humanHG_parameters1.json 8.5 KB

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  1. {"parameters":{
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  3. "bwPower0p75":{"derived":"bwPower0p75"},
  4. "commentPC":"X",
  5. "brainBloodPC":{"value":1,"dist":"lognormal","cv":0.3},
  6. "brainPC":{"value":3,"dist":"lognormal","cv":0.3},
  7. "fatPC":{"value":0.15,"dist":"lognormal","cv":0.3},
  8. "gutPC":{"value":1,"dist":"lognormal","cv":0.7},
  9. "kidneyPC":{"value":4.0,"dist":"lognormal","cv":0.3},
  10. "liverPC":{"value":5.0,"dist":"lognormal","cv":0.3},
  11. "rbcPC":{"value":12.0,"dist":"lognormal","cv":0.3},
  12. "richlyPerfusedPC":{"value":1.0,"dist":"lognormal","cv":0.3},
  13. "slowlyPerfusedPC":{"value":2.0,"dist":"lognormal","cv":0.3},
  14. "commentCardiacOutput":"X",
  15. "cardiacOutput":{"derived":"cardiacOutput"},
  16. "cardiacOutputScaled":{"value":0.333,"unit":"l/min","dist":"normal","cv":0.22},
  17. "commentFlows":"X",
  18. "plasmaFlow":{"derived":"plasmaFlow"},
  19. "kidneyFlow":{"derived":"kidneyFlow"},
  20. "richlyPerfusedFlow":{"derived":"richlyPerfusedFlow"},
  21. "fatFlow":{"derived":"fatFlow"},
  22. "slowlyPerfusedFlow":{"derived":"slowlyPerfusedFlow"},
  23. "brainBloodFlow":{"derived":"brainBloodFlow"},
  24. "liverInFlow":{"derived":"liverInFlow"},
  25. "liverOutFlow":{"derived":"liverOutFlow"},
  26. "gutFlow":{"derived":"gutFlow"},
  27. "commentFlowFraction":"X",
  28. "plasmaFlowFraction":{"value":1},
  29. "kidneyFlowFraction":{"value":0.175,"dist":"normal","cv":0.3},
  30. "richlyPerfusedFlowFraction":{"value":0.183,"dist":"normal","cv":0.3},
  31. "fatFlowFraction":{"value":0.052,"dist":"normal","cv":0.3},
  32. "slowlyPerfusedFlowFraction":{"value":0.249,"dist":"normal","cv":0.3},
  33. "brainBloodFlowFraction":{"value":0.114,"dist":"normal","cv":0.3},
  34. "liverInFlowFraction":{"value":0.046,"dist":"normal","cv":0.32},
  35. "commentLiverOutFlow":"sum of liver in and gut",
  36. "liverOutFlowFraction":{"value":0.227,"dist":"normal","cv":0.3},
  37. "gutFlowFraction":{"value":0.181,"dist":"normal","cv":0.33},
  38. "commentVolumes":"X",
  39. "plasmaVolume":{"derived":"plasmaVolume"},
  40. "redBloodCellsVolume":{"derived":"redBloodCellsVolume"},
  41. "kidneyVolume":{"derived":"kidneyVolume"},
  42. "richlyPerfusedVolume":{"derived":"richlyPerfusedVolume"},
  43. "fatVolume":{"derived":"fatVolume"},
  44. "hairVolume":{"value":1},
  45. "slowlyPerfusedVolume":{"derived":"slowlyPerfusedVolume"},
  46. "brainBloodVolume":{"derived":"brainBloodVolume"},
  47. "brainVolume":{"derived":"brainVolume"},
  48. "liverVolume":{"derived":"liverVolume"},
  49. "gutVolume":{"derived":"gutVolume"},
  50. "intestineVolume":{"derived":"intestineVolume"},
  51. "commentFractions":"X",
  52. "plasmaVolumeFraction":{"value":0.024,"dist":"normal","cv":0.14},
  53. "redBloodCellsVolumeFraction":{"value":0.024,"dist":"normal","cv":0.25},
  54. "kidneyVolumeFraction":{"value":0.004,"dist":"normal","cv":0.3},
  55. "richlyPerfusedVolumeFraction":{"value":0.1,"dist":"normal","cv":0.3},
  56. "fatVolumeFraction":{"value":0.273,"dist":"normal","cv":0.24},
  57. "hairVolumeFraction":{"value":0.002,"dist":"normal","cv":0.5},
  58. "slowlyPerfusedVolumeFraction":{"value":0.35,"dist":"normal","cv":0.16},
  59. "brainBloodVolumeFraction":{"value":0.007,"dist":"normal","cv":0.3},
  60. "brainVolumeFraction":{"value":0.02,"dist":"normal","cv":0.3},
  61. "liverVolumeFraction":{"value":0.026,"dist":"normal","cv":0.25},
  62. "gutVolumeFraction":{"value":0.017,"dist":"normal","cv":0.15},
  63. "intestineVolumeFraction":{"value":0.14,"dist":"normal","cv":0.3},
  64. "commentDiff":"X",
  65. "kB":{"derived":"kB"},
  66. "kBR":{"derived":"kBR"},
  67. "kD":{"derived":"kD"},
  68. "kF":{"derived":"kF"},
  69. "kH":{"derived":"kH"},
  70. "kI":{"derived":"kI"},
  71. "kIF":{"derived":"kIF"},
  72. "kRBC":{"derived":"kRBC"},
  73. "kR":{"derived":"kR"},
  74. "kU":{"derived":"kU"},
  75. "commentDiffScaled":"X",
  76. "kBScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
  77. "kBRScaled":{"value":1.67e-4,"unit":"l/min","dist":"lognormal","cv":0.3},
  78. "kDScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
  79. "kFScaled":{"value":3.33e-6,"unit":"l/min","dist":"lognormal","cv":0.36},
