PBPK_public/models/cDiazepam_parameters2.json

{
    "parameters": {
        "commentsInput": "X",
        "venousInput": {
            "value": 0.0,
            "commentUnit": "sameUnitAsVolumes"
        },
        "_venousInput": {
            "function": "venousInput"
        },
        "inputA": {
            "value": 0.01,
            "commentUnit": "sameAsVolumes"
        },
        "inputTau": {
            "value": 1,
            "commentUnit": "sameAsTimeUnit"
        },
        "commentPC": "X",
        "adiposePC": {
            "value": 23.1,
            "dist": "lognormal",
            "cv": 0.3
        },
        "brainPC": {
            "value": 2.2,
            "dist": "lognormal",
            "cv": 0.3
        },
        "heartPC": {
            "value": 4.3
        },
        "kidneyPC": {
            "value": 5.2
        },
        "liverPC": {
            "value": 9.1
        },
        "lungPC": {
            "value": 5.3
        },
        "musclePC": {
            "value": 2.4
        },
        "remainderPC": {
            "value": 16.5
        },
        "skinPC": {
            "value": 3.2,
            "dist": "lognormal",
            "cv": 0.3
        },
        "splanchnicPC": {
            "value": 4.3
        },
        "stomachPC": {
            "value": 4.5
        },
        "testesPC": {
            "value": 4.7
        },
        "commentFlows": "X",
        "flowNotes": "liverOutFlow is sum of liver,splanchnic and stomach",
        "adiposeFlow": {
            "value": 2.55,
            "unit": "ml/min"
        },
        "brainFlow": {
            "value": 0.78,
            "unit": "ml/min"
        },
        "heartFlow": {
            "value": 4.2,
            "unit": "ml/min"
        },
        "kidneyFlow": {
            "value": 16.61,
            "unit": "ml/min"
        },
        "liverInFlow": {
            "value": 3.55,
            "unit": "ml/min"
        },
        "liverOutFlow": {
            "derived": "liverOutFlow"
        },
        "gutOutFlow": {
            "derived": "gutOutFlow"
        },
        "totalFlow": {
            "value": 80,
            "unit": "ml/min"
        },
        "muscleFlow": {
            "value": 16.25,
            "unit": "ml/min"
        },
        "skinFlow": {
            "value": 7.1,
            "unit": "ml/min"
        },
        "splanchnicFlow": {
            "value": 20.25,
            "unit": "ml/min"
        },
        "stomachFlow": {
            "value": 1.9,
            "unit": "ml/min"
        },
        "testesFlow": {
            "value": 1.9,
            "unit": "ml/min"
        },
        "remainderFlow": {
            "value": 4.91,
            "unit": "ml/min"
        },
        "adiposeVolume": {
            "value": 10,
            "unit": "g"
        },
        "brainVolume": {
            "value": 1.2,
            "unit": "g"
        },
        "heartVolume": {
            "value": 1,
            "unit": "g"
        },
        "kidneyVolume": {
            "value": 2,
            "unit": "g"
        },
        "liverVolume": {
            "value": 11,
            "unit": "g"
        },
        "lungVolume": {
            "value": 1.2,
            "unit": "g"
        },
        "muscleVolume": {
            "value": 125,
            "unit": "g"
        },
        "skinVolume": {
            "value": 43.8,
            "unit": "g"
        },
        "splanchnicVolume": {
            "value": 15,
            "unit": "g"
        },
        "stomachVolume": {
            "value": 1.1,
            "unit": "g"
        },
        "testesVolume": {
            "value": 2.5,
            "unit": "g"
        },
        "remainderVolume": {
            "value": 15.8,
            "unit": "g"
        },
        "venousVolume": {
            "value": 13.6,
            "unit": "g"
        },
        "arterialVolume": {
            "value": 6.8,
            "unit": "g"
        },
        "liverToExcrementNotes": "CL=422 ml/min,PC=9.1,f=0.15,V=11g->k1=0.0105/s",
        "k1": {
            "value": 0.0105,
            "unit": "1/s"
        }
    },
    "derivedParameters": {
        "liverOutFlow": {
            "type": "sum",
            "a": "liverInFlow",
            "b": "gutOutFlow"
        },
        "gutOutFlow": {
            "type": "sum",
            "a": "splanchnicFlow",
            "b": "stomachFlow"
        }
    },
    "functions": {
        "venousInput": {
            "type": "exp",
            "A": "inputA",
            "tau": "inputTau"
        }
    },
    "original_parameters": {
        "commentsInput": "X",
        "venousInput": {
            "value": 0.0,
            "commentUnit": "sameUnitAsVolumes",
            "name": "venousInput"
        },
        "_venousInput": {
            "function": "venousInput"
        },
        "inputA": {
            "value": 0.01,
            "commentUnit": "sameAsVolumes"
        },
        "inputTau": {
            "value": 1,
            "commentUnit": "sameAsTimeUnit"
        },
        "commentPC": "X",
        "adiposePC": {
            "value": 23.1,
            "dist": "lognormal",
