humanHG.json 4.7 KB

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  1. {
  2. "compartments":[
  3. "redBloodCells","arterial","venous","kidney","urine",
  4. "richlyPerfused","fat","slowlyPerfused","hair",
  5. "brainBlood","brain","placenta",
  6. "liver","gut","intestine","feces","inorganicMercury"],
  7. "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
  8. "volumes":{
  9. "plasma":"plasmaVolume",
  10. "venous":"plasmaVolume",
  11. "kidney":"kidneyVolume",
  12. "richlyPerfused":"richlyPerfusedVolume",
  13. "fat":"fatVolume",
  14. "slowlyPerfused":"slowlyPerfusedVolume",
  15. "brainBlood":"brainBloodVolume",
  16. "placenta":"placentaVolume",
  17. "gut":"gutVolume",
  18. "intestine":"intestineVolume"},
  19. "flows":{
  20. "(plasma,venous):kidney":"kidneyFlow",
  21. "(plasma,venous):richlyPerfused":"richlyPerfusedFlow",
  22. "(plasma,venous):fat":"fatFlow",
  23. "(plasma,venous):slowlyPerfused":"slowlyPerfusedFlow",
  24. "(plasma,venous):brainBlood":"brainBloodFlow",
  25. "(plasma,venous):placenta":"placentaFlow",
  26. "plasma:liver":"liverInFlow",
  27. "liver:venous":"liverOutFlow",
  28. "(plasma,liver):gut":"gutFlow",
  29. "plasma:venous":"plasmaFlow"},
  30. "commentSources":"constants in concentration units per s",
  31. "commentHeavyside":"value is mass of exogene/volume of container/duration",
  32. "sources":{
  33. "arterial":{"name":"exponential","k":-0.005,"constant":0},
  34. "venous":{"name":"Heavyside","limit":3,"value":1.22e4}},
  35. "commentBindings":"split to flow and diffusion dominated",
  36. "bindings": {
  37. "flowComments":"group common sources or targets with brackets",
  38. "flow":[
  39. "(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver)->venous",
  40. "gut->liver",
  41. "plasma->(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver,gut)",
  42. "venous->plasma"],
  43. "diffusion":{
  44. "plasma->redBloodCells":"kRBC",
  45. "kidney->urine":"kU",
  46. "slowlyPerfused->hair":"kH",
  47. "brainBlood->brain":"kBR",
  48. "liver->intestine":"kB",
  49. "liver->inorganicMercury":"kI",
  50. "intestine->gut":"kR",
  51. "intestine->inorganicMercury":"kD",
  52. "intestine->feces":"kF",
  53. "inorganicMercury->feces":"kF1"}},
  54. "pcComments":"always related to outflow of organs",
  55. "partitionCoefficients":{
  56. "kidney":"kidneyPC",
  57. "richlyPerfused":"richlyPerfusedPC",
  58. "fat":"fatPC",
  59. "slowlyPerfused":"slowlyPerfusedPC",
  60. "brainBlood":"brainBloodPC",
  61. "placenta":"placentaPC",
  62. "liver":"liverPC",
  63. "gut":"gutPC",
  64. "brainBlood->brain":"brainPC",
  65. "slowlyPerfused->hair":"hairPC",
  66. "plasma->redBloodCells":"rbcPC"},
  67. "parameters":{
  68. "kidneyPC":{"value":4.0},
  69. "richlyPerfusedPC":{"value":1},
  70. "fatPC":{"value":0.15},
  71. "slowlyPerfusedPC":{"value":2},
  72. "brainBloodPC":{"value":1},
  73. "brainPC":{"value":3},
  74. "hairPC":{"value":248.7},
  75. "placentaPC":{"value":2},
  76. "liverPC":{"value":5},
  77. "gutPC":{"value":1},
  78. "rbcPC":{"value":12},
  79. "flowNotes":"assuming 70kg individual, fetus at 0.1kg",
  80. "kidneyFlow":{"value":1.412,"unit":"l/min"},
  81. "richlyPerfusedFlow":{"value":1.484,"unit":"l/min"},
  82. "fatFlow":{"value":0.419,"unit":"l/min"},
  83. "slowlyPerfusedFlow":{"value":2.01,"unit":"l/min"},
  84. "brainBloodFlow":{"value":0.920,"unit":"l/min"},
  85. "placentaFlow":{"value":0.173,"unit":"l/min"},
  86. "liverInFlow":{"value":0.391,"unit":"l/min"},
  87. "liverOutFlow":{"value":1.928,"unit":"l/min"},
  88. "gutFlow":{"value":1.538,"unit":"l/min"},
  89. "plasmaVolume":{"value":1.64,"unit":"kg"},
  90. "redBloodCellsVolume":{"value":1.64,"unit":"kg"},
  91. "kidneyVolume":{"value":0.28,"unit":"kg"},
  92. "richlyPerfusedVolume":{"value":7,"unit":"kg"},
  93. "fatVolume":{"value":19.11,"unit":"kg"},
  94. "hairVolume":{"value":0.14,"unit":"kg"},
  95. "slowlyPerfusedVolume":{"value":24.5,"unit":"kg"},
  96. "brainBloodVolume":{"value":0.49,"unit":"kg"},
  97. "brainVolume":{"value":1.4,"unit":"kg"},
  98. "placentaVolume":{"value":0.0431,"unit":"kg"},
  99. "liverVolume":{"value":1.82,"unit":"kg"},
  100. "gutVolume":{"value":1.19,"unit":"kg"},
  101. "intestineVolume":{"value":0.98,"unit":"kg"},
  102. "kRBC":{"value":0.025,"unit":"l/min"},
  103. "kU":{"value":0,"unit":"l/min"},
  104. "kH":{"value":1.167e-7,"unit":"l/min"},
  105. "kBR":{"value":1.67e-4,"unit":"l/min"},
  106. "kI":{"value":1.67e-7,"unit":"l/min"},
  107. "kB":{"value":1.67e-6,"unit":"l/min"},
  108. "kD":{"value":1.67e-6,"unit":"l/min"},
  109. "kF":{"value":3.33e-6,"unit":"l/min"},
  110. "kF1":{"value":0,"unit":"l/min"},
  111. "kR":{"value":8.33e-5,"unit":"l/min"}
  112. }