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@@ -2,75 +2,107 @@
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"compartments":["adipose","brain","heart","kidney","liver",
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"splanchnic","stomach","muscle","skin","testes","remainder","lung",
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"excrement","arterial","venous","source"],
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+ "commentParameters":"every parameter must have a value, name is optional and used in SE computation",
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"volumes":{
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- "unit":"g",
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- "adipose":10,
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- "brain":1.2,
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- "heart":1,
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- "kidney":2,
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- "liver":11,
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- "lung":1.2,
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- "muscle":125,
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- "skin":43.8,
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- "splanchnic":15,
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- "stomach":1.1,
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- "testes":2.5,
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- "remainder":15.8,
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- "venous":13.6,
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- "arterial":6.8},
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- "flowNotes":"liver:arterial is sum of liver,splanchnic and stomach",
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- "flowNotes1":"liver:arterial=3.55+20.25+1.9",
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+ "adipose":"adiposeVolume",
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+ "brain":"brainVolume",
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+ "heart":"heartVolume",
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+ "kidney":"kidneyVolume",
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+ "liver":"liverVolume",
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+ "lung":"lungVolume",
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+ "muscle":"muscleVolume",
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+ "skin":"skinVolume",
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+ "splanchnic":"splanchnicVolume",
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+ "stomach":"stomachVolume",
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+ "testes":"testesVolume",
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+ "remainder":"remainderVolume",
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+ "venous":"venousVolume",
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+ "arterial":"arterialVolume"},
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"flows":{
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- "unit":"ml/min",
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- "(arterial,venous):adipose":2.55,
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- "(arterial,venous):brain":0.78,
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- "(arterial,venous):heart":4.2,
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- "(arterial,venous):kidney":16.61,
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- "arterial:liver":3.55,
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- "liver:venous":25.7,
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- "(arterial,venous):lung":80,
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- "(arterial,venous):muscle":16.25,
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- "(arterial,venous):skin":7.1,
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- "(arterial,liver):splanchnic":20.25,
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- "(arterial,liver):stomach":1.9,
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- "(arterial,venous):testes":1.9,
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- "(arterial,venous):remainder":4.91,
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- "arterial":80,
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- "venous":80},
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+ "(arterial,venous):adipose":"adiposeFlow",
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+ "(arterial,venous):brain":"brainFlow",
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+ "(arterial,venous):heart":"heartFlow",
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+ "(arterial,venous):kidney":"kidneyFlow",
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+ "arterial:liver":"liverInFlow",
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+ "liver:venous":"liverOutFlow",
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+ "(arterial,venous):lung":"totalFlow",
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+ "(arterial,venous):muscle":"muscleFlow",
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+ "(arterial,venous):skin":"skinFlow",
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+ "(arterial,liver):splanchnic":"splanchnicFlow",
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+ "(arterial,liver):stomach":"stomachFlow",
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+ "(arterial,venous):testes":"testesFlow",
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+ "(arterial,venous):remainder":"remainderFlow"},
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"commentSources":"constants in concentration units per s",
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"sources":{
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"arterial":{"name":"exponential","k":-0.005,"constant":0},
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"venous":{"name":"Heavyside","limit":30,"value":1.22e3}},
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"commentBindings":"split to flow and diffusion dominated",
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"bindings": {
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- "flowComments":"group common sources or targets with braces",
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+ "flowComments":"group common sources or targets with brackets",
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"flow":[
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"(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder)->venous",
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"(splanchnic,stomach)->liver",
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"arterial->(adipose,brain,heart,kidney,liver,muscle,skin,testes,remainder,splanchnic,stomach)",
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"venous->lung",
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"lung->arterial"],