  80. "kHScaled":{"value":1.17e-7,"unit":"l/min","dist":"lognormal","cv":0.25},
  81. "kIScaled":{"value":1.67e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
  82. "kIFScaled":{"value":0,"unit":"l/min","noDist":"lognormal","cv":0.3},
  83. "kRBCScaled":{"value":2.5e-2,"unit":"l/min","dist":"lognormal","cv":0.3},
  84. "kRScaled":{"value":8.33e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
  85. "kUScaled":{"value":0,"unit":"l/min"},
  86. "zero":{"value":0},
  87. "threeQuarters":{"value":0.75}},
  88. "derivedParameters":{
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  91. "a":"bodyWeight",
  92. "n":"threeQuarters"},
  93. "cardiacOutput":{
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  95. "a":"cardiacOutputScaled",
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  97. "plasmaFlow":{
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  99. "a":"cardiacOutput",
  100. "b":"plasmaFlowFraction"},
  101. "kidneyFlow":{
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  103. "a":"cardiacOutput",
  104. "b":"kidneyFlowFraction"},
  105. "richlyPerfusedFlow":{
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  108. "b":"richlyPerfusedFlowFraction"},
  109. "fatFlow":{
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  111. "a":"cardiacOutput",
  112. "b":"fatFlowFraction"},
  113. "slowlyPerfusedFlow":{
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  115. "a":"cardiacOutput",
  116. "b":"slowlyPerfusedFlowFraction"},
  117. "brainBloodFlow":{
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  119. "a":"cardiacOutput",
  120. "b":"brainBloodFlowFraction"},
  121. "liverInFlow":{
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  124. "b":"liverInFlowFraction"},
  125. "liverOutFlow":{
  126. "type":"product",
  127. "a":"cardiacOutput",
  128. "b":"liverOutFlowFraction"},
  129. "gutFlow":{
  130. "type":"product",
  131. "a":"cardiacOutput",
  132. "b":"gutFlowFraction"},
  133. "plasmaVolume":{
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  136. "b":"bodyWeight"},
  137. "redBloodCellsVolume":{
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  140. "b":"bodyWeight"},
  141. "kidneyVolume":{
  142. "type":"product",
  143. "a":"kidneyVolumeFraction",
  144. "b":"bodyWeight"},
  145. "richlyPerfusedVolume":{
  146. "type":"product",
  147. "a":"richlyPerfusedVolumeFraction",
  148. "b":"bodyWeight"},
  149. "fatVolume":{
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  152. "b":"bodyWeight"},
  153. "slowlyPerfusedVolume":{
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  155. "a":"slowlyPerfusedVolumeFraction",
  156. "b":"bodyWeight"},
  157. "brainBloodVolume":{
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  159. "a":"brainBloodVolumeFraction",
  160. "b":"bodyWeight"},
  161. "brainVolume":{
  162. "type":"product",
  163. "a":"brainVolumeFraction",
  164. "b":"bodyWeight"},
  165. "liverVolume":{
  166. "type":"product",
  167. "a":"liverVolumeFraction",
  168. "b":"bodyWeight"},
  169. "gutVolume":{
  170. "type":"product",
  171. "a":"gutVolumeFraction",
  172. "b":"bodyWeight"},
  173. "intestineVolume":{
  174. "type":"product",
  175. "a":"intestineVolumeFraction",
  176. "b":"bodyWeight"},
  177. "kB":{
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  180. "b":"bwPower0p75"},
  181. "kBR":{
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  183. "a":"kBRScaled",
  184. "b":"bwPower0p75"},
  185. "kD":{
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  187. "a":"kDScaled",
  188. "b":"bwPower0p75"},
  189. "kF":{
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  191. "a":"kFScaled",
  192. "b":"bwPower0p75"},
  193. "kH":{
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  197. "kI":{
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  199. "a":"kIScaled",
  200. "b":"bwPower0p75"},
  201. "kIF":{
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  203. "a":"kIFScaled",
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  205. "kRBC":{
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  207. "a":"kRBCScaled",
  208. "b":"bwPower0p75"},
  209. "kR":{
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  213. "kU":{
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  217. }