            "cv": 0.3,
            "name": "adiposePC"
        },
        "brainPC": {
            "value": 2.2,
            "dist": "lognormal",
            "cv": 0.3,
            "name": "brainPC"
        },
        "heartPC": {
            "value": 4.3,
            "name": "heartPC"
        },
        "kidneyPC": {
            "value": 5.2,
            "name": "kidneyPC"
        },
        "liverPC": {
            "value": 9.1,
            "name": "liverPC"
        },
        "lungPC": {
            "value": 5.3,
            "name": "lungPC"
        },
        "musclePC": {
            "value": 2.4,
            "name": "musclePC"
        },
        "remainderPC": {
            "value": 16.5,
            "name": "remainderPC"
        },
        "skinPC": {
            "value": 3.2,
            "dist": "lognormal",
            "cv": 0.3,
            "name": "skinPC"
        },
        "splanchnicPC": {
            "value": 4.3,
            "name": "splanchnicPC"
        },
        "stomachPC": {
            "value": 4.5,
            "name": "stomachPC"
        },
        "testesPC": {
            "value": 4.7,
            "name": "testesPC"
        },
        "commentFlows": "X",
        "flowNotes": "liverOutFlow is sum of liver,splanchnic and stomach",
        "adiposeFlow": {
            "value": 2.55,
            "unit": "ml/min",
            "name": "adiposeFlow"
        },
        "brainFlow": {
            "value": 0.78,
            "unit": "ml/min",
            "name": "brainFlow"
        },
        "heartFlow": {
            "value": 4.2,
            "unit": "ml/min",
            "name": "heartFlow"
        },
        "kidneyFlow": {
            "value": 16.61,
            "unit": "ml/min",
            "name": "kidneyFlow"
        },
        "liverInFlow": {
            "value": 3.55,
            "unit": "ml/min",
            "name": "liverInFlow"
        },
        "liverOutFlow": {
            "derived": "liverOutFlow",
            "name": "liverOutFlow"
        },
        "gutOutFlow": {
            "derived": "gutOutFlow",
            "name": "gutOutFlow"
        },
        "totalFlow": {
            "value": 80,
            "unit": "ml/min",
            "name": "totalFlow"
        },
        "muscleFlow": {
            "value": 16.25,
            "unit": "ml/min",
            "name": "muscleFlow"
        },
        "skinFlow": {
            "value": 7.1,
            "unit": "ml/min",
            "name": "skinFlow"
        },
        "splanchnicFlow": {
            "value": 20.25,
            "unit": "ml/min",
            "name": "splanchnicFlow"
        },
        "stomachFlow": {
            "value": 1.9,
            "unit": "ml/min",
            "name": "stomachFlow"
        },
        "testesFlow": {
            "value": 1.9,
            "unit": "ml/min",
            "name": "testesFlow"
        },
        "remainderFlow": {
            "value": 4.91,
            "unit": "ml/min",
            "name": "remainderFlow"
        },
        "adiposeVolume": {
            "value": 10,
            "unit": "g",
            "name": "adiposeVolume"
        },
        "brainVolume": {
            "value": 1.2,
            "unit": "g",
            "name": "brainVolume"
        },
        "heartVolume": {
            "value": 1,
            "unit": "g",
            "name": "heartVolume"
        },
        "kidneyVolume": {
            "value": 2,
            "unit": "g",
            "name": "kidneyVolume"
        },
        "liverVolume": {
            "value": 11,
            "unit": "g",
            "name": "liverVolume"
        },
        "lungVolume": {
            "value": 1.2,
            "unit": "g",
            "name": "lungVolume"
        },
        "muscleVolume": {
            "value": 125,
            "unit": "g",
            "name": "muscleVolume"
        },
        "skinVolume": {
            "value": 43.8,
            "unit": "g",
            "name": "skinVolume"
        },
        "splanchnicVolume": {
            "value": 15,
            "unit": "g",
            "name": "splanchnicVolume"
        },
        "stomachVolume": {
            "value": 1.1,
            "unit": "g",
            "name": "stomachVolume"
        },
        "testesVolume": {
            "value": 2.5,
            "unit": "g",
            "name": "testesVolume"
        },
        "remainderVolume": {
            "value": 15.8,
            "unit": "g",
            "name": "remainderVolume"
        },
        "venousVolume": {
            "value": 13.6,
            "unit": "g",
            "name": "venousVolume"
        },
        "arterialVolume": {
            "value": 6.8,
            "unit": "g",
            "name": "arterialVolume"
        },
        "liverToExcrementNotes": "CL=422 ml/min,PC=9.1,f=0.15,V=11g->k1=0.0105/s",
        "k1": {
            "value": 0.0105,
            "unit": "1/s",
            "name": "k1"
        },
        "one": {
            "value": 1,
            "name": "one"
        },
        "zero": {
            "value": 0
        },
        "two": {
            "value": 2
        }
    }
}