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- {
- "compartments":[
- "redBloodCells","arterial","venous","kidney","urine",
- "richlyPerfused","fat","slowlyPerfused","hair",
- "brainBlood","brain","placenta",
- "liver","gut","intestine","feces","inorganicMercury"],
- "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
- "volumes":{
- "plasma":"plasmaVolume",
- "venous":"plasmaVolume",
- "kidney":"kidneyVolume",
- "richlyPerfused":"richlyPerfusedVolume",
- "fat":"fatVolume",
- "slowlyPerfused":"slowlyPerfusedVolume",
- "brainBlood":"brainBloodVolume",
- "placenta":"placentaVolume",
- "gut":"gutVolume",
- "intestine":"intestineVolume"},
- "flows":{
- "(plasma,venous):kidney":"kidneyFlow",
- "(plasma,venous):richlyPerfused":"richlyPerfusedFlow",
- "(plasma,venous):fat":"fatFlow",
- "(plasma,venous):slowlyPerfused":"slowlyPerfusedFlow",
- "(plasma,venous):brainBlood":"brainBloodFlow",
- "(plasma,venous):placenta":"placentaFlow",
- "plasma:liver":"liverInFlow",
- "liver:venous":"liverOutFlow",
- "(plasma,liver):gut":"gutFlow",
- "plasma:venous":"plasmaFlow"},
- "commentSources":"constants in concentration units per s",
- "commentHeavyside":"value is mass of exogene/volume of container/duration",
- "sources":{
- "arterial":{"name":"exponential","k":-0.005,"constant":0},
- "venous":{"name":"Heavyside","limit":3,"value":1.22e4}},
- "commentBindings":"split to flow and diffusion dominated",
- "bindings": {
- "flowComments":"group common sources or targets with brackets",
- "flow":[
- "(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver)->venous",
- "gut->liver",
- "plasma->(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver,gut)",
- "venous->plasma"],
- "diffusion":{
- "plasma->redBloodCells":"kRBC",
- "kidney->urine":"kU",
- "slowlyPerfused->hair":"kH",
- "brainBlood->brain":"kBR",
- "liver->intestine":"kB",
- "liver->inorganicMercury":"kI",
- "intestine->gut":"kR",
- "intestine->inorganicMercury":"kD",
- "intestine->feces":"kF",
- "inorganicMercury->feces":"kF1"}},
- "pcComments":"always related to outflow of organs",
- "partitionCoefficients":{
- "kidney":"kidneyPC",
- "richlyPerfused":"richlyPerfusedPC",
- "fat":"fatPC",
- "slowlyPerfused":"slowlyPerfusedPC",
- "brainBlood":"brainBloodPC",
- "placenta":"placentaPC",
- "liver":"liverPC",
- "gut":"gutPC",
- "brainBlood->brain":"brainPC",
- "slowlyPerfused->hair":"hairPC",
- "plasma->redBloodCells":"rbcPC"},
- "parameters":{
- "kidneyPC":{"value":4.0},
- "richlyPerfusedPC":{"value":1},
- "fatPC":{"value":0.15},
- "slowlyPerfusedPC":{"value":2},
- "brainBloodPC":{"value":1},
- "brainPC":{"value":3},
- "hairPC":{"value":248.7},
- "placentaPC":{"value":2},
- "liverPC":{"value":5},
- "gutPC":{"value":1},
- "rbcPC":{"value":12},
- "flowNotes":"assuming 70kg individual, fetus at 0.1kg",
- "kidneyFlow":{"value":1.412,"unit":"l/min"},
- "richlyPerfusedFlow":{"value":1.484,"unit":"l/min"},
- "fatFlow":{"value":0.419,"unit":"l/min"},
- "slowlyPerfusedFlow":{"value":2.01,"unit":"l/min"},
- "brainBloodFlow":{"value":0.920,"unit":"l/min"},
- "placentaFlow":{"value":0.173,"unit":"l/min"},
- "liverInFlow":{"value":0.391,"unit":"l/min"},
- "liverOutFlow":{"value":1.928,"unit":"l/min"},
- "gutFlow":{"value":1.538,"unit":"l/min"},
- "plasmaVolume":{"value":1.64,"unit":"kg"},
- "redBloodCellsVolume":{"value":1.64,"unit":"kg"},
- "kidneyVolume":{"value":0.28,"unit":"kg"},
- "richlyPerfusedVolume":{"value":7,"unit":"kg"},
- "fatVolume":{"value":19.11,"unit":"kg"},
- "hairVolume":{"value":0.14,"unit":"kg"},
- "slowlyPerfusedVolume":{"value":24.5,"unit":"kg"},
- "brainBloodVolume":{"value":0.49,"unit":"kg"},
- "brainVolume":{"value":1.4,"unit":"kg"},
- "placentaVolume":{"value":0.0431,"unit":"kg"},
- "liverVolume":{"value":1.82,"unit":"kg"},
- "gutVolume":{"value":1.19,"unit":"kg"},
- "intestineVolume":{"value":0.98,"unit":"kg"},
- "kRBC":{"value":0.025,"unit":"l/min"},
- "kU":{"value":0,"unit":"l/min"},
- "kH":{"value":1.167e-7,"unit":"l/min"},
- "kBR":{"value":1.67e-4,"unit":"l/min"},
- "kI":{"value":1.67e-7,"unit":"l/min"},
- "kB":{"value":1.67e-6,"unit":"l/min"},
- "kD":{"value":1.67e-6,"unit":"l/min"},
- "kF":{"value":3.33e-6,"unit":"l/min"},
- "kF1":{"value":0,"unit":"l/min"},
- "kR":{"value":8.33e-5,"unit":"l/min"}
- }
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