PBPK_public/models/cCotinine.json

{
   "compartments":["adipose","brain","heart","kidney","liver",
   "splanchnic","stomach","muscle","skin","testes","remainder","lung",
   "excrement","arterial","venous","source"],
   "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
   "volumes":{
      "adipose":"adiposeVolume",
      "brain":"brainVolume",
      "heart":"heartVolume",
      "kidney":"kidneyVolume",
      "liver":"liverVolume",
      "lung":"lungVolume",
      "muscle":"muscleVolume",
      "skin":"skinVolume",
      "splanchnic":"splanchnicVolume",
      "stomach":"stomachVolume",
      "testes":"testesVolume",
      "remainder":"remainderVolume",
      "venous":"venousVolume",
      "arterial":"arterialVolume"},
   "flows":{
      "(arterial,venous):adipose":"adiposeFlow",
      "(arterial,venous):brain":"brainFlow",
      "(arterial,venous):heart":"heartFlow",
      "(arterial,venous):kidney":"kidneyFlow",
      "arterial:liver":"liverInFlow",
      "liver:venous":"liverOutFlow",
      "(arterial,venous):lung":"totalFlow",
      "(arterial,venous):muscle":"muscleFlow",
      "(arterial,venous):skin":"skinFlow",
      "(arterial,liver):splanchnic":"splanchnicFlow",
      "(arterial,liver):stomach":"stomachFlow",
      "(arterial,venous):testes":"testesFlow",
      "(arterial,venous):remainder":"remainderFlow"},
   "commentSources":"constants in concentration units per s",
   "commentHeavyside":"value is mass of exogene/volume of container/duration",
   "sources":{
      "arterial":{"name":"exponential","k":-0.005,"constant":0},
      "venous":{"name":"Heavyside","limit":3,"value":1.22e4}},
   "commentBindings":"split to flow and diffusion dominated",
   "bindings": {
      "flowComments":"group common sources or targets with brackets",
      "flow":[
         "(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder)->venous",
         "(splanchnic,stomach)->liver",
         "arterial->(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder,splanchnic,stomach)",
         "venous->lung",
         "lung->arterial"],
      "diffusion":{
         "liver->excrement":"k1"}},
    "pcComments":"always related to outflow of organs", 
    "partitionCoefficients":{
       "adipose":"adiposePC",
       "brain":"brainPC",
       "heart":"heartPC",
       "kidney":"kidneyPC",
       "liver":"liverPC",
       "lung":"lungPC",
       "muscle":"musclePC",
       "remainder":"remainderPC",
       "skin":"remainderPC",
       "splanchnic":"splanchnicPC",
       "stomach":"stomachPC",
       "testes":"testesPC"},
     "parameters":{
        "adiposePC":{"value":0.04,"dist":"lognormal","cv":0.3},
	     "brainPC":{"value":0.27,"dist":"lognormal","cv":0.3},
	     "heartPC":{"value":0.28},
        "kidneyPC":{"value":0.72},
	     "liverPC":{"value":0.39},
	     "lungPC":{"value":0.3},
	     "musclePC":{"value":0.29},
        "remainderPC":{"value":0.18},
	     "splanchnicPC":{"value":0.31},
	     "stomachPC":{"value":0.18},
	     "testesPC":{"value":0.18},
        "flowNotes":"liverOutFlow is sum of liver,splanchnic and stomach",
        "flowNotes1":"liverOutFlow=3.55+20.25+1.9",
        "adiposeFlow":{"value":2.55,"unit":"ml/min"},
        "brainFlow":{"value":0.78,"unit":"ml/min"},
        "heartFlow":{"value":4.2,"unit":"ml/min"},
        "kidneyFlow":{"value":16.61,"unit":"ml/min"},
        "liverInFlow":{"value":3.55,"unit":"ml/min"},
        "liverOutFlow":{"value":25.7,"unit":"ml/min"},
        "totalFlow":{"value":80,"unit":"ml/min"},
        "muscleFlow":{"value":16.25,"unit":"ml/min"},
        "skinFlow":{"value":7.1,"unit":"ml/min"},
        "splanchnicFlow":{"value":20.25,"unit":"ml/min"},
        "stomachFlow":{"value":1.9,"unit":"ml/min"},
        "testesFlow":{"value":1.9,"unit":"ml/min"},
        "remainderFlow":{"value":4.91,"unit":"ml/min"},
        "adiposeVolume":{"value":10,"unit":"g"},
        "brainVolume":{"value":1.2,"unit":"g"},
        "heartVolume":{"value":1,"unit":"g"},
        "kidneyVolume":{"value":2,"unit":"g"},
        "liverVolume":{"value":11,"unit":"g"},
        "lungVolume":{"value":1.2,"unit":"g"},
        "muscleVolume":{"value":125,"unit":"g"},
        "skinVolume":{"value":43.8,"unit":"g"},
        "splanchnicVolume":{"value":15,"unit":"g"},
        "stomachVolume":{"value":1.1,"unit":"g"},
        "testesVolume":{"value":2.5,"unit":"g"},
        "remainderVolume":{"value":15.8,"unit":"g"},
        "venousVolume":{"value":13.6,"unit":"g"},
        "arterialVolume":{"value":6.8,"unit":"g"},
        "liverToExcrementNotes":"CL=0.13 ml/min,PC=0.39,f=0.97,V=11g->k1=0.00049/s",
        "k1":{"value":0.0049,"unit":"1/s"}}

}