PBPK_public/models/cDiazepam.json

{
   "timeUnit":"min",
   "compartments":["adipose","brain","heart","kidney","liver",
      "splanchnic","stomach","muscle","skin","testes","remainder","lung",
      "excrement","arterial","venous"],
   "commentScaled":"add compartments that only have inputs so they can be scaled to total input",
   "scaled":["excrement"],
   "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
   "volumeComment":"in a compartment w/o volume, value is mass",
   "volumes":{
      "adipose":"adiposeVolume",
      "brain":"brainVolume",
      "heart":"heartVolume",
      "kidney":"kidneyVolume",
      "liver":"liverVolume",
      "lung":"lungVolume",
      "muscle":"muscleVolume",
      "skin":"skinVolume",
      "splanchnic":"splanchnicVolume",
      "stomach":"stomachVolume",
      "testes":"testesVolume",
      "remainder":"remainderVolume",
      "venous":"venousVolume",
      "arterial":"arterialVolume"},
   "flows":{
      "(arterial,venous):adipose":"adiposeFlow",
      "(arterial,venous):brain":"brainFlow",
      "(arterial,venous):heart":"heartFlow",
      "(arterial,venous):kidney":"kidneyFlow",
      "arterial:liver":"liverInFlow",
      "liver:venous":"liverOutFlow",
      "(arterial,venous):lung":"totalFlow",
      "(arterial,venous):muscle":"muscleFlow",
      "(arterial,venous):skin":"skinFlow",
      "(arterial,liver):splanchnic":"splanchnicFlow",
      "(arterial,liver):stomach":"stomachFlow",
      "(arterial,venous):testes":"testesFlow",
      "(arterial,venous):remainder":"remainderFlow"},
   "commentSources":"constants in concentration units per s",
   "commentHeavyside":"value is mass of exogene/volume of container/duration",
   "inputs":{
      "venous":"venousInput"},
   "commentBindings":"split to flow and diffusion dominated",
   "bindings": {
      "flowComments":"group common sources or targets with brackets",
      "flow":[
         "(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder)->venous",
         "(splanchnic,stomach)->liver",
         "arterial->(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder,splanchnic,stomach)",
         "venous->lung",
         "lung->arterial"],
      "diffusion":{
         "liver->excrement":"k1"}},
    "pcComments":"always related to outflow of organs", 
    "partitionCoefficients":{
       "adipose":"adiposePC",
       "brain":"brainPC",
       "heart":"heartPC",
       "kidney":"kidneyPC",
       "liver":"liverPC",
       "lung":"lungPC",
       "muscle":"musclePC",
       "remainder":"remainderPC",
       "skin":"skinPC",
       "splanchnic":"splanchnicPC",
       "stomach":"stomachPC",
       "testes":"testesPC"}
}