PBPK_public/models/humanHG_parameters1.json

{"parameters":{
        "bodyWeight":{"value":67.77,"units":"kg","dist":"lognormal","cv":0.26},
        "bwPower0p75":{"derived":"bwPower0p75"},
        "commentPC":"X",
        "brainBloodPC":{"value":1,"dist":"lognormal","cv":0.3},
        "brainPC":{"value":3,"dist":"lognormal","cv":0.3},
        "fatPC":{"value":0.15,"dist":"lognormal","cv":0.3},
        "gutPC":{"value":1,"dist":"lognormal","cv":0.7},
        "hairPC":{"derived":"hairPC"},
        "hairPCBlood":{"value":248.7,"dist":"lognormal","cv":0.7},
        "kidneyPC":{"value":4.0,"dist":"lognormal","cv":0.3},
        "liverPC":{"value":5.0,"dist":"lognormal","cv":0.3},
        "rbcPC":{"value":12.0,"dist":"lognormal","cv":0.3},
        "richlyPerfusedPC":{"value":1.0,"dist":"lognormal","cv":0.3},
        "slowlyPerfusedPC":{"value":2.0,"dist":"lognormal","cv":0.3},
        "commentCardiacOutput":"X",
        "cardiacOutput":{"derived":"cardiacOutput"},
        "cardiacOutputScaled":{"value":0.333,"unit":"l/min","dist":"normal","cv":0.22},
        "commentFlows":"X",
        "plasmaFlow":{"derived":"plasmaFlow"},
        "kidneyFlow":{"derived":"kidneyFlow"},
        "richlyPerfusedFlow":{"derived":"richlyPerfusedFlow"},
        "fatFlow":{"derived":"fatFlow"},
        "slowlyPerfusedFlow":{"derived":"slowlyPerfusedFlow"},
        "brainBloodFlow":{"derived":"brainBloodFlow"},
        "liverInFlow":{"derived":"liverInFlow"},
        "liverOutFlow":{"derived":"liverOutFlow"},
        "gutFlow":{"derived":"gutFlow"},
        "commentFlowFraction":"X",
        "plasmaFlowFraction":{"value":1},
        "kidneyFlowFraction":{"value":0.175,"dist":"normal","cv":0.3},
        "richlyPerfusedFlowFraction":{"value":0.183,"dist":"normal","cv":0.3},
        "fatFlowFraction":{"value":0.052,"dist":"normal","cv":0.3},
        "slowlyPerfusedFlowFraction":{"value":0.249,"dist":"normal","cv":0.3},
        "brainBloodFlowFraction":{"value":0.114,"dist":"normal","cv":0.3},
        "liverInFlowFraction":{"value":0.046,"dist":"normal","cv":0.32},
        "commentLiverOutFlow":"sum of liver in and gut",
        "liverOutFlowFraction":{"value":0.227,"dist":"normal","cv":0.3},
        "gutFlowFraction":{"value":0.181,"dist":"normal","cv":0.33},
        "commentVolumes":"X",
        "plasmaVolume":{"derived":"plasmaVolume"},
        "redBloodCellsVolume":{"derived":"redBloodCellsVolume"},
        "kidneyVolume":{"derived":"kidneyVolume"},
        "richlyPerfusedVolume":{"derived":"richlyPerfusedVolume"},
        "fatVolume":{"derived":"fatVolume"},
        "hairVolume":{"function":"hairGrowth"},
        "hairGrowthDuration":{"derived":"hairGrowthDuration"},
        "hairVolumeMax":{"derived":"hairVolumeMax"},
        "slowlyPerfusedVolume":{"derived":"slowlyPerfusedVolume"},
        "brainBloodVolume":{"derived":"brainBloodVolume"},
        "brainVolume":{"derived":"brainVolume"},
        "liverVolume":{"derived":"liverVolume"},
        "gutVolume":{"derived":"gutVolume"},
        "intestineVolume":{"derived":"intestineVolume"},
        "commentFractions":"X",
        "plasmaVolumeFraction":{"value":0.024,"dist":"normal","cv":0.14},
        "redBloodCellsVolumeFraction":{"value":0.024,"dist":"normal","cv":0.25},
        "kidneyVolumeFraction":{"value":0.004,"dist":"normal","cv":0.3},
        "richlyPerfusedVolumeFraction":{"value":0.1,"dist":"normal","cv":0.3},
        "fatVolumeFraction":{"value":0.273,"dist":"normal","cv":0.24},
        "hairVolumeFraction":{"value":0.002,"dist":"normal","cv":0.5},
        "slowlyPerfusedVolumeFraction":{"value":0.35,"dist":"normal","cv":0.16},
        "brainBloodVolumeFraction":{"value":0.007,"dist":"normal","cv":0.3},
        "brainVolumeFraction":{"value":0.02,"dist":"normal","cv":0.3},
        "liverVolumeFraction":{"value":0.026,"dist":"normal","cv":0.25},
        "gutVolumeFraction":{"value":0.017,"dist":"normal","cv":0.15},
        "intestineVolumeFraction":{"value":0.14,"dist":"normal","cv":0.3},
        "commentDiff":"X",
        "kB":{"derived":"kB"},
        "kBR":{"derived":"kBR"},
        "kD":{"derived":"kD"},
        "kF":{"derived":"kF"},
        "kH":{"derived":"kH"},
        "kI":{"derived":"kI"},
        "kIF":{"derived":"kIF"},
        "kRBC":{"derived":"kRBC"},
        "kR":{"derived":"kR"},
        "kU":{"derived":"kU"},
        "commentDiffScaled":"X",
        "kBScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
        "kBRScaled":{"value":1.67e-4,"unit":"l/min","dist":"lognormal","cv":0.3},
        "kDScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
        "kFScaled":{"value":3.33e-6,"unit":"l/min","dist":"lognormal","cv":0.36},
        "kHScaled":{"value":1.17e-7,"unit":"l/min","dist":"lognormal","cv":0.25},
        "kIScaled":{"value":1.67e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
        "kIFScaled":{"value":0,"unit":"l/min","noDist":"lognormal","cv":0.3},
