PBPK_public/rezultati/run3/updated_parameters.json

{
    "parameters": {
        "commentsInput": "X",
        "venousInput": {
            "value": 0.01,
            "commentUnit": "sameUnitAsVolumes",
            "name": "venousInput"
        },
        "_venousInput": {
            "function": "venousInput"
        },
        "inputA": {
            "value": 250000.0,
            "commentUnit": "AU;reported concentrations are in AU/volumeUnit",
            "dist": "normal",
            "cv": 0
        },
        "inputTau": {
            "value": 1,
            "commentUnit": "sameAsTimeUnit",
            "dist": "normal",
            "cv": 0
        },
        "commentPC": "X",
        "adiposePC": {
            "value": 1.7465988293694654,
            "dist": "lognormal",
            "cv": 0.3,
            "name": "adiposePC"
        },
        "brainPC": {
            "value": -21.595129329777393,
            "dist": "lognormal",
            "cv": 0.3,
            "name": "brainPC"
        },
        "heartPC": {
            "value": 2.3,
            "name": "heartPC"
        },
        "kidneyPC": {
            "value": 3.2,
            "name": "kidneyPC"
        },
        "liverPC": {
            "value": 73.43342162640477,
            "name": "liverPC"
        },
        "lungPC": {
            "value": 5.294331096692011,
            "name": "lungPC"
        },
        "musclePC": {
            "value": 92.2299727216926,
            "name": "musclePC"
        },
        "remainderPC": {
            "value": 13.5,
            "name": "remainderPC"
        },
        "skinPC": {
            "value": 3.2,
            "dist": "lognormal",
            "cv": 0.3,
            "name": "skinPC"
        },
        "splanchnicPC": {
            "value": 4.3,
            "name": "splanchnicPC"
        },
        "stomachPC": {
            "value": 4.5,
            "name": "stomachPC"
        },
        "testesPC": {
            "value": 4.7,
            "name": "testesPC"
        },
        "commentFlows": "X",
        "flowNotes": "liverOutFlow is sum of liver,splanchnic and stomach",
        "adiposeFlow": {
            "value": 2.174584920485238,
            "unit": "ml/min",
            "name": "adiposeFlow"
        },
        "brainFlow": {
            "value": 0.7347954552044431,
            "unit": "ml/min",
            "name": "brainFlow"
        },
        "heartFlow": {
            "value": 5.973143661549732,
            "unit": "ml/min",
            "name": "heartFlow"
        },
        "kidneyFlow": {
            "value": 9.438333587016956,
            "unit": "ml/min",
            "name": "kidneyFlow"
        },
        "liverInFlow": {
            "value": 36.299975332476535,
            "unit": "ml/min",
            "name": "liverInFlow"
        },
        "liverOutFlow": {
            "derived": "liverOutFlow",
            "name": "liverOutFlow"
        },
        "gutOutFlow": {
            "derived": "gutOutFlow",
            "name": "gutOutFlow"
        },
        "totalFlow": {
            "value": 80.27193016146373,
            "unit": "ml/min",
            "name": "totalFlow"
        },
        "muscleFlow": {
            "value": 18.08766250777834,
            "unit": "ml/min",
            "name": "muscleFlow"
        },
        "skinFlow": {
            "value": 8.644953418972285,
            "unit": "ml/min",
            "name": "skinFlow"
        },
        "splanchnicFlow": {
            "value": 18.916221586431863,
            "unit": "ml/min",
            "name": "splanchnicFlow"
        },
        "stomachFlow": {
            "value": -28.780336588095842,
            "unit": "ml/min",
            "name": "stomachFlow"
        },
        "testesFlow": {
            "value": -7.153370524280696,
            "unit": "ml/min",
            "name": "testesFlow"
        },
        "remainderFlow": {
            "value": 4.91,
            "unit": "ml/min",
            "name": "remainderFlow"
        },
        "adiposeVolume": {
            "value": 8,
            "unit": "g",
            "name": "adiposeVolume"
        },
        "brainVolume": {
            "value": 1.2,
            "unit": "g",
            "name": "brainVolume"
        },
        "heartVolume": {
            "value": 1,
            "unit": "g",
            "name": "heartVolume"
        },
        "kidneyVolume": {
            "value": 0.7216561223489145,
            "unit": "g",
            "name": "kidneyVolume"
        },
        "liverVolume": {
            "value": 79.02614901847276,
            "unit": "g",
            "name": "liverVolume"
        },
        "lungVolume": {
            "value": 1.1928692237387737,
            "unit": "g",
            "name": "lungVolume"
        },
        "muscleVolume": {
            "value": 136.96546950816472,
            "unit": "g",
            "name": "muscleVolume"
        },
        "skinVolume": {
            "value": 51.77227525216925,
            "unit": "g",
            "name": "skinVolume"
        },
        "splanchnicVolume": {
            "value": 13.617069468689676,
            "unit": "g",
            "name": "splanchnicVolume"
        },
        "stomachVolume": {
            "value": -16.196226290960496,
            "unit": "g",
            "name": "stomachVolume"
        },
        "testesVolume": {
            "value": -9.140409459100297,
            "unit": "g",
            "name": "testesVolume"
        },
        "remainderVolume": {
            "value": 15.319206674351369,
            "unit": "g",
            "name": "remainderVolume"
        },
        "venousVolume": {
            "value": 13.6,
            "unit": "g",
            "dist": "normal",
            "cv": 0,
            "name": "venousVolume"
        },
        "arterialVolume": {
            "value": 12.06094378520841,
            "unit": "g",
            "name": "arterialVolume"
        },
        "liverToExcrementNotes": "CL=422 ml/min,PC=9.1,f=0.15,V=11g->k1=0.0105/s",
        "k1": {
            "value": -0.2543049806392662,
            "unit": "1/s",
            "name": "k1"
        },
        "one": {
            "value": 1,
            "name": "one"
        },
        "zero": {
            "value": 0
        },
        "two": {
            "value": 2
        }
    },
    "derivedParameters": {
        "liverOutFlow": {
            "type": "sum",
            "a": "liverInFlow",
            "b": "gutOutFlow"
        },
        "gutOutFlow": {
            "type": "sum",
            "a": "splanchnicFlow",
            "b": "stomachFlow"
        }
    },
    "functions": {
        "venousInput": {
            "type": "exp",
            "A": "inputA",
            "tau": "inputTau"
        }
    }
}