PBPK_public/models/humanHG_parameters3.json

{"parameters":{
        "bodyWeight":{"value":70,"units":"kg"},
        "bodyWeight0p75":{"derived":"bwPower0p75"},
        "kidneyPC":{"value":4.0},
        "richlyPerfusedPC":{"value":1},
        "fatPC":{"value":0.15},
        "slowlyPerfusedPC":{"value":2},
        "brainBloodPC":{"value":1},
        "brainPC":{"value":3},
        "hairPCBlood":{"value":248.7,"dist":"lognormal","cv":0.7},
        "hairPC":{"derived":"hairPC"},
        "placentaPC":{"value":2},
	     "liverPC":{"value":5},
        "gutPC":{"value":1},
        "rbcPC":{"value":12},
        "flowNotes":"assuming 70kg individual, fetus at 0.1kg",
        "plasmaFlow":{"value":8.067,"unit":"l/min"},
        "plasmaFlowScaled":{"value":0.333,"unit":"l/min"},
        "kidneyFlow":{"value":1.412,"unit":"l/min"},
        "richlyPerfusedFlow":{"value":1.484,"unit":"l/min"},
        "fatFlow":{"value":0.419,"unit":"l/min"},
        "slowlyPerfusedFlow":{"value":2.01,"unit":"l/min"},
        "brainBloodFlow":{"value":0.920,"unit":"l/min"},
        "placentaFlow":{"value":0.173,"unit":"l/min"},
        "liverInFlow":{"value":0.391,"unit":"l/min"},
        "liverOutFlow":{"value":1.928,"unit":"l/min"},
        "gutFlow":{"value":1.538,"unit":"l/min"},
        "commentVolumes":"X",
        "plasmaVolume":{"derived":"plasmaVolume"},
        "redBloodCellsVolume":{"derived":"redBloodCellsVolume"},
        "kidneyVolume":{"derived":"kidneyVolume"},
        "richlyPerfusedVolume":{"derived":"richlyPerfusedVolume"},
        "fatVolume":{"derived":"fatVolume"},
        "hairVolume":{"function":"hairGrowth"},
        "hairGrowthDuration":{"derived":"hairGrowthDuration"},
        "hairVolumeMax":{"derived":"hairVolumeMax"},
        "slowlyPerfusedVolume":{"derived":"slowlyPerfusedVolume"},
        "brainBloodVolume":{"derived":"brainBloodVolume"},
        "brainVolume":{"derived":"brainVolume"},
        "liverVolume":{"derived":"liverVolume"},
        "gutVolume":{"derived":"gutVolume"},
        "intestineVolume":{"derived":"intestineVolume"},
        "placentaVolume":{"derived":"placentaVolume"},
        "fetusWeight":{"function":"fetusWeight"},
        "fetusWeightMax":{"value":4.0,"unit":"kg","dist":"normal","cv":0.1},
        "commentFractions":"X",
        "plasmaVolumeFraction":{"value":0.024,"dist":"normal","cv":0.14},
        "redBloodCellsVolumeFraction":{"value":0.024,"dist":"normal","cv":0.25},
        "kidneyVolumeFraction":{"value":0.004,"dist":"normal","cv":0.3},
        "richlyPerfusedVolumeFraction":{"value":0.1,"dist":"normal","cv":0.3},
        "fatVolumeFraction":{"value":0.273,"dist":"normal","cv":0.24},
        "hairVolumeFraction":{"value":0.002,"dist":"normal","cv":0.5},
        "slowlyPerfusedVolumeFraction":{"value":0.35,"dist":"normal","cv":0.16},
        "brainBloodVolumeFraction":{"value":0.007,"dist":"normal","cv":0.3},
        "brainVolumeFraction":{"value":0.02,"dist":"normal","cv":0.3},
        "liverVolumeFraction":{"value":0.026,"dist":"normal","cv":0.25},
        "placentaVolumeFraction":{"value":0.18,"dist":"normal","cv":0.13},
        "placentaVolumeFractionSurce":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530253",
        "gutVolumeFraction":{"value":0.017,"dist":"normal","cv":0.15},
        "intestineVolumeFraction":{"value":0.14,"dist":"normal","cv":0.3},
        "commentDiff":"X",
        "kRBC":{"value":0.60,"unit":"l/min"},
        "kU":{"value":0,"unit":"l/min"},
        "commentkH":"assume pc-times larger input flow, 2.823e-6*248.7",
        "kH":{"value":2.823e-6,"unit":"l/min"},
        "kBR":{"value":4.033e-3,"unit":"l/min"},
        "kI":{"value":4.033e-6,"unit":"l/min"},
