PBPK_public/models/humanHGplusI_parameters.json

{"parameters":{
        "bodyWeight":{"value":67.77,"units":"kg","dist":"lognormal","cv":0.26},
        "bwPower0p75":{"derived":"bwPower0p75"},
        "commentInputs":"X",
        "oralIngestion":{"value":0.0486,"unit":"ug/min"},
        "commentPC":"X",
        "brainBloodPC":{"value":1,"dist":"lognormal","cv":0.3},
        "brainPC":{"value":3,"dist":"lognormal","cv":0.3},
        "fatPC":{"value":0.15,"dist":"lognormal","cv":0.3},
        "gutPC":{"value":1,"dist":"lognormal","cv":0.7},
        "kidneyPC":{"value":4.0,"dist":"lognormal","cv":0.3},
        "liverPC":{"value":5.0,"dist":"lognormal","cv":0.3},
        "rbcPC":{"value":12.0,"dist":"lognormal","cv":0.3},
        "richlyPerfusedPC":{"value":1.0,"dist":"lognormal","cv":0.3},
        "slowlyPerfusedPC":{"value":2.0,"dist":"lognormal","cv":0.3},
        "commentCardiacOutput":"X",
        "cardiacOutput":{"derived":"cardiacOutput"},
        "cardiacOutputScaled":{"value":0.333,"unit":"l/min","dist":"normal","cv":0.22},
        "commentFlows":"X",
        "plasmaFlow":{"derived":"plasmaFlow"},
        "kidneyFlow":{"derived":"kidneyFlow"},
        "richlyPerfusedFlow":{"derived":"richlyPerfusedFlow"},
        "fatFlow":{"derived":"fatFlow"},
        "slowlyPerfusedFlow":{"derived":"slowlyPerfusedFlow"},
        "brainBloodFlow":{"derived":"brainBloodFlow"},
        "liverInFlow":{"derived":"liverInFlow"},
        "liverOutFlow":{"derived":"liverOutFlow"},
        "gutFlow":{"derived":"gutFlow"},
        "commentFlowFraction":"X",
        "plasmaFlowFraction":{"value":1},
        "kidneyFlowFraction":{"value":0.175,"dist":"normal","cv":0.3},
        "richlyPerfusedFlowFraction":{"value":0.183,"dist":"normal","cv":0.3},
        "fatFlowFraction":{"value":0.052,"dist":"normal","cv":0.3},
        "slowlyPerfusedFlowFraction":{"value":0.249,"dist":"normal","cv":0.3},
        "brainBloodFlowFraction":{"value":0.114,"dist":"normal","cv":0.3},
        "liverInFlowFraction":{"value":0.046,"dist":"normal","cv":0.32},
        "commentLiverOutFlow":"sum of liver in and gut",
        "liverOutFlowFraction":{"value":0.227,"dist":"normal","cv":0.3},
        "gutFlowFraction":{"value":0.181,"dist":"normal","cv":0.33},
        "commentVolumes":"X",
        "plasmaVolume":{"derived":"plasmaVolume"},
        "venousVolume":{"derived":"venousVolume"},
        "redBloodCellsVolume":{"derived":"redBloodCellsVolume"},
        "kidneyVolume":{"derived":"kidneyVolume"},
        "richlyPerfusedVolume":{"derived":"richlyPerfusedVolume"},
        "fatVolume":{"derived":"fatVolume"},
        "slowlyPerfusedVolume":{"derived":"slowlyPerfusedVolume"},
        "brainBloodVolume":{"derived":"brainBloodVolume"},
        "brainVolume":{"derived":"brainVolume"},
        "liverVolume":{"derived":"liverVolume"},
        "gutVolume":{"derived":"gutVolume"},
        "intestineVolume":{"derived":"intestineVolume"},
        "commentFractions":"X",
        "plasmaVolumeFraction":{"value":0.012,"dist":"normal","cv":0.14},
        "venousVolumeFraction":{"value":0.012,"dist":"normal","cv":0.14},
        "redBloodCellsVolumeFraction":{"value":0.024,"dist":"normal","cv":0.25},
        "kidneyVolumeFraction":{"value":0.004,"dist":"normal","cv":0.3},
        "richlyPerfusedVolumeFraction":{"value":0.1,"dist":"normal","cv":0.3},
        "fatVolumeFraction":{"value":0.273,"dist":"normal","cv":0.24},
        "hairVolumeFraction":{"value":0.002,"dist":"normal","cv":0.5},
        "slowlyPerfusedVolumeFraction":{"value":0.35,"dist":"normal","cv":0.16},
        "brainBloodVolumeFraction":{"value":0.007,"dist":"normal","cv":0.3},
        "brainVolumeFraction":{"value":0.02,"dist":"normal","cv":0.3},
        "liverVolumeFraction":{"value":0.026,"dist":"normal","cv":0.25},
        "gutVolumeFraction":{"value":0.017,"dist":"normal","cv":0.15},
