PBPK_public/models/cDiazepam_parameters1.json

{
     "parameters":{
        "commentsInput":"X",
        "venousInput":{"value":0.3e6,"commentUnit":"sameUnitAsVolumes"},
        "_venousInput":{"function":"venousInput"},
        "inputA":{"value":0.01,"commentUnit":"sameAsVolumes"},
        "inputTau":{"value":1,"commentUnit":"sameAsTimeUnit"},
        "commentPC":"X",
        "adiposePC":{"value":23.1,"dist":"lognormal","cv":0.3},
	     "brainPC":{"value":2.2,"dist":"lognormal","cv":0.3},
	     "heartPC":{"value":4.3},
        "kidneyPC":{"value":5.2},
	     "liverPC":{"value":9.1},
	     "lungPC":{"value":5.3},
	     "musclePC":{"value":2.4},
        "remainderPC":{"value":16.5},
        "skinPC":{"value":3.2,"dist":"lognormal","cv":0.3},
	     "splanchnicPC":{"value":4.3},
	     "stomachPC":{"value":4.5},
	     "testesPC":{"value":4.7},
        "commentFlows":"X",
        "flowNotes":"liverOutFlow is sum of liver,splanchnic and stomach",
        "adiposeFlow":{"value":2.55,"unit":"ml/min"},
        "brainFlow":{"value":0.78,"unit":"ml/min"},
        "heartFlow":{"value":4.2,"unit":"ml/min"},
        "kidneyFlow":{"value":16.61,"unit":"ml/min"},
        "liverInFlow":{"value":3.55,"unit":"ml/min"},
        "liverOutFlow":{"derived":"liverOutFlow"},
        "gutOutFlow":{"derived":"gutOutFlow"},
        "totalFlow":{"value":80,"unit":"ml/min"},
        "muscleFlow":{"value":16.25,"unit":"ml/min"},
        "skinFlow":{"value":7.1,"unit":"ml/min"},
        "splanchnicFlow":{"value":20.25,"unit":"ml/min"},
        "stomachFlow":{"value":1.9,"unit":"ml/min"},
        "testesFlow":{"value":1.9,"unit":"ml/min"},
        "remainderFlow":{"value":4.91,"unit":"ml/min"},
        "adiposeVolume":{"value":10,"unit":"g"},
        "brainVolume":{"value":1.2,"unit":"g"},
        "heartVolume":{"value":1,"unit":"g"},
        "kidneyVolume":{"value":2,"unit":"g"},
        "liverVolume":{"value":11,"unit":"g"},
        "lungVolume":{"value":1.2,"unit":"g"},
        "muscleVolume":{"value":125,"unit":"g"},
        "skinVolume":{"value":43.8,"unit":"g"},
        "splanchnicVolume":{"value":15,"unit":"g"},
        "stomachVolume":{"value":1.1,"unit":"g"},
        "testesVolume":{"value":2.5,"unit":"g"},
        "remainderVolume":{"value":15.8,"unit":"g"},
        "venousVolume":{"value":13.6,"unit":"g"},
        "arterialVolume":{"value":6.8,"unit":"g"},
        "liverToExcrementNotes":"CL=422 ml/min,PC=9.1,f=0.15,V=11g->k1=0.0105/s",
        "k1":{"value":0.0105,"unit":"1/s"}},
   "derivedParameters":{
      "liverOutFlow":{
         "type":"sum",
         "a":"liverInFlow",
         "b":"gutOutFlow"},
      "gutOutFlow":{
         "type":"sum",
         "a":"splanchnicFlow",
         "b":"stomachFlow"}
   },
   "functions":{
      "venousInput":{"type":"exp","A":"inputA","tau":"inputTau"}
   }

}