        "kB":{"value":4.033e-5,"unit":"l/min"},
        "kD":{"value":4.033e-5,"unit":"l/min"},
        "kF":{"value":8.066e-5,"unit":"l/min"},
        "kF1":{"value":0,"unit":"l/min"},
        "kR":{"value":2.016e-3,"unit":"l/min"},
        "zero":{"value":0},
        "threeQuarters":{"value":0.75},
        "heavisideTransition":{"value":100},
        "hairGrowthStart":{"value":0e6,"unit":"min"},
        "hairGrowthStop":{"derived":"hairGrowthStop"},
        "hairGrowth":{"derived":"hairGrowth"},
        "fetusGrowthStart":{"value":8.6e5,"unit":"min"},
        "fetusGrowthDuration":{"value":4e5,"unit":"min"},
        "fetusGrowthStop":{"derived":"fetusGrowthStop"}},
    "functions":{
       "commentHairGrowth":"2yr hair growth to a total mass of 140g",
       "hairGrowth":{
           "type":"linearGrowth",
           "t1":"hairGrowthStart",
           "W1":"heavisideTransition",
           "t2":"hairGrowthStop",
           "W2":"heavisideTransition",
           "C":"hairVolumeMax"},
       "fetusWeight":{
           "type":"linearGrowth",
           "t1":"fetusGrowthStart",
           "t2":"fetusGrowthStop",
           "W1":"heavisideTransition",
           "W2":"heavisideTransition",
           "C":"fetusWeightMax"}},
    "derivedParameters":{
        "plasmaVolume":{
           "type":"product",
           "a":"plasmaVolumeFraction",
           "b":"bodyWeight"},
        "redBloodCellsVolume":{
           "type":"product",
           "a":"redBloodCellsVolumeFraction",
           "b":"bodyWeight"},
        "kidneyVolume":{
           "type":"product",
           "a":"kidneyVolumeFraction",
           "b":"bodyWeight"},
        "richlyPerfusedVolume":{
           "type":"product",
           "a":"richlyPerfusedVolumeFraction",
           "b":"bodyWeight"},
        "fatVolume":{
           "type":"product",
           "a":"fatVolumeFraction",
           "b":"bodyWeight"},
        "slowlyPerfusedVolume":{
           "type":"product",
           "a":"slowlyPerfusedVolumeFraction",
           "b":"bodyWeight"},
        "brainBloodVolume":{
           "type":"product",
           "a":"brainBloodVolumeFraction",
           "b":"bodyWeight"},
        "brainVolume":{
           "type":"product",
           "a":"brainVolumeFraction",
           "b":"bodyWeight"},
        "liverVolume":{
           "type":"product",
           "a":"liverVolumeFraction",
           "b":"bodyWeight"},
        "gutVolume":{
           "type":"product",
           "a":"gutVolumeFraction",
           "b":"bodyWeight"},
        "intestineVolume":{
           "type":"product",
           "a":"intestineVolumeFraction",
           "b":"bodyWeight"},
        "placentaVolume":{
           "type":"product",
           "a":"placentaVolumeFraction",
           "b":"fetusWeight"},
       "hairVolumeMax":{
           "type":"product",
           "a":"hairVolumeFraction",
           "b":"bodyWeight"},
        "hairGrowthStop":{
           "type":"sum",
           "a":"hairGrowthStart",
           "b":"hairGrowthDuration"},
        "hairGrowthDuration":{
            "type":"ratio",
            "a":"hairVolumeMax",
            "b":"hairGrowth"},
        "hairGrowth":{
            "type":"ratio",
            "a":"kH",
            "b":"hairPC"},
       "fetusGrowthStop":{
            "type":"sum",
            "a":"fetusGrowthStart",
            "b":"fetusGrowthDuration"},
       "bwPower0p75":{
          "type":"power",
          "a":"bodyWeight",
          "n":"threeQuarters"},
       "plasmaFlow":{
          "type":"product",
          "a":"plasmaFlowScaled",
          "b":"bodyWeight0p75"},
       "hairPC":{
          "type":"ratio",
          "a":"hairPCBlood",
          "b":"slowlyPerfusedPC"}}
}