        "intestineVolumeFraction":{"value":0.014,"dist":"normal","cv":0.3},
        "commentDiff":"X",
        "kB":{"derived":"kB"},
        "kBR":{"derived":"kBR"},
        "kD":{"derived":"kD"},
        "kF":{"derived":"kF"},
        "kH":{"derived":"kH"},
        "kI":{"derived":"kI"},
        "kIF":{"derived":"kIF"},
        "kRBC":{"derived":"kRBC"},
        "kR":{"derived":"kR"},
        "kU":{"derived":"kU"},
        "commentInorganicMercury":"X",
        "dBL":{"derived":"dBL"},
        "dBBr":{"derived":"dBBr"},
        "kLB:I":{"derived":"kLB:I"},
        "kBK:I":{"derived":"kBK:I"},
        "kKB:I":{"derived":"kKB:I"},
        "kKU:I":{"derived":"kKU:I"},
        "kBH:I":{"derived":"kBH:I"},
        "kBU:I":{"derived":"kBU:I"},
        "kBF:I":{"derived":"kBF:I"},
        "kLF:I":{"derived":"kLF:I"},
        "kBBr:I":{"derived":"kBBr:I"},
        "kBrB:I":{"derived":"kBrB:I"},
        "commentDiffScaled":"X",
        "kBScaled":{"value":1.67e-6,"unit":"l/min","dist":"lognormal","cv":0.3},
        "kBRScaled":{"value":1.67e-4,"unit":"l/min","dist":"lognormal","cv":0.3},
        "kDScaled":{"value":1e-4,"unit":"l/hour","dist":"lognormal","cv":0.3},
        "kFScaled":{"value":2e-4,"unit":"l/hour","dist":"lognormal","cv":0.36},
        "kHScaled":{"value":7e-6,"unit":"l/hour","dist":"lognormal","cv":0.25},
        "kIScaled":{"value":1e-5,"unit":"l/hour","dist":"lognormal","cv":0.3},
        "kIFScaled":{"value":0,"unit":"l/min","noDist":"lognormal","cv":0.3},
        "kRBCScaled":{"value":2.5e-2,"unit":"l/min","dist":"lognormal","cv":0.3},
        "kRScaled":{"value":8.33e-5,"unit":"l/min","dist":"lognormal","cv":0.3},
        "kUScaled":{"value":0,"unit":"l/min"},
        "commentInorganicMerucryFromPaper":"X",
        "dBLPaper":{"value":0.175,"unit":"/day","dist":"lognormal","cv":0.3},
        "dBBrPaper":{"value":0.0,"unit":"/day","noDist":"lognormal","cv":0.3},
        "kLB:IPaper":{"value":0.894,"unit":"/day","dist":"lognormal","cv":0.3},
        "kBK:IPaper":{"value":17.1234,"unit":"/day","dist":"lognormal","cv":0.3},
        "kKB:IPaper":{"value":0.001,"unit":"/day","dist":"lognormal","cv":0.3},
        "kKU:IPaper":{"value":0.006949,"unit":"/day","dist":"lognormal","cv":0.3},
        "kBH:IPaper":{"value":0.14,"unit":"/day","dist":"lognormal","cv":0.3},
        "kBU:IPaper":{"value":0.006949,"unit":"/day","dist":"lognormal","cv":0.3},
        "kBF:IPaper":{"value":3.9917,"unit":"/day","dist":"lognormal","cv":0.3},
        "kLF:IPaper":{"value":1.5476,"unit":"/day","dist":"lognormal","cv":0.3},
        "kBBr:IPaper":{"value":0.0028,"unit":"/day","dist":"lognormal","cv":0.3},
        "kBrB:IPaper":{"value":0.052,"unit":"/day","dist":"lognormal","cv":0.3},
        "zero":{"value":0},
        "threeQuarters":{"value":0.75}},
    "derivedParameters":{
       "bwPower0p75":{
          "type":"power",
          "a":"bodyWeight",
          "n":"threeQuarters"},
       "cardiacOutput":{
          "type":"product",
          "a":"cardiacOutputScaled",
          "b":"bwPower0p75"},
        "plasmaFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"plasmaFlowFraction"},
        "kidneyFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"kidneyFlowFraction"},
        "richlyPerfusedFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"richlyPerfusedFlowFraction"},
        "fatFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"fatFlowFraction"},
        "slowlyPerfusedFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"slowlyPerfusedFlowFraction"},
        "brainBloodFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"brainBloodFlowFraction"},
        "liverInFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"liverInFlowFraction"},
        "liverOutFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"liverOutFlowFraction"},
        "gutFlow":{
