type": "sum",
            "a": "splanchnicFlow",
            "b": "stomachFlow"
        }
    },
    "functions": {
        "venousInput": {
            "type": "exp",
            "A": "inputA",
            "tau": "inputTau"
        }
    }
}