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- "diffusionComments":"source->target strength per s",
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- "liverToExcrementNotes":"CL=422ml/min,PC=9.1,f=0.15,V=11g->k=0.105/s",
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- "sourceToArterialNotes":"ka=0.001/s in paper",
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- "comment:source->venous":0.005,
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"diffusion":{
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- "liver->excrement":0.0105}},
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+ "liver->excrement":"k1"}},
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"pcComments":"always related to outflow of organs",
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"partitionCoefficients":{
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- "adipose":0.04,
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- "brain":0.27,
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- "heart":0.28,
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- "kidney":0.72,
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- "liver":0.39,
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- "lung":0.3,
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- "muscle":0.29,
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- "remainder":0.18,
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- "skin":0.18,
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- "splanchnic":0.31,
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- "stomach":0.18,
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- "testes":0.18},
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- "sensitivityCalculation":{
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- "parameters":["partitionCoefficients"]
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- }
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+ "adipose":"adiposePC",
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+ "brain":"brainPC",
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+ "heart":"heartPC",
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+ "kidney":"kidneyPC",
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+ "liver":"liverPC",
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+ "lung":"lungPC",
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+ "muscle":"musclePC",
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+ "remainder":"remainderPC",
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+ "skin":"remainderPC",
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+ "splanchnic":"splanchnicPC",
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+ "stomach":"stomachPC",
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+ "testes":"testesPC"},
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+ "parameters":{
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+ "adiposePC":{"value":0.06,"range":[0.05,0.07]},
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+ "brainPC":{"value":0.27},
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+ "heartPC":{"value":0.28},
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+ "kidneyPC":{"value":0.72},
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+ "liverPC":{"value":0.39},
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+ "lungPC":{"value":0.3},
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+ "musclePC":{"value":0.29},
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+ "remainderPC":{"value":0.18},
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+ "splanchnicPC":{"value":0.31},
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+ "stomachPC":{"value":0.18},
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+ "testesPC":{"value":0.18},
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+ "flowNotes":"liverOutFlow is sum of liver,splanchnic and stomach",
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+ "flowNotes1":"liverOutFlow=3.55+20.25+1.9",
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+ "adiposeFlow":{"value":2.55,"unit":"ml/min"},
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+ "brainFlow":{"value":0.78,"unit":"ml/min"},
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+ "heartFlow":{"value":4.2,"unit":"ml/min"},
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+ "kidneyFlow":{"value":16.61,"unit":"ml/min"},
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+ "liverInFlow":{"value":3.55,"unit":"ml/min"},
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+ "liverOutFlow":{"value":25.7,"unit":"ml/min"},
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+ "totalFlow":{"value":80,"unit":"ml/min"},
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+ "muscleFlow":{"value":16.25,"unit":"ml/min"},
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+ "skinFlow":{"value":7.1,"unit":"ml/min"},
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+ "splanchnicFlow":{"value":20.25,"unit":"ml/min"},
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+ "stomachFlow":{"value":1.9,"unit":"ml/min"},
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+ "testesFlow":{"value":1.9,"unit":"ml/min"},
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+ "remainderFlow":{"value":4.91,"unit":"ml/min"},
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+ "adiposeVolume":{"value":10,"unit":"g"},
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+ "brainVolume":{"value":1.2,"unit":"g"},
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+ "heartVolume":{"value":1,"unit":"g"},
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+ "kidneyVolume":{"value":2,"unit":"g"},
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+ "liverVolume":{"value":11,"unit":"g"},
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+ "lungVolume":{"value":1.2,"unit":"g"},
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+ "muscleVolume":{"value":125,"unit":"g"},
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+ "skinVolume":{"value":43.8,"unit":"g"},
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+ "splanchnicVolume":{"value":15,"unit":"g"},
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+ "stomachVolume":{"value":1.1,"unit":"g"},
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+ "testesVolume":{"value":2.5,"unit":"g"},
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+ "remainderVolume":{"value":15.8,"unit":"g"},
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+ "venousVolume":{"value":13.6,"unit":"g"},
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+ "arterialVolume":{"value":6.8,"unit":"g"},
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+ "liverToExcrementNotes":"CL=0.13 ml/min,PC=0.39,f=0.97,V=11g->k1=0.00049/s",
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+ "k1":{"value":0.0105,"unit":"1/s"}}
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+
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}
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