        "kRBCScaled":{"value":2.5e-2,"unit":"l/min","dist":"lognormal","cv":0.3},
        "kRScaled":{"value":8.33e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
        "kUScaled":{"value":0,"unit":"l/min"},
        "zero":{"value":0},
        "threeQuarters":{"value":0.75},
        "heavisideTransition":{"value":100},
        "hairGrowthStart":{"value":0e6,"unit":"min"},
        "hairGrowthStop":{"derived":"hairGrowthStop"},
        "hairGrowth":{"derived":"hairGrowth"}},
    "functions":{
       "commentHairGrowth":"2yr hair growth to a total mass of 140g",
       "hairGrowth":{
           "type":"linearGrowth",
           "t1":"hairGrowthStart",
           "W1":"heavisideTransition",
           "t2":"hairGrowthStop",
           "W2":"heavisideTransition",
           "C":"hairVolumeMax"}},
    "derivedParameters":{
       "bwPower0p75":{
          "type":"power",
          "a":"bodyWeight",
          "n":"threeQuarters"},
       "cardiacOutput":{
          "type":"product",
          "a":"cardiacOutputScaled",
          "b":"bwPower0p75"},
        "plasmaFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"plasmaFlowFraction"},
        "kidneyFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"kidneyFlowFraction"},
        "richlyPerfusedFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"richlyPerfusedFlowFraction"},
        "fatFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"fatFlowFraction"},
        "slowlyPerfusedFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"slowlyPerfusedFlowFraction"},
        "brainBloodFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"brainBloodFlowFraction"},
        "liverInFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"liverInFlowFraction"},
        "liverOutFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"liverOutFlowFraction"},
        "gutFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"gutFlowFraction"},
        "plasmaVolume":{
           "type":"product",
           "a":"plasmaVolumeFraction",
           "b":"bodyWeight"},
        "redBloodCellsVolume":{
           "type":"product",
           "a":"redBloodCellsVolumeFraction",
           "b":"bodyWeight"},
        "kidneyVolume":{
           "type":"product",
           "a":"kidneyVolumeFraction",
           "b":"bodyWeight"},
        "richlyPerfusedVolume":{
           "type":"product",
           "a":"richlyPerfusedVolumeFraction",
           "b":"bodyWeight"},
        "fatVolume":{
           "type":"product",
           "a":"fatVolumeFraction",
           "b":"bodyWeight"},
        "slowlyPerfusedVolume":{
           "type":"product",
           "a":"slowlyPerfusedVolumeFraction",
           "b":"bodyWeight"},
        "brainBloodVolume":{
           "type":"product",
           "a":"brainBloodVolumeFraction",
           "b":"bodyWeight"},
        "brainVolume":{
           "type":"product",
           "a":"brainVolumeFraction",
           "b":"bodyWeight"},
        "liverVolume":{
           "type":"product",
           "a":"liverVolumeFraction",
           "b":"bodyWeight"},
        "gutVolume":{
           "type":"product",
           "a":"gutVolumeFraction",
           "b":"bodyWeight"},
        "intestineVolume":{
           "type":"product",
           "a":"intestineVolumeFraction",
           "b":"bodyWeight"},
       "hairVolumeMax":{
           "type":"product",
           "a":"hairVolumeFraction",
           "b":"bodyWeight"},
       "hairGrowthStop":{
           "type":"sum",
           "a":"hairGrowthStart",
           "b":"hairGrowthDuration"},
       "hairGrowthDuration":{
            "type":"ratio",
            "a":"hairVolumeMax",
            "b":"hairGrowth"},
       "hairGrowth":{
            "type":"ratio",
            "a":"kH",
            "b":"hairPC"},
       "hairPC":{
          "type":"ratio",
          "a":"hairPCBlood",
          "b":"slowlyPerfusedPC"},
       "kB":{
          "type":"product",
          "a":"kBScaled",
          "b":"bwPower0p75"},
       "kBR":{
          "type":"product",
          "a":"kBRScaled",
          "b":"bwPower0p75"},
       "kD":{
          "type":"product",
          "a":"kDScaled",
          "b":"bwPower0p75"},
       "kF":{
          "type":"product",
          "a":"kFScaled",
          "b":"bwPower0p75"},
       "kH":{
          "type":"product",
          "a":"kHScaled",
          "b":"bwPower0p75"},
       "kI":{
          "type":"product",
          "a":"kIScaled",
          "b":"bwPower0p75"},
       "kIF":{
          "type":"product",
          "a":"kIFScaled",
          "b":"bwPower0p75"},
       "kRBC":{
          "type":"product",
          "a":"kRBCScaled",
          "b":"bwPower0p75"},
       "kR":{
          "type":"product",
          "a":"kRScaled",
          "b":"bwPower0p75"},
       "kU":{
          "type":"product",
          "a":"kUScaled",
          "b":"bwPower0p75"}}
}