           "type":"product",
           "a":"cardiacOutput",
           "b":"gutFlowFraction"},
        "plasmaVolume":{
           "type":"product",
           "a":"plasmaVolumeFraction",
           "b":"bodyWeight"},
        "venousVolume":{
           "type":"product",
           "a":"venousVolumeFraction",
           "b":"bodyWeight"},
        "redBloodCellsVolume":{
           "type":"product",
           "a":"redBloodCellsVolumeFraction",
           "b":"bodyWeight"},
        "kidneyVolume":{
           "type":"product",
           "a":"kidneyVolumeFraction",
           "b":"bodyWeight"},
        "richlyPerfusedVolume":{
           "type":"product",
           "a":"richlyPerfusedVolumeFraction",
           "b":"bodyWeight"},
        "fatVolume":{
           "type":"product",
           "a":"fatVolumeFraction",
           "b":"bodyWeight"},
        "slowlyPerfusedVolume":{
           "type":"product",
           "a":"slowlyPerfusedVolumeFraction",
           "b":"bodyWeight"},
        "brainBloodVolume":{
           "type":"product",
           "a":"brainBloodVolumeFraction",
           "b":"bodyWeight"},
        "brainVolume":{
           "type":"product",
           "a":"brainVolumeFraction",
           "b":"bodyWeight"},
        "liverVolume":{
           "type":"product",
           "a":"liverVolumeFraction",
           "b":"bodyWeight"},
        "gutVolume":{
           "type":"product",
           "a":"gutVolumeFraction",
           "b":"bodyWeight"},
        "intestineVolume":{
           "type":"product",
           "a":"intestineVolumeFraction",
           "b":"bodyWeight"},
       "kB":{
          "type":"product",
          "a":"kBScaled",
          "b":"bwPower0p75"},
       "kBR":{
          "type":"product",
          "a":"kBRScaled",
          "b":"bwPower0p75"},
       "kD":{
          "type":"product",
          "a":"kDScaled",
          "b":"bwPower0p75"},
       "kF":{
          "type":"product",
          "a":"kFScaled",
          "b":"bwPower0p75"},
       "kH":{
          "type":"product",
          "a":"kHScaled",
          "b":"bwPower0p75"},
       "kI":{
          "type":"product",
          "a":"kIScaled",
          "b":"bwPower0p75"},
       "kIF":{
          "type":"product",
          "a":"kIFScaled",
          "b":"bwPower0p75"},
       "kRBC":{
          "type":"product",
          "a":"kRBCScaled",
          "b":"bwPower0p75"},
       "kR":{
          "type":"product",
          "a":"kRScaled",
          "b":"bwPower0p75"},
       "kU":{
          "type":"product",
          "a":"kUScaled",
          "b":"bwPower0p75"},
       "dBL":{
          "type":"product",
          "a":"dBLPaper",
          "b":"plasmaVolume"},
       "dBBr":{
          "type":"product",
          "a":"dBBrPaper",
          "b":"plasmaVolume"},
       "kLB:I":{
          "type":"product",
          "a":"kLB:IPaper",
          "b":"liverVolume"},
       "kBK:I":{
          "type":"product",
          "a":"kBK:IPaper",
          "b":"plasmaVolume"},
       "kKB:I":{
          "type":"product",
          "a":"kKB:IPaper",
          "b":"kidneyVolume"},
       "kKU:I":{
          "type":"product",
          "a":"kKU:IPaper",
          "b":"kidneyVolume"},
       "kBH:I":{
          "type":"product",
          "a":"kBH:IPaper",
          "b":"plasmaVolume"},
       "kBU:I":{
          "type":"product",
          "a":"kBU:IPaper",
          "b":"plasmaVolume"},
       "kBF:I":{
          "type":"product",
          "a":"kBF:IPaper",
          "b":"plasmaVolume"},
       "kLF:I":{
          "type":"product",
          "a":"kLF:IPaper",
          "b":"liverVolume"},
       "kBBr:I":{
          "type":"product",
          "a":"kBBr:IPaper",
          "b":"plasmaVolume"},
       "kBrB:I":{
          "type":"product",
          "a":"kBrB:IPaper",
          "b":"brainVolume"}}
}