PBPK_public/models/humanHG_parameters1.json

{"parameters":{
        "bodyWeight":{"value":70,"units":"kg"},
        "bodyWeight0p75":{"derived":"bwPower0p75"},
        "kidneyPC":{"value":4.0},
        "richlyPerfusedPC":{"value":1},
        "fatPC":{"value":0.15},
        "slowlyPerfusedPC":{"value":2},
        "brainBloodPC":{"value":1},
        "brainPC":{"value":3},
        "hairPCBlood":{"value":248.7,"dist":"lognormal","cv":0.7},
        "hairPC":{"derived":"hairPC"},
        "placentaPC":{"value":2},
	     "liverPC":{"value":5},
        "gutPC":{"value":1},
        "rbcPC":{"value":12},
        "flowNotes":"assuming 70kg individual, fetus at 0.1kg",
        "plasmaFlow":{"value":8.067,"unit":"l/min"},
        "plasmaFlowScaled":{"value":0.333,"unit":"l/min"},
        "kidneyFlow":{"value":1.412,"unit":"l/min"},
        "richlyPerfusedFlow":{"value":1.484,"unit":"l/min"},
        "fatFlow":{"value":0.419,"unit":"l/min"},
        "slowlyPerfusedFlow":{"value":2.01,"unit":"l/min"},
        "brainBloodFlow":{"value":0.920,"unit":"l/min"},
        "placentaFlow":{"value":0.173,"unit":"l/min"},
        "liverInFlow":{"value":0.391,"unit":"l/min"},
        "liverOutFlow":{"value":1.928,"unit":"l/min"},
        "gutFlow":{"value":1.538,"unit":"l/min"},
        "plasmaVolume":{"value":1.64,"unit":"kg"},
        "redBloodCellsVolume":{"value":1.64,"unit":"kg"},
        "kidneyVolume":{"value":0.28,"unit":"kg"},
        "richlyPerfusedVolume":{"value":7,"unit":"kg"},
        "fatVolume":{"value":19.11,"unit":"kg"},
        "hairVolume":{"function":"hairGrowth"},
        "hairGrowthDuration":{"derived":"hairGrowthDuration"},
        "hairVolumeMax":{"derived":"hairVolumeMax"},
        "hairVolumeFraction":{"value":0.002,"dist":"lognormal","cv":0.5},
        "slowlyPerfusedVolume":{"value":24.5,"unit":"kg"},
        "brainBloodVolume":{"value":0.49,"unit":"kg"},
        "brainVolume":{"value":1.4,"unit":"kg"},
        "placentaVolume":{"value":0.0431,"unit":"kg"},
        "liverVolume":{"value":1.82,"unit":"kg"},
        "gutVolume":{"value":1.19,"unit":"kg"},
        "intestineVolume":{"value":0.98,"unit":"kg"},
        "kRBC":{"value":0.60,"unit":"l/min"},
        "kU":{"value":0,"unit":"l/min"},
        "commentkH":"assume pc-times larger input flow, 2.823e-6*248.7",
        "kH":{"value":2.823e-6,"unit":"l/min"},
        "kBR":{"value":4.033e-3,"unit":"l/min"},
        "kI":{"value":4.033e-6,"unit":"l/min"},
        "kB":{"value":4.033e-5,"unit":"l/min"},
        "kD":{"value":4.033e-5,"unit":"l/min"},
        "kF":{"value":8.066e-5,"unit":"l/min"},
        "kF1":{"value":0,"unit":"l/min"},
        "kR":{"value":2.016e-3,"unit":"l/min"},
        "zero":{"value":0},
        "threeQuarters":{"value":0.75},
        "heavisideTransition":{"value":100},
        "hairGrowthStart":{"value":0e6,"unit":"min"},
        "hairGrowthStop":{"derived":"hairGrowthStop"},
        "hairGrowth":{"derived":"hairGrowth"}},
    "functions":{
       "commentHairGrowth":"2yr hair growth to a total mass of 140g",
       "hairGrowth":{
           "type":"linearGrowth",
           "t1":"hairGrowthStart",
           "W1":"heavisideTransition",
           "t2":"hairGrowthStop",
           "W2":"heavisideTransition",
           "C":"hairVolumeMax"}},
    "derivedParameters":{
       "hairVolumeMax":{
           "type":"product",
           "a":"hairVolumeFraction",
           "b":"bodyWeight"},
        "hairGrowthStop":{
           "type":"sum",
           "a":"hairGrowthStart",
           "b":"hairGrowthDuration"},
        "hairGrowthDuration":{
            "type":"ratio",
            "a":"hairVolumeMax",
            "b":"hairGrowth"},
        "hairGrowth":{
            "type":"ratio",
            "a":"kH",
            "b":"hairPC"},
       "bwPower0p75":{
          "type":"power",
          "a":"bodyWeight",
          "n":"threeQuarters"},
       "plasmaFlow":{
          "type":"product",
          "a":"plasmaFlowScaled",
          "b":"bodyWeight0p75"},
       "hairPC":{
          "type":"ratio",
          "a":"hairPCBlood",
          "b":"slowlyPerfusedPC"}}
}