Переглянути джерело

Adding inital version of human Hg model

Andrej 2 роки тому
батько
коміт
2c8b979174
1 змінених файлів з 112 додано та 0 видалено
  1. 112 0
      models/humanHG.json

+ 112 - 0
models/humanHG.json

@@ -0,0 +1,112 @@
+{
+   "compartments":[
+      "redBloodCells","arterial","venous","kidney","urine",
+      "richlyPerfused","fat","slowlyPerfused","hair",
+      "brainBlood","brain","placenta",
+      "liver","gut","intestine","feces","inorganicMercury"],
+   "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
+   "volumes":{
+      "plasma":"plasmaVolume",
+      "venous":"plasmaVolume",
+      "kidney":"kidneyVolume",
+      "richlyPerfused":"richlyPerfusedVolume",
+      "fat":"fatVolume",
+      "slowlyPerfused":"slowlyPerfusedVolume",
+      "brainBlood":"brainBloodVolume",
+      "placenta":"placentaVolume",
+      "gut":"gutVolume",
+      "intestine":"intestineVolume"},
+   "flows":{
+      "(plasma,venous):kidney":"kidneyFlow",
+      "(plasma,venous):richlyPerfused":"richlyPerfusedFlow",
+      "(plasma,venous):fat":"fatFlow",
+      "(plasma,venous):slowlyPerfused":"slowlyPerfusedFlow",
+      "(plasma,venous):brainBlood":"brainBloodFlow",
+      "(plasma,venous):placenta":"placentaFlow",
+      "plasma:liver":"liverInFlow",
+      "liver:venous":"liverOutFlow",
+      "(plasma,liver):gut":"gutFlow",
+      "plasma:venous":"plasmaFlow"},
+   "commentSources":"constants in concentration units per s",
+   "commentHeavyside":"value is mass of exogene/volume of container/duration",
+   "sources":{
+      "arterial":{"name":"exponential","k":-0.005,"constant":0},
+      "venous":{"name":"Heavyside","limit":3,"value":1.22e4}},
+   "commentBindings":"split to flow and diffusion dominated",
+   "bindings": {
+      "flowComments":"group common sources or targets with brackets",
+      "flow":[
+         "(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver)->venous",
+         "gut->liver",
+         "plasma->(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver,gut)",
+         "venous->plasma"],
+      "diffusion":{
+         "plasma->redBloodCells":"kRBC",
+         "kidney->urine":"kU",
+         "slowlyPerfused->hair":"kH",
+         "brainBlood->brain":"kBR",
+         "liver->intestine":"kB",
+         "liver->inorganicMercury":"kI",
+         "intestine->gut":"kR",
+         "intestine->inorganicMercury":"kD",
+         "intestine->feces":"kF",
+         "inorganicMercury->feces":"kF1"}},
+    "pcComments":"always related to outflow of organs", 
+    "partitionCoefficients":{
+       "kidney":"kidneyPC",
+       "richlyPerfused":"richlyPerfusedPC",
+       "fat":"fatPC",
+       "slowlyPerfused":"slowlyPerfusedPC",
+       "brainBlood":"brainBloodPC",
+       "placenta":"placentaPC",
+       "liver":"liverPC",
+       "gut":"gutPC",
+       "brainBlood->brain":"brainPC",
+       "slowlyPerfused->hair":"hairPC",
+       "plasma->redBloodCells":"rbcPC"},
+     "parameters":{
+        "kidneyPC":{"value":4.0},
+        "richlyPerfusedPC":{"value":1},
+        "fatPC":{"value":0.15},
+        "slowlyPerfusedPC":{"value":2},
+        "brainBloodPC":{"value":1},
+        "brainPC":{"value":3},
+        "hairPC":{"value":248.7},
+        "placentaPC":{"value":2},
+	     "liverPC":{"value":5},
+        "gutPC":{"value":1},
+        "rbcPC":{"value":12},
+        "flowNotes":"assuming 70kg individual, fetus at 0.1kg",
+        "kidneyFlow":{"value":1.412,"unit":"l/min"},
+        "richlyPerfusedFlow":{"value":1.484,"unit":"l/min"},
+        "fatFlow":{"value":0.419,"unit":"l/min"},
+        "slowlyPerfusedFlow":{"value":2.01,"unit":"l/min"},
+        "brainBloodFlow":{"value":0.920,"unit":"l/min"},
+        "placentaFlow":{"value":0.173,"unit":"l/min"},
+        "liverInFlow":{"value":0.391,"unit":"l/min"},
+        "liverOutFlow":{"value":1.928,"unit":"l/min"},
+        "gutFlow":{"value":1.538,"unit":"l/min"},
+        "plasmaVolume":{"value":1.64,"unit":"kg"},
+        "redBloodCellsVolume":{"value":1.64,"unit":"kg"},
+        "kidneyVolume":{"value":0.28,"unit":"kg"},
+        "richlyPerfusedVolume":{"value":7,"unit":"kg"},
+        "fatVolume":{"value":19.11,"unit":"kg"},
+        "hairVolume":{"value":0.14,"unit":"kg"},
+        "slowlyPerfusedVolume":{"value":24.5,"unit":"kg"},
+        "brainBloodVolume":{"value":0.49,"unit":"kg"},
+        "brainVolume":{"value":1.4,"unit":"kg"},
+        "placentaVolume":{"value":0.0431,"unit":"kg"},
+        "liverVolume":{"value":1.82,"unit":"kg"},
+        "gutVolume":{"value":1.19,"unit":"kg"},
+        "intestineVolume":{"value":0.98,"unit":"kg"},
+        "kRBC":{"value":0.025,"unit":"l/min"},
+        "kU":{"value":0,"unit":"l/min"},
+        "kH":{"value":1.167e-7,"unit":"l/min"},
+        "kBR":{"value":1.67e-4,"unit":"l/min"},
+        "kI":{"value":1.67e-7,"unit":"l/min"},
+        "kB":{"value":1.67e-6,"unit":"l/min"},
+        "kD":{"value":1.67e-6,"unit":"l/min"},
+        "kF":{"value":3.33e-6,"unit":"l/min"},
+        "kF1":{"value":0,"unit":"l/min"},
+        "kR":{"value":8.33e-5,"unit":"l/min"}
+}