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@@ -0,0 +1,112 @@
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+{
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+ "compartments":[
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+ "redBloodCells","arterial","venous","kidney","urine",
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+ "richlyPerfused","fat","slowlyPerfused","hair",
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+ "brainBlood","brain","placenta",
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+ "liver","gut","intestine","feces","inorganicMercury"],
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+ "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
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+ "volumes":{
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+ "plasma":"plasmaVolume",
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+ "venous":"plasmaVolume",
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+ "kidney":"kidneyVolume",
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+ "richlyPerfused":"richlyPerfusedVolume",
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+ "fat":"fatVolume",
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+ "slowlyPerfused":"slowlyPerfusedVolume",
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+ "brainBlood":"brainBloodVolume",
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+ "placenta":"placentaVolume",
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+ "gut":"gutVolume",
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+ "intestine":"intestineVolume"},
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+ "flows":{
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+ "(plasma,venous):kidney":"kidneyFlow",
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+ "(plasma,venous):richlyPerfused":"richlyPerfusedFlow",
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+ "(plasma,venous):fat":"fatFlow",
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+ "(plasma,venous):slowlyPerfused":"slowlyPerfusedFlow",
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+ "(plasma,venous):brainBlood":"brainBloodFlow",
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+ "(plasma,venous):placenta":"placentaFlow",
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+ "plasma:liver":"liverInFlow",
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+ "liver:venous":"liverOutFlow",
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+ "(plasma,liver):gut":"gutFlow",
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+ "plasma:venous":"plasmaFlow"},
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+ "commentSources":"constants in concentration units per s",
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+ "commentHeavyside":"value is mass of exogene/volume of container/duration",
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+ "sources":{
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+ "arterial":{"name":"exponential","k":-0.005,"constant":0},
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+ "venous":{"name":"Heavyside","limit":3,"value":1.22e4}},
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+ "commentBindings":"split to flow and diffusion dominated",
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+ "bindings": {
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+ "flowComments":"group common sources or targets with brackets",
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+ "flow":[
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+ "(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver)->venous",
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+ "gut->liver",
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+ "plasma->(kidney,richlyPerfused,fat,slowlyPerfused,brainBlood,placenta,liver,gut)",
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+ "venous->plasma"],
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+ "diffusion":{
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+ "plasma->redBloodCells":"kRBC",
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+ "kidney->urine":"kU",
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+ "slowlyPerfused->hair":"kH",
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+ "brainBlood->brain":"kBR",
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+ "liver->intestine":"kB",
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+ "liver->inorganicMercury":"kI",
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+ "intestine->gut":"kR",
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+ "intestine->inorganicMercury":"kD",
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+ "intestine->feces":"kF",
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+ "inorganicMercury->feces":"kF1"}},
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+ "pcComments":"always related to outflow of organs",
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+ "partitionCoefficients":{
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+ "kidney":"kidneyPC",
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+ "richlyPerfused":"richlyPerfusedPC",
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+ "fat":"fatPC",
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+ "slowlyPerfused":"slowlyPerfusedPC",
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+ "brainBlood":"brainBloodPC",
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+ "placenta":"placentaPC",
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+ "liver":"liverPC",
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+ "gut":"gutPC",
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+ "brainBlood->brain":"brainPC",
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+ "slowlyPerfused->hair":"hairPC",
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+ "plasma->redBloodCells":"rbcPC"},
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+ "parameters":{
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+ "kidneyPC":{"value":4.0},
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+ "richlyPerfusedPC":{"value":1},
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+ "fatPC":{"value":0.15},
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+ "slowlyPerfusedPC":{"value":2},
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+ "brainBloodPC":{"value":1},
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+ "brainPC":{"value":3},
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+ "hairPC":{"value":248.7},
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+ "placentaPC":{"value":2},
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+ "liverPC":{"value":5},
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+ "gutPC":{"value":1},
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+ "rbcPC":{"value":12},
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+ "flowNotes":"assuming 70kg individual, fetus at 0.1kg",
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+ "kidneyFlow":{"value":1.412,"unit":"l/min"},
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+ "richlyPerfusedFlow":{"value":1.484,"unit":"l/min"},
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+ "fatFlow":{"value":0.419,"unit":"l/min"},
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+ "slowlyPerfusedFlow":{"value":2.01,"unit":"l/min"},
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+ "brainBloodFlow":{"value":0.920,"unit":"l/min"},
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+ "placentaFlow":{"value":0.173,"unit":"l/min"},
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+ "liverInFlow":{"value":0.391,"unit":"l/min"},
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+ "liverOutFlow":{"value":1.928,"unit":"l/min"},
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+ "gutFlow":{"value":1.538,"unit":"l/min"},
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+ "plasmaVolume":{"value":1.64,"unit":"kg"},
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+ "redBloodCellsVolume":{"value":1.64,"unit":"kg"},
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+ "kidneyVolume":{"value":0.28,"unit":"kg"},
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+ "richlyPerfusedVolume":{"value":7,"unit":"kg"},
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+ "fatVolume":{"value":19.11,"unit":"kg"},
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+ "hairVolume":{"value":0.14,"unit":"kg"},
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+ "slowlyPerfusedVolume":{"value":24.5,"unit":"kg"},
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+ "brainBloodVolume":{"value":0.49,"unit":"kg"},
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+ "brainVolume":{"value":1.4,"unit":"kg"},
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+ "placentaVolume":{"value":0.0431,"unit":"kg"},
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+ "liverVolume":{"value":1.82,"unit":"kg"},
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+ "gutVolume":{"value":1.19,"unit":"kg"},
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+ "intestineVolume":{"value":0.98,"unit":"kg"},
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+ "kRBC":{"value":0.025,"unit":"l/min"},
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+ "kU":{"value":0,"unit":"l/min"},
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+ "kH":{"value":1.167e-7,"unit":"l/min"},
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+ "kBR":{"value":1.67e-4,"unit":"l/min"},
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+ "kI":{"value":1.67e-7,"unit":"l/min"},
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+ "kB":{"value":1.67e-6,"unit":"l/min"},
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+ "kD":{"value":1.67e-6,"unit":"l/min"},
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+ "kF":{"value":3.33e-6,"unit":"l/min"},
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+ "kF1":{"value":0,"unit":"l/min"},
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+ "kR":{"value":8.33e-5,"unit":"l/min"}
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+}
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